Gene/Proteome Database (LMPD)
LMPD ID
LMP010463
Gene ID
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
histone-lysine N-methyltransferase ATX1
Gene Symbol
Synonyms
homologue of trithorax; SDG27; SET DOMAIN PROTEIN 27; T9H9.17; T9H9_17
Alternate Names
histone-lysine N-methyltransferase ATX1
Chromosome
2
EC Number
2.1.1.43
Summary
Encodes a homolog of trithorax, a histone-lysine N-methyltransferase. Involved in trimethylating histone H3-lysine 4. Involved in the formation, placement, and identity of flower organs. Role in regulation of homeotic genes. Functions as a receptor of phosphatidylinositol 5-phosphate. Localizes to cytoplasm, plasma membrane and nuclei, shifting to nuclei in the presence of PI5P.
Orthologs
Proteins
| histone-lysine N-methyltransferase ATX1 | |
|---|---|
| Refseq ID | NP_850170 |
| Protein GI | 30685011 |
| UniProt ID | Q9C5X4 |
| mRNA ID | NM_179839 |
| Length | 1062 |
| RefSeq Status | REVIEWED |
| MACFSNETQIEIDVHDLVEAPIRYDSIESIYSIPSSALCCVNAVGSHSLMSKKVKAQKLPMIEQFEIEGSGVSASDDCCRSDDYKLRIQRPEIVRVYYRRRKRPLRECLLDQAVAVKTESVELDEIDCFEEKKRRKIGNCELVKSGMESIGLRRCKENNAFSGNKQNGSSRRKGSSSKNQDKATLASRSAKKWVRLSYDGVDPTSFIGLQCKVFWPLDALWYEGSIVGYSAERKRYTVKYRDGCDEDIVFDREMIKFLVSREEMELLHLKFCTSNVTVDGRDYDEMVVLAATLDECQDFEPGDIVWAKLAGHAMWPAVIVDESIIGERKGLNNKVSGGGSLLVQFFGTHDFARIKVKQAISFIKGLLSPSHLKCKQPRFEEGMQEAKMYLKAHRLPERMSQLQKGADSVDSDMANSTEEGNSGGDLLNDGEVWLRPTEHVDFRHIIGDLLIINLGKVVTDSQFFKDENHIWPEGYTAMRKFTSLTDHSASALYKMEVLRDAETKTHPLFIVTADSGEQFKGPTPSACWNKIYNRIKKVQNSDSPNILGEELNGSGTDMFGLSNPEVIKLVQDLSKSRPSSHVSMCKNSLGRHQNQPTGYRPVRVDWKDLDKCNVCHMDEEYENNLFLQCDKCRMMVHAKCYGELEPCDGALWLCNLCRPGAPDMPPRCCLCPVVGGAMKPTTDGRWAHLACAIWIPETCLSDVKKMEPIDGVNKVSKDRWKLMCTICGVSYGACIQCSNNSCRVAYHPLCARAAGLCVELENDMSVEGEEADQCIRMLSFCKRHRQTSTACLGSEDRIKSATHKTSEYLPPPNPSGCARTEPYNCFGRRGRKEPEALAAASSKRLFVENQPYVIGGYSRLEFSTYKSIHGSKVSQMNTPSNILSMAEKYRYMRETYRKRLAFGKSGIHGFGIFAKLPHRAGDMMIEYTGELVRPSIADKREQLIYNSMVGAGTYMFRIDDERVIDATRTGSIAHLINHSCVPNCYSRVITVNGDEHIIIFAKRHIPKWEELTYDYRFFSIGERLSCSCGFPGCRGVVNDTEAEEQHAKICVPRCDLIDWTAE | |
Gene Information
Entrez Gene ID
Gene Name
histone-lysine N-methyltransferase ATX1
Gene Symbol
Species
Arabidopsis thaliana
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | IDA:TAIR | C | cytoplasm |
| GO:0005634 | IDA:TAIR | C | nucleus |
| GO:0005886 | IDA:TAIR | C | plasma membrane |
| GO:0018024 | IDA:TAIR | F | histone-lysine N-methyltransferase activity |
| GO:0010314 | IDA:TAIR | F | phosphatidylinositol-5-phosphate binding |
| GO:0044212 | IDA:TAIR | F | transcription regulatory region DNA binding |
| GO:0008270 | IEA:InterPro | F | zinc ion binding |
| GO:0051568 | IDA:TAIR | P | histone H3-K4 methylation |
| GO:0035556 | IEA:InterPro | P | intracellular signal transduction |
| GO:0009909 | IMP:TAIR | P | regulation of flower development |
| GO:0006355 | IMP:TAIR | P | regulation of transcription, DNA-templated |
| GO:0010093 | IMP:TAIR | P | specification of floral organ identity |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR003889 | FY-rich, C-terminal |
| IPR003888 | FY-rich, N-terminal |
| IPR019023 | Lamin-B receptor of TUDOR domain |
| IPR000313 | PWWP domain |
| IPR003616 | Post-SET domain |
| IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| IPR001214 | SET domain |
| IPR011011 | Zinc finger, FYVE/PHD-type |
| IPR019787 | Zinc finger, PHD-finger |
| IPR001965 | Zinc finger, PHD-type |
| IPR019786 | Zinc finger, PHD-type, conserved site |
| IPR013083 | Zinc finger, RING/FYVE/PHD-type |
UniProt Annotations
Entry Information
Gene Name
histone-lysine N-methyltransferase ATX1
Protein Entry
ATX1_ARATH
UniProt ID
Species
Arabidopsis
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9C5X4-1; Sequence=Displayed; Name=2; IsoId=Q9C5X4-2; Sequence=VSP_018132; Note=No experimental confirmation available.; |
