Gene/Proteome Database (LMPD)

LMPD ID
LMP010589
Gene ID
844435
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
phospholipid/glycerol acyltransferase family protein
Gene Symbol
AT1G80950
Synonyms
F23A5.31; F23A5_31
Alternate Names
phospholipid/glycerol acyltransferase family protein
Chromosome
1
EC Number
2.3.1.25

Proteins

phospholipid/glycerol acyltransferase family protein
Refseq ID NP_565249
Protein GI 18412918
UniProt ID Q8L7R3
mRNA ID NM_106743
Length 398
RefSeq Status REVIEWED
MESELKDLNSNSNPPSSKEDRPLLKSESDLAAAIEELDKKFAPYARTDLYGTMGLGPFPMTENIKLAVALVTLVPLRFLLSMSILLLYYLICRVFTLFSAPYRGPEEEEDEGGVVFQEDYAHMEGWKRTVIVRSGRFLSRVLLFVFGFYWIHESCPDRDSDMDSNPKTTSTEINQKGEAATEEPERPGAIVSNHVSYLDILYHMSASFPSFVAKRSVGKLPLVGLISKCLGCVYVQREAKSPDFKGVSGTVNERVREAHSNKSAPTIMLFPEGTTTNGDYLLTFKTGAFLAGTPVLPVILKYPYERFSVAWDTISGARHILFLLCQVVNHLEVIRLPVYYPSQEEKDDPKLYASNVRKLMATEGNLILSELGLSDKRIYHATLNGNLSQTRDFHQKEE

Gene Information

Entrez Gene ID
844435
Gene Name
phospholipid/glycerol acyltransferase family protein
Gene Symbol
AT1G80950
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:TAIR C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005634 IDA:TAIR C nucleus
GO:0050200 IDA:UniProtKB F plasmalogen synthase activity
GO:0008654 IEA:UniProtKB-KW P phospholipid biosynthetic process
GO:0006644 IDA:UniProtKB P phospholipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ath00565 Ether lipid metabolism
ath00564 Glycerophospholipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
6254308 Acyl chain remodelling of PG
6254311 Acyl chain remodelling of PS

Domain Information

InterPro Annotations

Accession Description
IPR002123 Phospholipid/glycerol acyltransferase

UniProt Annotations

Entry Information

Gene Name
phospholipid/glycerol acyltransferase family protein
Protein Entry
LPCT1_ARATH
UniProt ID
Q8L7R3
Species
Arabidopsis

Comments

Comment Type Description
Biophysicochemical Properties pH dependence: Optimum pH is 6.0-9.0. {ECO:0000269|PubMed:19445718};
Catalytic Activity Acyl-CoA + 1-O-(alk-1-enyl)glycero-3- phosphocholine = CoA + plasmenylcholine. {ECO:0000269|PubMed:19445718}.
Domain The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphocholine. {ECO:0000250}.
Function Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates. Exhibits strong acylation activity of lysophosphatidylethanolamine (LPE) and lysophosphatidate (LPA), with lower activity on lysophosphatidylcholine (LPC) and lysophosphatidylserine (LPS). Has a preference for 18:1-LPE over 16:0-LPE as acceptor and palmitoyl-CoA (16:0-CoA) as acyl donor. Activity is calcium-independent. {ECO:0000269|PubMed:19445718}.
Pathway Lipid metabolism; phospholipid metabolism.
Sequence Caution Sequence=AAF14683.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000305|PubMed:16618929, ECO:0000305|PubMed:22923678}; Single-pass membrane protein {ECO:0000305|PubMed:16618929, ECO:0000305|PubMed:22923678}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010589 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18412918 RefSeq NP_565249 398 phospholipid/glycerol acyltransferase family protein

Identical Sequences to LMP010589 proteins

Reference Database Accession Length Protein Name
GI:18412918 GenBank AAM91515.1 398 unknown protein [Arabidopsis thaliana]
GI:18412918 GenBank AAO29964.1 398 unknown protein [Arabidopsis thaliana]
GI:18412918 GenBank AEE36471.1 398 phospholipid/glycerol acyltransferase family protein [Arabidopsis thaliana]
GI:18412918 SwissProt Q8L7R3.1 398 RecName: Full=Lysophospholipid acyltransferase LPEAT1; AltName: Full=Lysophosphatidylethanolamine acyltransferase 1; Short=AtLPEAT1 [Arabidopsis thaliana]

Related Sequences to LMP010589 proteins

Reference Database Accession Length Protein Name
GI:18412918 GenBank AAF14683.1 379 Is a member of the PF|01553 Acyltransferase family [Arabidopsis thaliana]
GI:18412918 GenBank AAM61059.1 398 unknown [Arabidopsis thaliana]
GI:18412918 GenBank EFH64061.1 396 hypothetical protein ARALYDRAFT_477149 [Arabidopsis lyrata subsp. lyrata]
GI:18412918 RefSeq XP_002887802.1 396 hypothetical protein ARALYDRAFT_477149 [Arabidopsis lyrata subsp. lyrata]
GI:18412918 RefSeq XP_010417643.1 396 PREDICTED: lysophospholipid acyltransferase LPEAT1 isoform X1 [Camelina sativa]
GI:18412918 RefSeq XP_010429877.1 396 PREDICTED: lysophospholipid acyltransferase LPEAT1-like isoform X1 [Camelina sativa]