Gene/Proteome Database (LMPD)

LMPD ID
LMP010514
Gene ID
831539
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
inositol-tetrakisphosphate 1-kinase 1
Gene Symbol
AT5G16760
Synonyms
3; 4-TRISPHOSPHATE 5/6-KINASE; INOSITOL 1
Alternate Names
inositol-tetrakisphosphate 1-kinase 1
Chromosome
5
EC Number
2.7.1.134

Proteins

inositol-tetrakisphosphate 1-kinase 1
Refseq ID NP_197178
Protein GI 15237403
UniProt ID Q9SBA5
mRNA ID NM_121682
Length 319
RefSeq Status REVIEWED
MSDSIQERYLVGYALAAKKQHSFIQPSLIEHSRQRGIDLVKLDPTKSLLEQGKLDCIIHKLYDVYWKENLHEFREKCPGVPVIDLPEAIERLHNRVSMLEVITQLRFPVSDSERFGVPEQVVVMDSSVLSGGGALGELKFPVIAKPLDADGSAKSHKMFLIYDQEGMKILKAPIVLQEFVNHGGVIFKVYVVGDHVKCVKRRSLPDISEEKIGTSKGSLPFSQISNLTAQEDKNIEYGEDRSLEKVEMPPLSFLTDLAKAMRESMGLNLFNFDVIRDAKDANRYLIIDINYFPGYAKMPSYEPVLTEFFWDMVTKKNHV

Gene Information

Entrez Gene ID
831539
Gene Name
inositol-tetrakisphosphate 1-kinase 1
Gene Symbol
AT5G16760
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:TAIR C cytosol
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0047325 IEA:UniProtKB-EC F inositol tetrakisphosphate 1-kinase activity
GO:0052726 IDA:TAIR F inositol-1,3,4-trisphosphate 5-kinase activity
GO:0052725 IDA:TAIR F inositol-1,3,4-trisphosphate 6-kinase activity
GO:0000287 IEA:InterPro F magnesium ion binding
GO:0052746 IDA:TAIR P inositol phosphorylation
GO:0032957 IEA:InterPro P inositol trisphosphate metabolic process
GO:0010264 IMP:TAIR P myo-inositol hexakisphosphate biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ath00562 Inositol phosphate metabolism
ath_M00132 Inositol phosphate metabolism, Ins(1,3,4)P3 => phytate

REACTOME Pathway Links

REACTOME Pathway ID Description
6254351 Synthesis of IP3 and IP4 in the cytosol
6254352 Synthesis of pyrophosphates in the cytosol

Domain Information

InterPro Annotations

Accession Description
IPR011761 ATP-grasp fold
IPR008656 Inositol-tetrakisphosphate 1-kinase
IPR017427 Inositol-tetrakisphosphate 1-kinase, plant

UniProt Annotations

Entry Information

Gene Name
inositol-tetrakisphosphate 1-kinase 1
Protein Entry
ITPK1_ARATH
UniProt ID
Q9SBA5
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate. {ECO:0000269|PubMed:9126335}.
Catalytic Activity ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate. {ECO:0000269|PubMed:9126335}.
Catalytic Activity ATP + 1D-myo-inositol 3,4,5,6- tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6- pentakisphosphate. {ECO:0000269|PubMed:9126335}.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 2 magnesium ions per subunit. {ECO:0000250};
Function Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not (By similarity). Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. {ECO:0000250}.
Similarity Belongs to the ITPK1 family. {ECO:0000305}.
Similarity Contains 1 ATP-grasp domain. {ECO:0000255|PROSITE- ProRule:PRU00409}.
Subunit Monomer. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010514 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15237403 RefSeq NP_197178 319 inositol-tetrakisphosphate 1-kinase 1

Identical Sequences to LMP010514 proteins

Reference Database Accession Length Protein Name
GI:15237403 GenBank AAM20052.1 319 putative inositol 1,3,4-trisphosphate 5/6 kinase [Arabidopsis thaliana]
GI:15237403 GenBank AAM64585.1 319 inositol 1,3,4-Trisphosphate 5/6 kinase [Arabidopsis thaliana]
GI:15237403 GenBank AAY01564.1 319 Sequence 34 from patent US 6855869
GI:15237403 GenBank ABW56892.1 319 Sequence 34 from patent US 7271317
GI:15237403 gnl TAIR 319 inositol-tetrakisphosphate 1-kinase 1 [Arabidopsis thaliana]
GI:15237403 SwissProt Q9SBA5.1 319 RecName: Full=Inositol-tetrakisphosphate 1-kinase 1; AltName: Full=Inositol 1,3,4-trisphosphate 5/6-kinase 1; Short=AtItpk-1; Short=Inositol-triphosphate 5/6-kinase 1; Short=Ins(1,3,4)P(3) 5/6-kinase 1 [Arabidopsis thaliana]

Related Sequences to LMP010514 proteins

Reference Database Accession Length Protein Name
GI:15237403 GenBank AAC28859.1 319 inositol 1,3,4-trisphosphate 5/6-kinase [Arabidopsis thaliana]
GI:15237403 GenBank AAY01563.1 319 Sequence 33 from patent US 6855869
GI:15237403 GenBank ABW56891.1 319 Sequence 33 from patent US 7271317
GI:15237403 GenBank EFH47994.1 320 inositol 1,3,4-trisphosphate 5/6-kinase [Arabidopsis lyrata subsp. lyrata]
GI:15237403 GenBank EOA21132.1 319 hypothetical protein CARUB_v10001475mg [Capsella rubella]
GI:15237403 RefSeq XP_006288234.1 319 hypothetical protein CARUB_v10001475mg [Capsella rubella]