Gene/Proteome Database (LMPD)
LMPD ID
LMP010566
Gene ID
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
long-chain acyl-CoA synthetase 6
Gene Symbol
Synonyms
ATLACS6; F2O10.7; F2O10_7; LACS6; long-chain acyl-CoA synthetase 6
Alternate Names
long-chain acyl-CoA synthetase 6
Chromosome
3
EC Number
6.2.1.3
Summary
encode peroxisomal long-chain acyl-CoA synthetase (LACS) isozymes
Orthologs
Proteins
| long-chain acyl-CoA synthetase 6 | |
|---|---|
| Refseq ID | NP_566265 |
| Protein GI | 18397422 |
| UniProt ID | Q8LPS1 |
| mRNA ID | NM_111471 |
| Length | 701 |
| RefSeq Status | REVIEWED |
| MDSSSSSSSAAARRRINAIHSHLVTSSRSSPLLRSNPTAGEFCLDNGYSVVLPEKLNTGSWNVYRSAKSPFKLVSRFPDHPDIATLHDNFEHAVHDFRDYKYLGTRVRVDGTVGDYKWMTYGEAGTARTALGSGLVHHGIPMGSSVGIYFINRPEWLIVDHACSSYSYVSVPLYDTLGPDAVKFIVNHATVQAIFCVAETLNSLLSCLSEMPSVRLVVVVGGLIESLPSLPSSSGVKVVSYSVLLNQGRSNPQRFFPPKPDDVATICYTSGTTGTPKGVVLTHANLIANVAGSSFSVKFFSSDVYISYLPLAHIYERANQILTVYFGVAVGFYQGDNMKLLDDLAALRPTVFSSVPRLYNRIYAGIINAVKTSGGLKERLFNAAYNAKKQALLNGKSASPIWDRLVFNKIKDRLGGRVRFMTSGASPLSPEVMEFLKVCFGGRVTEGYGMTETSCVISGMDEGDNLTGHVGSPNPACEVKLVDVPEMNYTSADQPHPRGEICVRGPIIFTGYYKDEIQTKEVIDEDGWLHTGDIGLWLPGGRLKIIDRKKNIFKLAQGEYIAPEKIENVYAKCKFVGQCFIYGDSFNSSLVAVVSVDPDVLKSWAASEGIKGGDLRELCNNPRVKAAVLSDMDTVGREAQLRGFEFAKAVTLVLEPFTLENGLLTPTFKIKRPQAKEYFAEAITNMYKELGASDPSANRGL | |
Gene Information
Entrez Gene ID
Gene Name
long-chain acyl-CoA synthetase 6
Gene Symbol
Species
Arabidopsis thaliana
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0009514 | IEA:UniProtKB-KW | C | glyoxysome |
| GO:0016020 | IDA:TAIR | C | membrane |
| GO:0005777 | IDA:UniProtKB | C | peroxisome |
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
| GO:0004467 | IDA:UniProtKB | F | long-chain fatty acid-CoA ligase activity |
| GO:0006631 | TAS:UniProtKB | P | fatty acid metabolic process |
| GO:0007275 | IEA:UniProtKB-KW | P | multicellular organismal development |
| GO:0010193 | IEP:UniProtKB | P | response to ozone |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ath_M00086 | beta-Oxidation, acyl-CoA synthesis |
| ath00061 | Fatty acid biosynthesis |
| ath00071 | Fatty acid degradation |
| ath04146 | Peroxisome |
Domain Information
UniProt Annotations
Entry Information
Gene Name
long-chain acyl-CoA synthetase 6
Protein Entry
LACS6_ARATH
UniProt ID
Species
Arabidopsis
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA. {ECO:0000269|PubMed:12177484, ECO:0000269|PubMed:12366803}. |
| Cofactor | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; |
| Developmental Stage | Induced during seed germination. {ECO:0000269|PubMed:12366803}. |
| Disruption Phenotype | Seedlings of the lacs6 and lacs7 double mutant were arrested in postgerminative growth due to inability to mobilize fatty acids into beta-oxidation, a necessary process to pursue the development. {ECO:0000269|PubMed:14742880}. |
| Function | Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitate, palmitoleate, oleate, linoleate and eicosenoate. Might play a regulatory role both in fatty acid import into glyoxysomes and in fatty acid beta-oxidation. Displays redundant function with LACS7 into the seed development process. {ECO:0000269|PubMed:12481085, ECO:0000269|PubMed:14742880}. |
| Induction | Up-regulated by ozone. {ECO:0000269|PubMed:16256065}. |
| Pathway | Lipid metabolism; fatty acid metabolism. |
| Sequence Caution | Sequence=AAF23219.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; |
| Similarity | Belongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}. |
| Subcellular Location | Peroxisome {ECO:0000269|PubMed:12366803, ECO:0000269|PubMed:12481085}. Glyoxysome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. |
| Tissue Specificity | Preferentially expressed in seeds and senescent leaves. {ECO:0000269|PubMed:16256065}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP010566 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 18397422 | RefSeq | NP_566265 | 701 | long-chain acyl-CoA synthetase 6 |
Identical Sequences to LMP010566 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:18397422 | GenBank | AAM19792.1 | 701 | AT3g05970/F2O10_9 [Arabidopsis thaliana] |
| GI:18397422 | GenBank | AAN64508.1 | 701 | At3g05970/F2O10_9 [Arabidopsis thaliana] |
| GI:18397422 | GenBank | AEE74324.1 | 701 | long-chain acyl-CoA synthetase 6 [Arabidopsis thaliana] |
| GI:18397422 | SwissProt | Q8LPS1.1 | 701 | RecName: Full=Long chain acyl-CoA synthetase 6, peroxisomal; Flags: Precursor [Arabidopsis thaliana] |
Related Sequences to LMP010566 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:18397422 | DBBJ | BAB40450.1 | 701 | long-chain acyl-CoA synthetase [Arabidopsis thaliana] |
| GI:18397422 | EMBL | CBF65068.1 | 701 | unnamed protein product [Arabidopsis thaliana] |
| GI:18397422 | EMBL | CBU89939.1 | 701 | unnamed protein product [Arabidopsis thaliana] |
| GI:18397422 | GenBank | AAM28873.1 | 701 | long chain acyl-CoA synthetase 6 [Arabidopsis thaliana] |
| GI:18397422 | GenBank | ABJ40759.1 | 701 | Sequence 16 from patent US 7105722 |
| GI:18397422 | GenBank | AGX56968.1 | 701 | Sequence 14255 from patent US 8541208 |