Gene/Proteome Database (LMPD)

LMPD ID
LMP010567
Gene ID
832820
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
long-chain acyl-CoA synthetase 7
Gene Symbol
LACS7
Synonyms
ATLACS7; F15A18.60; F15A18_60; LACS7; long-chain acyl-CoA synthetase 7
Alternate Names
long-chain acyl-CoA synthetase 7
Chromosome
5
EC Number
6.2.1.3

Proteins

long-chain acyl-CoA synthetase 7
Refseq ID NP_198112
Protein GI 22327099
UniProt ID Q8LKS5
mRNA ID NM_122642
Length 700
RefSeq Status REVIEWED
MEFASPEQRRLETIRSHIDTSPTNDQSSSLFLNATASSASPFFKEDSYSVVLPEKLDTGKWNVYRSKRSPTKLVSRFPDHPEIGTLHDNFVHAVETYAENKYLGTRVRSDGTIGEYSWMTYGEAASERQAIGSGLLFHGVNQGDCVGLYFINRPEWLVVDHACAAYSFVSVPLYDTLGPDAVKFVVNHANLQAIFCVPQTLNILLSFLAEIPSIRLIVVVGGADEHLPSLPRGTGVTIVSYQKLLSQGRSSLHPFSPPKPEDIATICYTSGTTGTPKGVVLTHGNLIANVAGSSVEAEFFPSDVYISYLPLAHIYERANQIMGVYGGVAVGFYQGDVFKLMDDFAVLRPTIFCSVPRLYNRIYDGITSAVKSSGVVKKRLFEIAYNSKKQAIINGRTPSAFWDKLVFNKIKEKLGGRVRFMGSGASPLSPDVMDFLRICFGCSVREGYGMTETSCVISAMDDGDNLSGHVGSPNPACEVKLVDVPEMNYTSDDQPYPRGEICVRGPIIFKGYYKDEEQTREILDGDGWLHTGDIGLWLPGGRLKIIDRKKNIFKLAQGEYIAPEKIENVYTKCRFVSQCFIHGDSFNSSLVAIVSVDPEVMKDWAASEGIKYEHLGQLCNDPRVRKTVLAEMDDLGREAQLRGFEFAKAVTLVPEPFTLENGLLTPTFKIKRPQAKAYFAEAISKMYAEIAASNPIPSKL

Gene Information

Entrez Gene ID
832820
Gene Name
long-chain acyl-CoA synthetase 7
Gene Symbol
LACS7
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005777 IDA:UniProtKB C peroxisome
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004467 IDA:UniProtKB F long-chain fatty acid-CoA ligase activity
GO:0006631 TAS:UniProtKB P fatty acid metabolic process
GO:0001676 IDA:GOC P long-chain fatty acid metabolic process
GO:0010193 IEP:TAIR P response to ozone
GO:0009651 IEP:TAIR P response to salt stress

KEGG Pathway Links

KEGG Pathway ID Description
ath00061 Fatty acid biosynthesis
ath00071 Fatty acid degradation
ath04146 Peroxisome
ath_M00086 beta-Oxidation, acyl-CoA synthesis

Domain Information

InterPro Annotations

Accession Description
IPR020845 AMP-binding, conserved site
IPR000873 AMP-dependent synthetase/ligase

UniProt Annotations

Entry Information

Gene Name
long-chain acyl-CoA synthetase 7
Protein Entry
LACS7_ARATH
UniProt ID
Q8LKS5
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA. {ECO:0000269|PubMed:12177484, ECO:0000269|PubMed:12366803}.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Developmental Stage Induced during seed germination. {ECO:0000269|PubMed:12366803}.
Disruption Phenotype Seedlings of the lacs6 and lacs7 double mutant were arrested in postgerminative growth due to inability to mobilize fatty acids into beta-oxidation, a necessary process to pursue the development. {ECO:0000269|PubMed:14742880}.
Function Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitate, palmitoleate, oleate, linoleate and eicosenoate. Displays redundant function with LACS7 into the seed development process (By similarity). {ECO:0000250}.
Induction Up-regulated by ozone and salt. {ECO:0000269|PubMed:16256065}.
Interaction Q9FMA3:PEX5; NbExp=4; IntAct=EBI-993851, EBI-993861;
Pathway Lipid metabolism; fatty acid metabolism.
Sequence Caution Sequence=BAC43213.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Similarity Belongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.
Subcellular Location Peroxisome {ECO:0000269|PubMed:12366803}.
Subunit Interacts with PEX5. {ECO:0000269|PubMed:16256065}.
Tissue Specificity Preferentially expressed in seeds. {ECO:0000269|PubMed:16256065}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010567 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
22327099 RefSeq NP_198112 700 long-chain acyl-CoA synthetase 7

Identical Sequences to LMP010567 proteins

Reference Database Accession Length Protein Name
GI:22327099 GenBank ABJ40799.1 700 Sequence 130 from patent US 7105722
GI:22327099 GenBank ADT59737.1 700 Sequence 364 from patent US 7847156
GI:22327099 gnl TAIR 700 long-chain acyl-CoA synthetase 7 [Arabidopsis thaliana]
GI:22327099 SwissProt Q8LKS5.2 700 RecName: Full=Long chain acyl-CoA synthetase 7, peroxisomal [Arabidopsis thaliana]

Related Sequences to LMP010567 proteins

Reference Database Accession Length Protein Name
GI:22327099 EMBL CBF65067.1 700 unnamed protein product [Arabidopsis thaliana]
GI:22327099 EMBL CBU89938.1 700 unnamed protein product [Arabidopsis thaliana]
GI:22327099 GenBank AAM28874.1 700 long chain acyl-CoA synthetase 7 [Arabidopsis thaliana]
GI:22327099 GenBank ABJ40760.1 700 Sequence 17 from patent US 7105722
GI:22327099 GenBank AGX56967.1 700 Sequence 14253 from patent US 8541208
GI:22327099 RefSeq XP_002874363.1 699 long-chain acyl-CoA synthetase 7 [Arabidopsis lyrata subsp. lyrata]