Gene/Proteome Database (LMPD)

LMPD ID
LMP010555
Gene ID
838314
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
lipoxygenase 3
Gene Symbol
LOX3
Synonyms
F28G4.10; lipoxygenase 3; LOX3
Alternate Names
lipoxygenase 3
Chromosome
1
EC Number
1.13.11.12
Summary
Lipoxygenase
Orthologs
View orthologs and multiple alignments for LOX3

Proteins

lipoxygenase 3
Refseq ID NP_564021
Protein GI 18394479
UniProt ID Q9LNR3
mRNA ID NM_101603
Length 919
RefSeq Status REVIEWED
MALAKELMGYPLITERSSLVSSASHFKKRTQSTQFSINPFDRRPRKTKSGVVAAISEDLVKTLRFSTTTGDRKSEEEEKAAVKFKVRAVVTVRNKNKEDLKETLVKHLDAFADKIGRNIVLELISTQLDPKTKLPKKSNAAVLKDWSKKSKTKAERVHYTAEFTVDAAFGSPGAITVMNKHQKEFFLESITIEGFALGPVHFPCNSWVQSQKDHPDKRIFFTNQPYLPNETPSGLRVLREKELKNLRGDGSGVRKLSDRIYDFDVYNDLGNPDKSSELSRPKLGGKEVPYPRRCRTGRQSTVSDKDAESRVEKPLPMYVPRDEQFEESKQDTFAAGRLKAVLHHLIPSLKASIVAEDFADFGEIDRLYKEGLLLKLGFQDDIFKKFPLPKVVVDTLQESTKGLLKYDTPKILSKDKNAWLRDDEFARQAIAGINPVNIERVKTFPPVSNLDPKIYGPQHSALTDDHIIGHLDGFSVQQALEENRLYMLDYHDIFLPFLDRINALDGRKAYATRTIFFLTRLGTLKPVAIELSLPPHGPKHRSKRVLTPPVDATSNWMWQLAKAHVSSNDAGVHQLVNHWLRTHACLEPFILAAHRQLSAMHPIFKLLDPHMRYTLEINALARQSLISADGVIEGGFTAGAYGMEMSAAAYKSSWRFDMEGLPADLIRRGMAIPDATQPHGLKLLIEDYPYANDGLLLWSAIQTWVRTYVERYYPNPNLIKTDSELQSWYSESINVGHADLRDADWWPELSTVDDLVSILTTLIWLASAQHAALNFGQYPYGGYVPNRPPLMRRLIPDESDPEYASFISHPEKYYFSSMPSLAQTSKFMAVVDTLSTHSPDEEYIGERQQPSIWTGDAEIVEAFYGFAAEIGRIEKEIEKRNADPDRRNRCGAGVLPYELLVPSSEPGVTCRGVPNSVSI

Gene Information

Entrez Gene ID
838314
Gene Name
lipoxygenase 3
Gene Symbol
LOX3
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009507 IEA:UniProtKB-KW C chloroplast
GO:0005506 IEA:InterPro F iron ion binding
GO:0016165 IDA:UniProtKB F linoleate 13S-lipoxygenase activity
GO:0009901 IGI:TAIR P anther dehiscence
GO:0048653 IGI:TAIR P anther development
GO:0034440 IDA:TAIR P lipid oxidation
GO:0031408 IEA:UniProtKB-UniPathway P oxylipin biosynthetic process
GO:0009555 IGI:TAIR P pollen development
GO:0009620 IEP:TAIR P response to fungus
GO:0009644 IEP:UniProtKB P response to high light intensity
GO:0009753 IEP:UniProtKB P response to jasmonic acid
GO:0009611 IEP:UniProtKB P response to wounding
GO:0080086 IGI:TAIR P stamen filament development

KEGG Pathway Links

KEGG Pathway ID Description
ath_M00113 Jasmonic acid biosynthesis
ath00591 Linoleic acid metabolism
ath00592 alpha-Linolenic acid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
6254368 Synthesis of Lipoxins (LX)

