Gene/Proteome Database (LMPD)
Proteins
| lysophosphatidylcholine acyltransferase 1 | |
|---|---|
| Refseq ID | NP_172724 |
| Protein GI | 22329514 |
| UniProt ID | F4IDU4 |
| mRNA ID | NM_101134 |
| Length | 462 |
| RefSeq Status | REVIEWED |
| MDMSSMAGSIGVSVAVLRFLLCFVATIPVSFACRIVPSRLGKHLYAAASGAFLSYLSFGFSSNLHFLVPMTIGYASMAIYRPKCGIITFFLGFAYLIGCHVFYMSGDAWKEGGIDSTGALMVLTLKVISCSMNYNDGMLKEEGLREAQKKNRLIQMPSLIEYFGYCLCCGSHFAGPVYEMKDYLEWTEGKGIWDTTEKRKKPSPYGATIRAILQAAICMALYLYLVPQYPLTRFTEPVYQEWGFLRKFSYQYMAGFTARWKYYFIWSISEASIIISGLGFSGWTDDASPKPKWDRAKNVDILGVELAKSAVQIPLVWNIQVSTWLRHYVYERLVQNGKKAGFFQLLATQTVSAVWHGLYPGYMMFFVQSALMIAGSRVIYRWQQAISPKMAMLRNIMVFINFLYTVLVLNYSAVGFMVLSLHETLTAYGSVYYIGTIIPVGLILLSYVVPAKPSRPKPRKEE | |
Gene Information
Entrez Gene ID
Gene Name
lysophosphatidylcholine acyltransferase 1
Gene Symbol
Species
Arabidopsis thaliana
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005783 | IDA:TAIR | C | endoplasmic reticulum |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005886 | IDA:TAIR | C | plasma membrane |
| GO:0047184 | IEA:UniProtKB-EC | F | 1-acylglycerophosphocholine O-acyltransferase activity |
| GO:0071617 | IGI:TAIR | F | lysophospholipid acyltransferase activity |
| GO:0016746 | IDA:TAIR | F | transferase activity, transferring acyl groups |
| GO:0045017 | IMP:TAIR | P | glycerolipid biosynthetic process |
| GO:0008654 | IEA:UniProtKB-KW | P | phospholipid biosynthetic process |
| GO:0019432 | IGI:TAIR | P | triglyceride biosynthetic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ath00565 | Ether lipid metabolism |
| ath00561 | Glycerolipid metabolism |
| ath00564 | Glycerophospholipid metabolism |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 6254310 | Acyl chain remodelling of PI |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR004299 | Membrane bound O-acyl transferase, MBOAT |
UniProt Annotations
Entry Information
Gene Name
lysophosphatidylcholine acyltransferase 1
Protein Entry
MBOA1_ARATH
UniProt ID
Species
Arabidopsis
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Acyl-CoA + 1-acyl-sn-glycero-3- phosphatidylserine = CoA + 1,2-diacyl-sn-glycero-3- phosphatidylserine. |
| Catalytic Activity | Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine. |
| Catalytic Activity | Acyl-CoA + 1-acyl-sn-glycero-3- phosphoethanolamine = CoA + 1,2-diacyl-sn-glycero-3- phosphoethanolamine. |
| Disruption Phenotype | No visible phenotype under normal growth conditions, but the double mutants lpcat1 and lpcat2-2 show increased contents of very-long-chain fatty acids and decreased polyunsaturated fatty acids in seed triacylglycerols. {ECO:0000269|PubMed:22233193, ECO:0000269|PubMed:22932756, ECO:0000269|PubMed:23150634}. |
| Function | Lysophospholipid acyltransferase with broad specificity. Mediates the conversion of lysophosphatidylethanolamine (1-acyl- sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl-sn-glycero-3- phosphoethanolamine or PE) (LPEAT activity). Catalyzes the acylation of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero- 3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn- glycero-3-phospho-L-serine or PS) (LPSAT activity). Can convert lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3- phosphocholine or PC) (LPCAT activity) Can also utilizes lysophosphatidylglycerol (LPG) as substrate in vitro. Has neither activity towards lysophosphatidic acid (LPA) nor lysophosphatidylinositol (LPI). Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. The primary function of the Lands cycle is to provide a route for acyl remodeling to modify fatty acid (FA) composition of phospholipids derived from the Kennedy pathway. Is involved in PC acyl editing and phosphocholine headgroup exchange between PC and diacylglycerols. This processes control the majority of acyl fluxes through PC to provide polyunsaturated fatty acids for triacylglycerols synthesis in seeds. {ECO:0000269|PubMed:18154737, ECO:0000269|PubMed:22932756, ECO:0000269|PubMed:23150634}. |
| Sequence Caution | Sequence=AAF88094.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; |
| Similarity | Belongs to the membrane-bound acyltransferase family. {ECO:0000305}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000305|PubMed:22923678}; Multi-pass membrane protein {ECO:0000305|PubMed:22923678}. |
| Tissue Specificity | Expressed in roots, rosette leaves, petals, stigma, chalazal endosperm of developing seeds and vascular bundles of siliques. {ECO:0000269|PubMed:23150634}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP010587 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 22329514 | RefSeq | NP_172724 | 462 | lysophosphatidylcholine acyltransferase 1 |
Identical Sequences to LMP010587 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:22329514 | GenBank | AEE28904.1 | 462 | MBOAT (membrane bound O-acyl transferase)-like protein [Arabidopsis thaliana] |
| GI:22329514 | GenBank | AGM70818.1 | 462 | Sequence 4 from patent US 8383886 |
| GI:22329514 | GenBank | AGM70836.1 | 462 | Sequence 36 from patent US 8383886 |
| GI:22329514 | GenBank | AGM70854.1 | 462 | Sequence 54 from patent US 8383886 |
| GI:22329514 | GenBank | AGM70874.1 | 462 | Sequence 74 from patent US 8383886 |
| GI:22329514 | SwissProt | F4IDU4.1 | 462 | RecName: Full=Lysophospholipid acyltransferase 1; Short=AtLPLAT1; AltName: Full=1-acylglycerophosphocholine O-acyltransferase 1; AltName: Full=1-acylglycerophosphoethanolamine O-acyltransferase; AltName: Full=1-acylglycerophosphoserine O-acyltransferase; AltName: Full=Lysophosphatidylcholine acyltransferase 1; Short=LPCAT1; AltName: Full=Lysophosphatidylethanolamine acyltransferase; Short=LPEAT; AltName: Full=Lysophosphatidylglycerol acyltransferase; Short=LPGAT; AltName: Full=Lysophosphatidylserine acyltransferase; Short=LPSAT [Arabidopsis thaliana] |
Related Sequences to LMP010587 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:22329514 | GenBank | AAF88094.1 | 457 | T12C24.17 [Arabidopsis thaliana] |
| GI:22329514 | GenBank | AAM13086.1 | 462 | unknown protein [Arabidopsis thaliana] |
| GI:22329514 | GenBank | AAM91162.1 | 462 | unknown protein [Arabidopsis thaliana] |
| GI:22329514 | GenBank | EFH68959.1 | 462 | membrane bound O-acyl transferase family protein [Arabidopsis lyrata subsp. lyrata] |
| GI:22329514 | RefSeq | XP_002892700.1 | 462 | membrane bound O-acyl transferase family protein [Arabidopsis lyrata subsp. lyrata] |
| GI:22329514 | RefSeq | XP_006307436.1 | 465 | hypothetical protein CARUB_v10009061mg [Capsella rubella] |