Gene/Proteome Database (LMPD)

LMPD ID
LMP010682
Gene ID
821241
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
non-specific phospholipase C5
Gene Symbol
NPC5
Synonyms
non-specific phospholipase C5; NPC5; T21P5.4
Alternate Names
non-specific phospholipase C5
Chromosome
3
EC Number
3.1.4.3
Summary
Encodes a nonspecific phospholipase C. Located in the cytosol. Involved in the conversion of phospholipids to glycolipids under phosphate deprivation conditions.
Orthologs
View orthologs and multiple alignments for NPC5

Proteins

non-specific phospholipase C5
Refseq ID NP_566207
Protein GI 18396579
UniProt ID Q9S816
mRNA ID NM_111225
Length 521
RefSeq Status REVIEWED
MAETKKGSESYPIKTIVVLVQENRSFDHTLGWFKELNREIDGVMKSDQKFNPGFSSDLNSHNVVFGDQSQYVDPNPGHSIRDIYEQVFGKPWDSGHPDPNPGPATMSGFAQNAERKMKGMSSAVMNGFKPDALPVYKELVQNFAICDRWFASVPGATQPNRLFIHSATSHGTTNNERKLLIEGFPQKTIFESLDEAGFTFGIYYQCFPTTLFYRNLRKLKYLTRFHDYGLQFKKDCKEGNLPNYVVVEQRWYDLLLNPANDDHPSHDVSEGQKLVKEVYEALRSSPQWNEILFIITYDEHGGFYDHVPTPLDGVPNPDGILGPPPYNFEFNRLGVRVPTFFISPWIEPGTVLHGSNGPYLMSQYEHSSIPATVKKIFKLKDFLTKRDSWAGTFESVITRNSPRQDCPETLSNPVKMRGTVAKENAELSDFQEELVIVAAGLKGDYKNEELLYKLCKKTCVSDASKYVTKAFDKFVEESKKARERGGDENDIVFCVDDDDDHNVVKPPPSQSEPSHATPWSN

Gene Information

Entrez Gene ID
821241
Gene Name
non-specific phospholipase C5
Gene Symbol
NPC5
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:TAIR C cytosol
GO:0034480 IEA:UniProtKB-EC F phosphatidylcholine phospholipase C activity
GO:0004629 IDA:TAIR F phospholipase C activity
GO:0016036 IMP:TAIR P cellular response to phosphate starvation
GO:0009247 IMP:TAIR P glycolipid biosynthetic process
GO:0009395 IMP:TAIR P phospholipid catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ath00565 Ether lipid metabolism
ath00564 Glycerophospholipid metabolism
ath00562 Inositol phosphate metabolism
ath01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR017850 Alkaline-phosphatase-like, core domain
IPR007312 Phosphoesterase

UniProt Annotations

Entry Information

Gene Name
non-specific phospholipase C5
Protein Entry
NPC5_ARATH
UniProt ID
Q9S816
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity A phosphatidylcholine + H(2)O = 1,2-diacyl-sn- glycerol + phosphocholine.
Disruption Phenotype No visible phenotype under normal growth conditions, but mutant plants accumulates reduced levels of digalactosyldiacylglycerol (DGDG) during phosphate limitation. {ECO:0000269|PubMed:18564386}.
Function Non-specific phospholipase C (PLC) which assumes minor PLC activity during inorganic phosphate starvation. Can hydrolyze both phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Required for normal accumulation of digalactosyldiacylglycerol (DGDG) during phosphate limitation and may contribute to the conversion of phospholipids to diacylglycerol, the substrate for galactolipid synthesis. {ECO:0000269|PubMed:18564386}.
Induction Slightly induced by inorganic phosphate deprivation. {ECO:0000269|PubMed:15618226, ECO:0000269|PubMed:18564386}.
Similarity Belongs to the bacterial phospholipase C family. {ECO:0000305}.
Subcellular Location Cytoplasm, cytosol {ECO:0000269|PubMed:18564386}.
Tissue Specificity Specifically expressed in flowers. {ECO:0000269|PubMed:20507939}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010682 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18396579 RefSeq NP_566207 521 non-specific phospholipase C5

Identical Sequences to LMP010682 proteins

Reference Database Accession Length Protein Name
GI:18396579 DBBJ BAC22509.1 521 phosphatidylglycerol specific phospholipase C [Arabidopsis thaliana]
GI:18396579 GenBank AAF01581.1 521 unknown protein [Arabidopsis thaliana]
GI:18396579 GenBank AAF03477.1 521 putative phospholipase [Arabidopsis thaliana]
GI:18396579 GenBank AEE73955.1 521 non-specific phospholipase C5 [Arabidopsis thaliana]
GI:18396579 SwissProt Q9S816.1 521 RecName: Full=Non-specific phospholipase C5 [Arabidopsis thaliana]

Related Sequences to LMP010682 proteins

Reference Database Accession Length Protein Name
GI:18396579 GenBank EFH60651.1 523 phosphoesterase family protein [Arabidopsis lyrata subsp. lyrata]
GI:18396579 GenBank EOA32033.1 512 hypothetical protein CARUB_v10015277mg [Capsella rubella]
GI:18396579 GenBank ESQ49746.1 541 hypothetical protein EUTSA_v10020472mg [Eutrema salsugineum]
GI:18396579 RefSeq XP_002884392.1 523 phosphoesterase family protein [Arabidopsis lyrata subsp. lyrata]
GI:18396579 RefSeq XP_006299135.1 512 hypothetical protein CARUB_v10015277mg [Capsella rubella]
GI:18396579 RefSeq XP_010485694.1 514 PREDICTED: non-specific phospholipase C5 [Camelina sativa]