Gene/Proteome Database (LMPD)

LMPD ID
LMP010590
Gene ID
819175
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
calcineurin B subunit-related protein
Gene Symbol
AT2G45670
Synonyms
F17K2.20
Alternate Names
calcineurin B subunit-related protein
Chromosome
2
EC Number
2.3.1.25

Proteins

calcineurin B subunit-related protein
Refseq ID NP_566052
Protein GI 18406856
UniProt ID Q8S8S2
mRNA ID NM_130130
Length 281
RefSeq Status REVIEWED
MADPDLSSPLIHHQSSDQPEVVISIADDDDDESGLNLLPAVVDPRVSRGFEFDHLNPYGFLSESEPPVLGPTTVDPFRNNTPGVSGLYEAIKLVICLPIALIRLVLFAASLAVGYLATKLALAGWKDKENPMPLWRCRIMWITRICTRCILFSFGYQWIRRKGKPARREIAPIVVSNHVSYIEPIFYFYELSPTIVASESHDSLPFVGTIIRAMQVIYVNRFSQTSRKNAVHEIKGCKYREKLPAIDFLVCCYSPKEPRLMGKFLFPSNSVLSSLVTLFNL
calcineurin B subunit-related protein
Refseq ID NP_566051
Protein GI 18406854
UniProt ID Q8S8S2
mRNA ID NM_130129
Length 539
RefSeq Status REVIEWED
MADPDLSSPLIHHQSSDQPEVVISIADDDDDESGLNLLPAVVDPRVSRGFEFDHLNPYGFLSESEPPVLGPTTVDPFRNNTPGVSGLYEAIKLVICLPIALIRLVLFAASLAVGYLATKLALAGWKDKENPMPLWRCRIMWITRICTRCILFSFGYQWIRRKGKPARREIAPIVVSNHVSYIEPIFYFYELSPTIVASESHDSLPFVGTIIRAMQVIYVNRFSQTSRKNAVHEIKRKASCDRFPRLLLFPEGTTTNGKVLISFQLGAFIPGYPIQPVVVRYPHVHFDQSWGNISLLTLMFRMFTQFHNFMEVEYLPVIYPSEKQKQNAVRLSQKTSHAIATSLNVVQTSHSFADLMLLNKATELKLENPSNYMVEMARVESLFHVSSLEATRFLDTFVSMIPDSSGRVRLHDFLRGLKLKPCPLSKRIFEFIDVEKVGSITFKQFLFASGHVLTQPLFKQTCELAFSHCDADGDGYITIQELGEALKNTIPNLNKDEIRGMYHLLDDDQDQRISQNDLLSCLRRNPLLIAIFAPDLAPT

Gene Information

Entrez Gene ID
819175
Gene Name
calcineurin B subunit-related protein
Gene Symbol
AT2G45670
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005509 IEA:InterPro F calcium ion binding
GO:0050200 IDA:UniProtKB F plasmalogen synthase activity
GO:0008654 IEA:UniProtKB-KW P phospholipid biosynthetic process
GO:0006644 IDA:UniProtKB P phospholipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ath00565 Ether lipid metabolism
ath00564 Glycerophospholipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
6254308 Acyl chain remodelling of PG
6254311 Acyl chain remodelling of PS

Domain Information

InterPro Annotations

Accession Description
IPR018247 EF-Hand 1, calcium-binding site
IPR002048 EF-hand domain
IPR011992 EF-hand domain pair
IPR002123 Phospholipid/glycerol acyltransferase

UniProt Annotations

Entry Information

Gene Name
calcineurin B subunit-related protein
Protein Entry
LPCT2_ARATH
UniProt ID
Q8S8S2
Species
Arabidopsis

