Gene/Proteome Database (LMPD)
LMPD ID
LMP010467
Gene ID
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
homeobox-leucine zipper protein ATHB-14
Gene Symbol
Synonyms
ARABIDOPSIS THALIANA HOMEOBOX PROTEIN 14; ATHB-14; ATHB14; PHABULOSA; PHABULOSA 1D; PHB; PHB-1D; T29F13.8; T29F13_8
Alternate Names
homeobox-leucine zipper protein ATHB-14
Chromosome
2
Summary
Dominant PHB mutations cause transformation of abaxial leaf fates into adaxial leaf fates. Encodes a member of HD-Zip family which contains homeodomain-leucine zipper domains and domain similar to a mammalian sterol binding domain. Has overlapping functions with PHAVOLUTA, REVOLUTA and CORONA.
Orthologs
Proteins
| homeobox-leucine zipper protein ATHB-14 | |
|---|---|
| Refseq ID | NP_181018 |
| Protein GI | 15226808 |
| UniProt ID | O04291 |
| mRNA ID | NM_129025 |
| Length | 852 |
| RefSeq Status | REVIEWED |
| MMMVHSMSRDMMNRESPDKGLDSGKYVRYTPEQVEALERVYTECPKPSSLRRQQLIRECPILSNIEPKQIKVWFQNRRCREKQRKEAARLQTVNRKLNAMNKLLMEENDRLQKQVSNLVYENGHMKHQLHTASGTTTDNSCESVVVSGQQHQQQNPNPQHQQRDANNPAGLLSIAEEALAEFLSKATGTAVDWVQMIGMKPGPDSIGIVAISRNCSGIAARACGLVSLEPMKVAEILKDRPSWLRDCRSVDTLSVIPAGNGGTIELIYTQMYAPTTLAAARDFWTLRYSTCLEDGSYVVCERSLTSATGGPTGPPSSNFVRAEMKPSGFLIRPCDGGGSILHIVDHVDLDAWSVPEVMRPLYESSKILAQKMTVAALRHVRQIAQETSGEVQYGGGRQPAVLRTFSQRLCRGFNDAVNGFVDDGWSPMGSDGAEDVTVMINLSPGKFGGSQYGNSFLPSFGSGVLCAKASMLLQNVPPAVLVRFLREHRSEWADYGVDAYAAASLRASPFAVPCARAGGFPSNQVILPLAQTVEHEESLEVVRLEGHAYSPEDMGLARDMYLLQLCSGVDENVVGGCAQLVFAPIDESFADDAPLLPSGFRIIPLEQKSTPNGASANRTLDLASALEGSTRQAGEADPNGCNFRSVLTIAFQFTFDNHSRDSVASMARQYVRSIVGSIQRVALAIAPRPGSNISPISVPTSPEALTLVRWISRSYSLHTGADLFGSDSQTSGDTLLHQLWNHSDAILCCSLKTNASPVFTFANQTGLDMLETTLVALQDIMLDKTLDEPGRKALCSEFPKIMQQGYAHLPAGVCASSMGRMVSYEQATVWKVLEDDESNHCLAFMFVNWSFV | |
Gene Information
Entrez Gene ID
Gene Name
homeobox-leucine zipper protein ATHB-14
Gene Symbol
Species
Arabidopsis thaliana
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005634 | IDA:TAIR | C | nucleus |
| GO:0003677 | ISS:TAIR | F | DNA binding |
| GO:0008289 | IEA:InterPro | F | lipid binding |
| GO:0003700 | ISS:TAIR | F | sequence-specific DNA binding transcription factor activity |
| GO:0009955 | IMP:TAIR | P | adaxial/abaxial pattern specification |
| GO:0030154 | IEA:UniProtKB-KW | P | cell differentiation |
| GO:0009855 | IMP:TAIR | P | determination of bilateral symmetry |
| GO:0080060 | IGI:TAIR | P | integument development |
| GO:0010014 | IMP:TAIR | P | meristem initiation |
| GO:0009944 | IMP:TAIR | P | polarity specification of adaxial/abaxial axis |
| GO:0010072 | IMP:TAIR | P | primary shoot apical meristem specification |
| GO:0006351 | IEA:UniProtKB-KW | P | transcription, DNA-templated |
Domain Information
UniProt Annotations
Entry Information
Gene Name
homeobox-leucine zipper protein ATHB-14
Protein Entry
ATB14_ARATH
UniProt ID
Species
Arabidopsis
Comments
| Comment Type | Description |
|---|---|
