Gene/Proteome Database (LMPD)

LMPD ID
LMP010471
Gene ID
839928
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
homeobox-leucine zipper protein ATHB-9
Gene Symbol
PHV
Synonyms
ATHB9; F26G16.11; F26G16_11; PHAVOLUTA; PHV
Alternate Names
homeobox-leucine zipper protein ATHB-9
Chromosome
1
Summary
Dominant PHV mutations cause transformation of abaxial leaf fates into adaxial leaf fates. Has overlapping functions with PHABULOSA, REVOLUTA and CORONA/ATHB15 in patterning the apical portion of the embryo. Encodes a member of HD-Zip family which contains homeodomain-leucine zipper domains and domain similar to a mammalian sterol binding domain.
Orthologs
View orthologs and multiple alignments for PHV

Proteins

homeobox-leucine zipper protein ATHB-9
Refseq ID NP_174337
Protein GI 15220758
UniProt ID O04292
mRNA ID NM_102785
Length 841
RefSeq Status REVIEWED
MMAHHSMDDRDSPDKGFDSGKYVRYTPEQVEALERVYAECPKPSSLRRQQLIRECPILCNIEPRQIKVWFQNRRCREKQRKESARLQTVNRKLSAMNKLLMEENDRLQKQVSNLVYENGFMKHRIHTASGTTTDNSCESVVVSGQQRQQQNPTHQHPQRDVNNPANLLSIAEETLAEFLCKATGTAVDWVQMIGMKPGPDSIGIVAVSRNCSGIAARACGLVSLEPMKVAEILKDRPSWFRDCRCVETLNVIPTGNGGTIELVNTQIYAPTTLAAARDFWTLRYSTSLEDGSYVVCERSLTSATGGPNGPLSSSFVRAKMLSSGFLIRPCDGGGSIIHIVDHVDLDVSSVPEVLRPLYESSKILAQKMTVAALRHVRQIAQETSGEVQYSGGRQPAVLRTFSQRLCRGFNDAVNGFVDDGWSPMSSDGGEDITIMINSSSAKFAGSQYGSSFLPSFGSGVLCAKASMLLQNVPPLVLIRFLREHRAEWADYGVDAYSAASLRATPYAVPCVRTGGFPSNQVILPLAQTLEHEEFLEVVRLGGHAYSPEDMGLSRDMYLLQLCSGVDENVVGGCAQLVFAPIDESFADDAPLLPSGFRVIPLDQKTNPNDHQSASRTRDLASSLDGSTKTDSETNSRLVLTIAFQFTFDNHSRDNVATMARQYVRNVVGSIQRVALAITPRPGSMQLPTSPEALTLVRWITRSYSIHTGADLFGADSQSCGGDTLLKQLWDHSDAILCCSLKTNASPVFTFANQAGLDMLETTLVALQDIMLDKTLDDSGRRALCSEFAKIMQQGYANLPAGICVSSMGRPVSYEQATVWKVVDDNESNHCLAFTLVSWSFV

Gene Information

Entrez Gene ID
839928
Gene Name
homeobox-leucine zipper protein ATHB-9
Gene Symbol
PHV
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0003677 ISS:TAIR F DNA binding
GO:0008289 IEA:InterPro F lipid binding
GO:0003700 ISS:TAIR F sequence-specific DNA binding transcription factor activity
GO:0009943 IMP:TAIR P adaxial/abaxial axis specification
GO:0030154 IEA:UniProtKB-KW P cell differentiation
GO:0009855 IMP:TAIR P determination of bilateral symmetry
GO:0009880 IGI:TAIR P embryonic pattern specification
GO:0080060 IGI:TAIR P integument development
GO:0010014 IMP:TAIR P meristem initiation
GO:0009944 IMP:TAIR P polarity specification of adaxial/abaxial axis
GO:0010072 IMP:TAIR P primary shoot apical meristem specification
GO:0006351 IEA:UniProtKB-KW P transcription, DNA-templated

Domain Information

InterPro Annotations

Accession Description
IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR013978 MEKHLA
IPR023393 START-like domain
IPR002913 START_lipid-bd_dom

UniProt Annotations

Entry Information

Gene Name
homeobox-leucine zipper protein ATHB-9
Protein Entry
ATBH9_ARATH
UniProt ID
O04292
Species
Arabidopsis

Comments

Comment Type Description
Function Probable transcription factor involved in the determination of adaxial-abaxial polarity in ovule primordium. Specifies adaxial leaf fates. Binds to the DNA sequence 5'- GTAAT[GC]ATTAC-3'. {ECO:0000269|PubMed:11395776, ECO:0000269|PubMed:15598805, ECO:0000269|PubMed:17900520, ECO:0000269|PubMed:9747806}.
Induction By auxin. Repressed by miR165 and miR166. {ECO:0000269|PubMed:14999284, ECO:0000269|PubMed:16033795, ECO:0000269|PubMed:17237362}.
Interaction Q9LEZ3:BIM1; NbExp=2; IntAct=EBI-1536772, EBI-617095; Q9SAD4:ESR1; NbExp=5; IntAct=EBI-1536772, EBI-1536756; Q9FYK5:ESR2; NbExp=2; IntAct=EBI-1536772, EBI-1536925;
Sequence Caution Sequence=AAF19752.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the HD-ZIP homeobox family. Class III subfamily. {ECO:0000305}.
Similarity Contains 1 homeobox DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00108}.
Similarity Contains 1 START domain. {ECO:0000255|PROSITE- ProRule:PRU00197}.
Subcellular Location Nucleus {ECO:0000305}.
Subunit Binds DNA as homodimer. Interacts with ESR1 and ESR2. {ECO:0000269|PubMed:17376809, ECO:0000269|PubMed:9747806}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010471 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15220758 RefSeq NP_174337 841 homeobox-leucine zipper protein ATHB-9

Identical Sequences to LMP010471 proteins

Reference Database Accession Length Protein Name
GI:15220758 GenBank AEI23652.1 841 Sequence 2236 from patent US 7960612
GI:15220758 GenBank AEQ40128.1 841 Sequence 334 from patent US 8030546
GI:15220758 GenBank AFC08072.1 841 Sequence 70 from patent US 8110725
GI:15220758 GenBank AGM80058.1 841 Sequence 70 from patent US 8426678
GI:15220758 GenBank AGM82860.1 841 Sequence 26 from patent US 8426685
GI:15220758 GenBank AGX49568.1 841 Sequence 1390 from patent US 8541665

Related Sequences to LMP010471 proteins

Reference Database Accession Length Protein Name
GI:15220758 GenBank AAF19752.1 840 Strong similarity to gb|Y10922 HD-Zip protein from Arabidopsis thaliana, containing START PF|01852, bZIP transcription factor PF|00170, and homeobox PF|00046 domains. ESTs gb|F20019, gb|Z46707, gb|Z46706, gb|F20018 come from this gene [Arabidopsis thaliana]
GI:15220758 GenBank EFH69886.1 840 hypothetical protein ARALYDRAFT_473277 [Arabidopsis lyrata subsp. lyrata]
GI:15220758 GenBank EOA39662.1 840 hypothetical protein CARUB_v10008304mg [Capsella rubella]
GI:15220758 RefSeq XP_002893627.1 840 hypothetical protein ARALYDRAFT_473277 [Arabidopsis lyrata subsp. lyrata]
GI:15220758 RefSeq XP_006306764.1 840 hypothetical protein CARUB_v10008304mg [Capsella rubella]
GI:15220758 RefSeq XP_010460847.1 840 PREDICTED: homeobox-leucine zipper protein ATHB-9 [Camelina sativa]