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8S8S2-1; Sequence=Displayed; Name=2; IsoId=Q8S8S2-2; Sequence=VSP_046521, VSP_046522; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.;
Biophysicochemical Properties pH dependence: Optimum pH is 9.0. {ECO:0000269|PubMed:19445718};
Catalytic Activity Acyl-CoA + 1-O-(alk-1-enyl)glycero-3- phosphocholine = CoA + plasmenylcholine. {ECO:0000269|PubMed:19445718}.
Domain The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphocholine. {ECO:0000250}.
Function Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates. Exhibits strong acylation activity of lysophosphatidylethanolamine (LPE) and lower activity on lysophosphatidate (LPA). Has a preference for 18:1-LPE over 16:0- LPE as acceptor and palmitoyl-CoA (16:0-CoA) as acyl donor. Activity is calcium-independent. {ECO:0000269|PubMed:19445718}.
Miscellaneous The ratio of isoform 2/isoform 1 mRNA is increased about 15-fold in the nonsense mRNA reducing factor mutant upf3-1. {ECO:0000305|PubMed:16098107}.
Pathway Lipid metabolism; phospholipid metabolism.
Similarity Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. {ECO:0000305}.
Similarity Contains 3 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}.
Subcellular Location Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010590 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18406854 RefSeq NP_566051 539 calcineurin B subunit-related protein
18406856 RefSeq NP_566052 281 calcineurin B subunit-related protein

Identical Sequences to LMP010590 proteins

Reference Database Accession Length Protein Name
GI:18406856 DBBJ BAD44014.1 281 unknown protein [Arabidopsis thaliana]
GI:18406856 DBBJ BAD44182.1 281 unknown protein [Arabidopsis thaliana]
GI:18406854 DBBJ BAD44223.1 539 unknown protein [Arabidopsis thaliana]
GI:18406854 GenBank AAM14898.1 539 unknown protein; alternative splicing isoform [Arabidopsis thaliana]
GI:18406854 GenBank AEC10584.1 539 calcineurin B subunit-related protein [Arabidopsis thaliana]
GI:18406856 GenBank AEC10585.1 281 calcineurin B subunit-related protein [Arabidopsis thaliana]
GI:18406856 gnl TIGR 281 unknown protein; supported by cDNA: gi:14334849 alternative splicing isoform [Arabidopsis thaliana]
GI:18406854 SwissProt Q8S8S2.1 539 RecName: Full=Lysophospholipid acyltransferase LPEAT2; AltName: Full=Lysophosphatidylethanolamine acyltransferase 2; Short=AtLPEAT2 [Arabidopsis thaliana]

Related Sequences to LMP010590 proteins

Reference Database Accession Length Protein Name
GI:18406854 DBBJ BAC42554.1 539 unknown protein [Arabidopsis thaliana]
GI:18406854 DBBJ BAD43371.1 539 unknown protein [Arabidopsis thaliana]
GI:18406854 DBBJ BAD43419.1 539 unknown protein [Arabidopsis thaliana]
GI:18406854 DBBJ BAD43601.1 539 unknown protein [Arabidopsis thaliana]
GI:18406856 DBBJ BAD44367.1 278 unnamed protein product, partial [Arabidopsis thaliana]
GI:18406856 GenBank AAM14898.1 539 unknown protein; alternative splicing isoform [Arabidopsis thaliana]
GI:18406854 GenBank EFH58284.1 528 hypothetical protein ARALYDRAFT_483703 [Arabidopsis lyrata subsp. lyrata]
GI:18406856 RefSeq NP_566051.1 539 calcineurin B subunit-related protein [Arabidopsis thaliana]
GI:18406854 RefSeq XP_002882025.1 528 hypothetical protein ARALYDRAFT_483703 [Arabidopsis lyrata subsp. lyrata]
GI:18406856 RefSeq XP_010506538.1 286 PREDICTED: lysophospholipid acyltransferase LPEAT2-like isoform X2 [Camelina sativa]
GI:18406856 RefSeq XP_010508130.1 282 PREDICTED: lysophospholipid acyltransferase LPEAT2-like isoform X2 [Camelina sativa]
GI:18406856 RefSeq XP_010518190.1 286 PREDICTED: lysophospholipid acyltransferase LPEAT2 isoform X2 [Camelina sativa]