| Catalytic Activity | S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. |
| Developmental Stage | Expression is associated with the initiation of flower organs and ovules. {ECO:0000269|PubMed:12699618}. |
| Function | Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Required to maintain the active state of class A (AP1 and AP2), class B (PI and AP3) and class C (AG) floral homeotic genes at early stages of flower development. Regulates floral organ identity and flowering transition. Functions as a receptor for the lipid messenger phosphatidylinositol 5-phosphate (PI5P), which regulates negatively its transcriptional activation activity. {ECO:0000269|PubMed:12699618, ECO:0000269|PubMed:16585509}. |
| Sequence Caution | Sequence=AAD24842.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; |
| Similarity | Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. {ECO:0000255|PROSITE-ProRule:PRU00190}. |
| Similarity | Contains 1 FYR C-terminal domain. {ECO:0000255|PROSITE-ProRule:PRU00876}. |
| Similarity | Contains 1 FYR N-terminal domain. {ECO:0000255|PROSITE-ProRule:PRU00875}. |
| Similarity | Contains 1 PHD-type zinc finger. {ECO:0000255|PROSITE- ProRule:PRU00146}. |
| Similarity | Contains 1 PWWP domain. {ECO:0000255|PROSITE- ProRule:PRU00162}. |
| Similarity | Contains 1 SET domain. {ECO:0000255|PROSITE- ProRule:PRU00190}. |
| Similarity | Contains 1 phorbol-ester/DAG-type zinc finger. {ECO:0000255|PROSITE-ProRule:PRU00226}. |
| Similarity | Contains 1 post-SET domain. {ECO:0000255|PROSITE- ProRule:PRU00155}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:16585509}. Cytoplasm {ECO:0000269|PubMed:16585509}. Note=Shifts from nucleus to cytoplasm as PIP5 levels increase. When in the nucleus, associated with chromatin. When cytoplasmic, mostly localized along the plasma membrane, associated with PIP5. |
| Subunit | Interacts with PIP5. {ECO:0000269|PubMed:16585509}. |
| Tissue Specificity | Ubiquitous with higher levels in dividing tissues, including inflorescence meristem and flower primordia. {ECO:0000269|PubMed:11418242, ECO:0000269|PubMed:12699618}. |
| Web Resource | Name=PlantsUBQ; Note=A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants; URL="http://plantsubq.genomics.purdue.edu/"; |
Identical and Related Proteins
Unique RefSeq proteins for LMP010463 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 30685011 | RefSeq | NP_850170 | 1062 | histone-lysine N-methyltransferase ATX1 |
Identical Sequences to LMP010463 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:30685011 | GenBank | AEC08569.1 | 1062 | histone-lysine N-methyltransferase ATX1 [Arabidopsis thaliana] |
| GI:30685011 | SwissProt | Q9C5X4.2 | 1062 | RecName: Full=Histone-lysine N-methyltransferase ATX1; AltName: Full=Protein SET DOMAIN GROUP 27; AltName: Full=Trithorax-homolog protein 1; Short=TRX-homolog protein 1 [Arabidopsis thaliana] |
Related Sequences to LMP010463 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:30685011 | GenBank | AAK01237.1 | 1062 | trithorax-like protein 1 [Arabidopsis thaliana] |
| GI:30685011 | GenBank | EFH57445.1 | 1066 | hypothetical protein ARALYDRAFT_902198 [Arabidopsis lyrata subsp. lyrata] |
| GI:30685011 | GenBank | EOA26497.1 | 1064 | hypothetical protein CARUB_v10022547mg [Capsella rubella] |
| GI:30685011 | RefSeq | XP_002881186.1 | 1066 | hypothetical protein ARALYDRAFT_902198 [Arabidopsis lyrata subsp. lyrata] |
| GI:30685011 | RefSeq | XP_006293599.1 | 1064 | hypothetical protein CARUB_v10022547mg [Capsella rubella] |
| GI:30685011 | RefSeq | XP_010414104.1 | 1054 | PREDICTED: histone-lysine N-methyltransferase ATX1 isoform X1 [Camelina sativa] |