Domain Information

InterPro Annotations

Accession Description
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR000907 Lipoxygenase
IPR013819 Lipoxygenase, C-terminal
IPR020834 Lipoxygenase, conserved site
IPR027433 Lipoxygenase, domain 3
IPR020833 Lipoxygenase, iron binding site
IPR001246 Lipoxygenase, plant
IPR001024 PLAT/LH2 domain

UniProt Annotations

Entry Information

Gene Name
lipoxygenase 3
Protein Entry
LOX3_ARATH
UniProt ID
Q9LNR3
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity Alpha-linolenate + O(2) = (9Z,11E,13S,15Z)-13- hydroperoxyoctadeca-9,11,15-trienoate.
Catalytic Activity Linoleate + O(2) = (9Z,11E,13S)-13- hydroperoxyoctadeca-9,11-dienoate.
Cofactor Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000255|PROSITE-ProRule:PRU00726}; Note=Binds 1 Fe cation per subunit. {ECO:0000255|PROSITE- ProRule:PRU00726};
Developmental Stage First observed in lateral root primordia (LRP), from the first pericycle divisions. Later expressed in lateral roots. Expression is greatly increased in leaves during leaf senescence. {ECO:0000269|PubMed:11891244, ECO:0000269|PubMed:17369372}.
Function 13S-lipoxygenase that can use linolenic acid as substrates. Plant lipoxygenases may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. Catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure (By similarity). {ECO:0000250}.
Induction Induced by methyl jasmonate (MeJA), bacterial pathogens (e.g. Pseudomonas syringae pv. tomato), high light and wounding. {ECO:0000269|PubMed:17786451, ECO:0000269|PubMed:18156220, ECO:0000269|PubMed:18216250}.
Pathway Lipid metabolism; oxylipin biosynthesis. {ECO:0000255|PROSITE-ProRule:PRU00726}.
Sequence Caution Sequence=AAF97315.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the lipoxygenase family. {ECO:0000305}.
Similarity Contains 1 PLAT domain. {ECO:0000255|PROSITE- ProRule:PRU00152}.
Similarity Contains 1 lipoxygenase domain. {ECO:0000255|PROSITE- ProRule:PRU00726}.
Subcellular Location Plastid, chloroplast {ECO:0000305}.
Tissue Specificity Expressed in roots and leaves. {ECO:0000269|PubMed:17369372}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010555 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18394479 RefSeq NP_564021 919 lipoxygenase 3

Identical Sequences to LMP010555 proteins

Reference Database Accession Length Protein Name
GI:18394479 GenBank AAF79461.1 919 F1L3.11 [Arabidopsis thaliana]
GI:18394479 GenBank AAL91636.1 919 At1g17420/F1L3_1 [Arabidopsis thaliana]
GI:18394479 GenBank AAP21156.1 919 At1g17420/F1L3_1 [Arabidopsis thaliana]
GI:18394479 GenBank ADT59632.1 919 Sequence 154 from patent US 7847156
GI:18394479 GenBank AEE29585.1 919 lipoxygenase 3 [Arabidopsis thaliana]
GI:18394479 SwissProt Q9LNR3.1 919 RecName: Full=Lipoxygenase 3, chloroplastic; Short=AtLOX3; Flags: Precursor [Arabidopsis thaliana]

Related Sequences to LMP010555 proteins

Reference Database Accession Length Protein Name
GI:18394479 EMBL CAB56692.1 919 lipoxygenase [Arabidopsis thaliana]
GI:18394479 GenBank AAF97315.1 912 lipoxygenase [Arabidopsis thaliana]
GI:18394479 GenBank EFH66483.1 919 hypothetical protein ARALYDRAFT_471947 [Arabidopsis lyrata subsp. lyrata]
GI:18394479 RefSeq XP_002890224.1 919 hypothetical protein ARALYDRAFT_471947 [Arabidopsis lyrata subsp. lyrata]
GI:18394479 RefSeq XP_006306718.1 921 hypothetical protein CARUB_v10008244mg [Capsella rubella]
GI:18394479 RefSeq XP_010476891.1 920 PREDICTED: lipoxygenase 3, chloroplastic [Camelina sativa]