| Developmental Stage | Expressed at the youngest stages of ovule development, predominantly to the adaxial side of the ovule primordium. Later, expression becomes restricted to a region in the distal chalaza. When the integuments initiate, expressed in the inner integument, with highest expression in the inner layer of the inner integument. Expressed in the vegetative shoot apical meristem (SAM) and initially throughout the presumptive cotyledons. At the globular stage, just before cotyledon outgrowth, expressed at high levels in cotyledon adaxial domains. Expression is lost from the SAM of torpedo stage embryos but is regained late in embryogenesis, extending to young primordia after germination, and becoming progressively restricted to the adaxial domain and the vasculature. Preferentially expressed in the adaxial domain of the developing leaf. Expressed throughout the plastochron 0 (P0) leaf primordium and expression increases in P1 to become preferentially localized to the adaxial leaf domain by the P2 stage (polar expression). {ECO:0000269|PubMed:11395776, ECO:0000269|PubMed:15328016}. |
| Function | Probable transcription factor involved in the determination of adaxial-abaxial polarity in ovule primordium. Specifies adaxial leaf fates. {ECO:0000269|PubMed:11395776, ECO:0000269|PubMed:15328016, ECO:0000269|PubMed:15598805}. |
| Induction | Repressed by miR165 and miR166. {ECO:0000269|PubMed:14999284, ECO:0000269|PubMed:16033795, ECO:0000269|PubMed:17237362}. |
| Similarity | Belongs to the HD-ZIP homeobox family. Class III subfamily. {ECO:0000305}. |
| Similarity | Contains 1 homeobox DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00108}. |
| Similarity | Contains 1 START domain. {ECO:0000255|PROSITE- ProRule:PRU00197}. |
| Subcellular Location | Nucleus {ECO:0000305}. |
| Subunit | Interacts with ESR1 and ESR2. {ECO:0000269|PubMed:17376809}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP010467 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 15226808 | RefSeq | NP_181018 | 852 | homeobox-leucine zipper protein ATHB-14 |
Identical Sequences to LMP010467 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:15226808 | GenBank | AEQ40129.1 | 852 | Sequence 336 from patent US 8030546 |
| GI:15226808 | GenBank | AFC08073.1 | 852 | Sequence 72 from patent US 8110725 |
| GI:15226808 | GenBank | AGA37117.1 | 852 | Sequence 6 from patent US 8314291 |
| GI:15226808 | GenBank | AGM80059.1 | 852 | Sequence 72 from patent US 8426678 |
| GI:15226808 | GenBank | AGM82861.1 | 852 | Sequence 28 from patent US 8426685 |
| GI:15226808 | GenBank | AGX49569.1 | 852 | Sequence 1392 from patent US 8541665 |
Related Sequences to LMP010467 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:15226808 | GenBank | EOA26257.1 | 846 | hypothetical protein CARUB_v10022629mg [Capsella rubella] |
| GI:15226808 | RefSeq | XP_006293359.1 | 846 | hypothetical protein CARUB_v10022629mg [Capsella rubella] |
| GI:15226808 | RefSeq | XP_006410621.1 | 846 | hypothetical protein EUTSA_v10016241mg [Eutrema salsugineum] |
| GI:15226808 | RefSeq | XP_010504942.1 | 847 | PREDICTED: homeobox-leucine zipper protein ATHB-14-like [Camelina sativa] |
| GI:15226808 | RefSeq | XP_010509720.1 | 847 | PREDICTED: homeobox-leucine zipper protein ATHB-14 [Camelina sativa] |
| GI:15226808 | RefSeq | XP_010516626.1 | 849 | PREDICTED: homeobox-leucine zipper protein ATHB-14-like [Camelina sativa] |