Gene/Proteome Database (LMPD)

LMPD ID
LMP010485
Gene ID
828263
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
homeobox-leucine zipper protein MERISTEM L1
Gene Symbol
ATML1
Synonyms
F17L22.210; F17L22_210; MERISTEM LAYER 1
Alternate Names
homeobox-leucine zipper protein MERISTEM L1
Chromosome
4
Summary
Encodes a homeobox protein similar to GL2. It is expressed in both the apical and basal daughter cells of the zygote as well as their progeny. Expression is detected starting the two-celled stage of embryo development and is later restricted to the outermost, epidermal cell layer from its inception. Its promoter is highly modular with each region contributing to specific aspects of the gene's spatial and temporal expression. Double mutant analysis with PDF2, another L1-specific gene, suggests that their functions are partially redundant and the absence of both of the genes result in abnormal shoot development.
Orthologs
View orthologs and multiple alignments for ATML1

Proteins

homeobox-leucine zipper protein MERISTEM L1
Refseq ID NP_001031692
Protein GI 79325215
UniProt ID Q8RWU4
mRNA ID NM_001036615
Length 762
RefSeq Status REVIEWED
MYHPNMFESHHHMFDMTPKNSENDLGITGSHEEDFETKSGAEVTMENPLEEELQDPNQRPNKKKRYHRHTQRQIQELESFFKECPHPDDKQRKELSRELSLEPLQVKFWFQNKRTQMKAQHERHENQILKSENDKLRAENNRYKDALSNATCPNCGGPAAIGEMSFDEQHLRIENARLREEIDRISAIAAKYVGKPLMANSSSFPQLSSSHHIPSRSLDLEVGNFGNNNNSHTGFVGEMFGSSDILRSVSIPSEADKPMIVELAVAAMEELVRMAQTGDPLWVSSDNSVEILNEEEYFRTFPRGIGPKPIGLRSEASRESTVVIMNHINLIEILMDVNQWSSVFCGIVSRALTLEVLSTGVAGNYNGALQVMTAEFQVPSPLVPTRENYFVRYCKQHSDGIWAVVDVSLDSLRPSPITRSRRRPSGCLIQELQNGYSKVTWVEHIEVDDRSVHNMYKPLVNTGLAFGAKRWVATLDRQCERLASSMASNIPACDLSVITSPEGRKSMLKLAERMVMSFCTGVGASTAHAWTTLSTTGSDDVRVMTRKSMDDPGRPPGIVLSAATSFWIPVAPKRVFDFLRDENSRSEWDILSNGGLVQEMAHIANGRDPGNSVSLLRVNSGNSGQSNMLILQESCTDASGSYVIYAPVDIIAMNVVLSGGDPDYVALLPSGFAILPDGSARGGGGSANASAGAGVEGGGEGNNLEVVTTTGSCGGSLLTVAFQILVDSVPTAKLSLGSVATVNSLIKCTVERIKAALACDGA
homeobox-leucine zipper protein MERISTEM L1
Refseq ID NP_193906
Protein GI 22328861
UniProt ID Q8RWU4
mRNA ID NM_118295
Length 762
RefSeq Status REVIEWED
Protein sequence is identical to GI:79325215 (mRNA isoform)

Gene Information

Entrez Gene ID
828263
Gene Name
homeobox-leucine zipper protein MERISTEM L1
Gene Symbol
ATML1
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0003677 ISS:TAIR F DNA binding
GO:0008289 IEA:InterPro F lipid binding
GO:0043565 IDA:TAIR F sequence-specific DNA binding
GO:0003700 ISS:TAIR F sequence-specific DNA binding transcription factor activity
GO:0048825 IGI:TAIR P cotyledon development
GO:0009913 IGI:TAIR P epidermal cell differentiation
GO:0006351 IEA:UniProtKB-KW P transcription, DNA-templated

Domain Information

InterPro Annotations

Accession Description
IPR001356 Homeobox domain
IPR017970 Homeobox, conserved site
IPR009057 Homeodomain-like
IPR023393 START-like domain
IPR002913 START_lipid-bd_dom

UniProt Annotations

Entry Information

Gene Name
homeobox-leucine zipper protein MERISTEM L1
Protein Entry
ATML1_ARATH
UniProt ID
Q8RWU4
Species
Arabidopsis

Comments

Comment Type Description
Developmental Stage First expressed in the apical cell after the first asymmetric division of the zygote. Expressed in all proembryo cells until the eight-cell stage, and then restricted to the protoderm in the 16-cell proembryo. Not detected in the torpedo stage, but reappeared later in the L1 layer of the shoot apical meristem in the mature embryo. After germination, the L1 layer-specific expression pattern is maintained in the vegetative shoot apical meristem, inflorescence, floral meristems, and the young floral organ primordia. Finally, expressed in the protoderm of the ovule primordia and integuments and gradually restricted to the endothelium surrounding the embryo sac. {ECO:0000269|PubMed:10571886, ECO:0000269|PubMed:8989876}.
Function Probable transcription factor involved in cell specification and pattern formation during embryogenesis. Binds to the L1 box DNA sequence 5'-TAAATG[CT]A-3'. Plays a role in maintaining the identity of L1 cells, possibly by interacting with their L1 box or other target-gene promoters. Functionally redundant to PDF2. {ECO:0000269|PubMed:11439135, ECO:0000269|PubMed:12505995}.
Sequence Caution Sequence=AAB49378.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact leading to a deletion into the sequence.; Evidence={ECO:0000305}; Sequence=CAB36819.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAB81282.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity Belongs to the HD-ZIP homeobox family. Class IV subfamily. {ECO:0000305}.
Similarity Contains 1 START domain. {ECO:0000255|PROSITE- ProRule:PRU00197}.
Similarity Contains 1 homeobox DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00108}.
Subcellular Location Nucleus {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010485 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
79325215 RefSeq NP_001031692 762 homeobox-leucine zipper protein MERISTEM L1

Identical Sequences to LMP010485 proteins

Reference Database Accession Length Protein Name
GI:79325215 DBBJ BAF01795.1 762 L1 specific homeobox gene ATML1/ovule-specific homeobox protein A20 [Arabidopsis thaliana]
GI:79325215 GenBank ACW97971.1 762 Sequence 18440 from patent US 7569389
GI:79325215 GenBank ACW99661.1 762 Sequence 20746 from patent US 7569389
GI:79325215 GenBank AEE84498.1 762 homeobox-leucine zipper protein MERISTEM L1 [Arabidopsis thaliana]
GI:79325215 GenBank AEE84499.1 762 homeobox-leucine zipper protein MERISTEM L1 [Arabidopsis thaliana]
GI:79325215 SwissProt Q8RWU4.1 762 RecName: Full=Homeobox-leucine zipper protein MERISTEM L1; AltName: Full=HD-ZIP protein ATML1; AltName: Full=Homeodomain transcription factor ATML1 [Arabidopsis thaliana]

Related Sequences to LMP010485 proteins

Reference Database Accession Length Protein Name
GI:79325215 GenBank ACW97972.1 757 Sequence 18441 from patent US 7569389
GI:79325215 GenBank ACW97973.1 750 Sequence 18442 from patent US 7569389
GI:79325215 GenBank ACW99662.1 757 Sequence 20747 from patent US 7569389
GI:79325215 GenBank ACW99663.1 750 Sequence 20748 from patent US 7569389
GI:79325215 GenBank EOA18374.1 762 hypothetical protein CARUB_v10006895mg [Capsella rubella]
GI:79325215 RefSeq XP_006285476.1 762 hypothetical protein CARUB_v10006895mg [Capsella rubella]