Gene/Proteome Database (LMPD)

LMPD ID
LMP010525
Gene ID
837919
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
ceramide synthase LAG1
Gene Symbol
LAG13
Synonyms
F13B4.7; F13B4_7; LAG1 longevity assurance homolog 3; LAG13
Alternate Names
ceramide synthase LAG1
Chromosome
1

Proteins

ceramide synthase LAG1
Refseq ID NP_172815
Protein GI 30683361
UniProt ID Q6NQI8
mRNA ID NM_101228
Length 239
RefSeq Status REVIEWED
MGLLESVKSINWEHESSPVYQDFRVLPLFAVFFPSIRFLLDRFVFEKLAKYLIYGKHRQDMGDDTTERKKKIRKFKESAWKCVYYLSAEILALSVTYNEPWFMNTKYFWVGPGDQTWPDQQTKLKLKLLYMFVAGFYTYSIFALVFWETRRSDFGVSMGHHIATLILIVLSYVCSFSRVGSVVLALHDASDVFLEVGKMSKYSGAERIASFSFILFVLSWIILRLIYYPFWILWSTRFV
ceramide synthase LAG1
Refseq ID NP_001031037
Protein GI 79317904
UniProt ID Q6NQI8
mRNA ID NM_001035960
Length 308
RefSeq Status REVIEWED
MGLLESVKSINWEHESSPVYQDFRVLPLFAVFFPSIRFLLDRFVFEKLAKYLIYGKHRQDMGDDTTERKKKIRKFKESAWKCVYYLSAEILALSVTYNEPWFMNTKYFWVGPGDQTWPDQQTKLKLKLLYMFVAGFYTYSIFALVFWETRRSDFGVSMGHHIATLILIVLSYVCSFSRVGSVVLALHDASDVFLEVGKMSKYSGAERIASFSFILFVLSWIILRLIYYPFWILWSTSYEVVLELDKDKHPIEGPIYYYMFNTLLYCLLVLHIYWWVLMYRMLVKQIQDRGKLSEDVRSDSEGEDEHED
ceramide synthase LAG1
Refseq ID NP_001184985
Protein GI 334182555
UniProt ID Q6NQI8
mRNA ID NM_001198056
Length 308
RefSeq Status REVIEWED
Protein sequence is identical to GI:79317904 (mRNA isoform)

Gene Information

Entrez Gene ID
837919
Gene Name
ceramide synthase LAG1
Gene Symbol
LAG13
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:TAIR C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0050291 IGI:TAIR F sphingosine N-acyltransferase activity
GO:0042761 IGI:TAIR P very long-chain fatty acid biosynthetic process

REACTOME Pathway Links

REACTOME Pathway ID Description
6253653 Metabolism
6253725 Metabolism of lipids and lipoproteins
6254191 Sphingolipid de novo biosynthesis
6254192 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR016439 Longevity assurance, LAG1/LAC1
IPR006634 TRAM/LAG1/CLN8 homology domain

UniProt Annotations

Entry Information

Gene Name
ceramide synthase LAG1
Protein Entry
LAG13_ARATH
UniProt ID
Q6NQI8
Species
Arabidopsis

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6NQI8-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q6NQI8-2; Sequence=VSP_013449, VSP_013450; Note=May be due to intron retention. No experimental confirmation available.;
Function Mediates resistance to sphinganine-analog mycotoxins (SAMs) by restoring the sphingolipid biosynthesis. Could salvage the transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi apparatus in ceramides-depleted cells after SAM exposure (By similarity). {ECO:0000250}.
Similarity Contains 1 TLC (TRAM/LAG1/CLN8) domain. {ECO:0000255|PROSITE-ProRule:PRU00205}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010525 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
79317904 RefSeq NP_001031037 308 ceramide synthase LAG1
30683361 RefSeq NP_172815 239 ceramide synthase LAG1

Identical Sequences to LMP010525 proteins

Reference Database Accession Length Protein Name
GI:79317904 GenBank AAF99825.1 308 Highly similar to fungal resistance protein Asc [Arabidopsis thaliana]
GI:30683361 GenBank AAQ65088.1 239 At1g13580/F13B4_25 [Arabidopsis thaliana]
GI:30683361 GenBank AEE29036.1 239 LAG1 longevity assurance homolog 3 [Arabidopsis thaliana]
GI:79317904 GenBank AEE29037.1 308 LAG1 longevity assurance homolog 3 [Arabidopsis thaliana]
GI:79317904 GenBank AEE29038.1 308 LAG1 longevity assurance homolog 3 [Arabidopsis thaliana]
GI:79317904 RefSeq NP_001184985.1 308 ceramide synthase LAG1 [Arabidopsis thaliana]
GI:79317904 SwissProt Q6NQI8.2 308 RecName: Full=LAG1 longevity assurance homolog 3; Short=LAG1 homolog 3 [Arabidopsis thaliana]

Related Sequences to LMP010525 proteins

Reference Database Accession Length Protein Name
GI:79317904 DBBJ BAH56987.1 308 AT1G13580 [Arabidopsis thaliana]
GI:30683361 GenBank AAF99825.1 308 Highly similar to fungal resistance protein Asc [Arabidopsis thaliana]
GI:79317904 GenBank EFH69019.1 308 hypothetical protein ARALYDRAFT_471517 [Arabidopsis lyrata subsp. lyrata]
GI:30683361 GenBank AEE29037.1 308 LAG1 longevity assurance homolog 3 [Arabidopsis thaliana]
GI:30683361 GenBank AEE29038.1 308 LAG1 longevity assurance homolog 3 [Arabidopsis thaliana]
GI:79317904 GenBank EOA38761.1 308 hypothetical protein CARUB_v10010947mg [Capsella rubella]
GI:30683361 RefSeq NP_001031037.1 308 ceramide synthase LAG1 [Arabidopsis thaliana]
GI:79317904 RefSeq XP_002892760.1 308 hypothetical protein ARALYDRAFT_471517 [Arabidopsis lyrata subsp. lyrata]
GI:30683361 RefSeq NP_001184985.1 308 ceramide synthase LAG1 [Arabidopsis thaliana]
GI:79317904 RefSeq XP_006305863.1 308 hypothetical protein CARUB_v10010947mg [Capsella rubella]
GI:79317904 RefSeq XP_010476360.1 308 PREDICTED: LAG1 longevity assurance homolog 3 isoform X1 [Camelina sativa]
GI:30683361 SwissProt Q6NQI8.2 308 RecName: Full=LAG1 longevity assurance homolog 3; Short=LAG1 homolog 3 [Arabidopsis thaliana]