Gene/Proteome Database (LMPD)
LMPD ID
LMP010709
Gene ID
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
omega-6 fatty acid desaturase
Gene Symbol
Synonyms
CHLOROPLAST PRECURSOR; F6I18.140; F6I18_140; FAD6; FADC; fatty acid desaturase 6; FATTY ACID DESATURASE C; OMEGA-6 FATTY ACID DESATURASE; SFD4; STEAROYL DESATURASE DEFICIENCY 4
Alternate Names
omega-6 fatty acid desaturase
Chromosome
4
EC Number
1.14.19.-
Summary
Chloroplastic enzyme responsible for the synthesis of 16:2 and 18:2 fatty acids from galactolipids, sulpholipids and phosphatidylglycerol. Uses ferredoxin as electron donor. Gene mutation resulted in reduced level of unsaturated fatty acids leading to susceptibility to photoinhibition.
Orthologs
Proteins
| omega-6 fatty acid desaturase | |
|---|---|
| Refseq ID | NP_194824 |
| Protein GI | 15235766 |
| UniProt ID | P46312 |
| mRNA ID | NM_119243 |
| Length | 448 |
| RefSeq Status | REVIEWED |
| MASRIADSLFAFTGPQQCLPRVPKLAASSARVSPGVYAVKPIDLLLKGRTHRSRRCVAPVKRRIGCIKAVAAPVAPPSADSAEDREQLAESYGFRQIGEDLPENVTLKDIMDTLPKEVFEIDDLKALKSVLISVTSYTLGLFMIAKSPWYLLPLAWAWTGTAITGFFVIGHDCAHKSFSKNKLVEDIVGTLAFLPLVYPYEPWRFKHDRHHAKTNMLVHDTAWQPVPPEEFESSPVMRKAIIFGYGPIRPWLSIAHWVNWHFNLKKFRASEVNRVKISLACVFAFMAVGWPLIVYKVGILGWVKFWLMPWLGYHFWMSTFTMVHHTAPHIPFKPADEWNAAQAQLNGTVHCDYPSWIEILCHDINVHIPHHISPRIPSYNLRAAHESIQENWGKYTNLATWNWRLMKTIMTVCHVYDKEENYIPFDRLAPEESQPITFLKKAMPNYTA | |
Gene Information
Entrez Gene ID
Gene Name
omega-6 fatty acid desaturase
Gene Symbol
Species
Arabidopsis thaliana
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0009507 | IDA:TAIR | C | chloroplast |
| GO:0009941 | IDA:TAIR | C | chloroplast envelope |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0009528 | IEA:UniProtKB-KW | C | plastid inner membrane |
| GO:0016491 | IEA:UniProtKB-KW | F | oxidoreductase activity |
| GO:0006633 | TAS:TAIR | P | fatty acid biosynthetic process |
| GO:0010205 | IMP:TAIR | P | photoinhibition |
| GO:0006636 | IEA:UniProtKB-UniPathway | P | unsaturated fatty acid biosynthetic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ath01040 | Biosynthesis of unsaturated fatty acids |
| ath01212 | Fatty acid metabolism |
BIOCYC Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR005804 | Fatty acid desaturase, type 1 |
UniProt Annotations
Entry Information
Gene Name
omega-6 fatty acid desaturase
Protein Entry
FAD6C_ARATH
UniProt ID
Species
Arabidopsis
Comments
| Comment Type | Description |
|---|---|
| Developmental Stage | Highest levels found in expanding leaves. |
| Domain | The histidine box domains may contain the active site and/or be involved in metal ion binding. |
| Function | Chloroplast omega-6 fatty acid desaturase introduces the second double bond in the biosynthesis of 16:3 and 18:3 fatty acids, important constituents of plant membranes. It is thought to use ferredoxin as an electron donor and to act on fatty acids esterified to galactolipids, sulfolipids and phosphatidylglycerol. |
| Pathway | Lipid metabolism; polyunsaturated fatty acid biosynthesis. |
| Similarity | Belongs to the fatty acid desaturase family. {ECO:0000305}. |
| Subcellular Location | Plastid, chloroplast inner membrane {ECO:0000269|PubMed:12766230}; Multi-pass membrane protein {ECO:0000269|PubMed:12766230}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP010709 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 15235766 | RefSeq | NP_194824 | 448 | omega-6 fatty acid desaturase |
Identical Sequences to LMP010709 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:15235766 | GenBank | AAK73979.1 | 448 | AT4g30950/F6I18_140 [Arabidopsis thaliana] |
| GI:15235766 | GenBank | AAL24186.1 | 448 | AT4g30950/F6I18_140 [Arabidopsis thaliana] |
| GI:15235766 | GenBank | AAL24240.1 | 448 | AT4g30950/F6I18_140 [Arabidopsis thaliana] |
| GI:15235766 | GenBank | AAL79589.1 | 448 | AT4g30950/F6I18_140 [Arabidopsis thaliana] |
| GI:15235766 | GenBank | AAM65548.1 | 448 | chloroplast omega-6 fatty acid desaturase (fad6) [Arabidopsis thaliana] |
| GI:15235766 | GenBank | AEE85834.1 | 448 | omega-6 fatty acid desaturase [Arabidopsis thaliana] |
Related Sequences to LMP010709 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:15235766 | GenBank | ABI73993.1 | 447 | omega-6 fatty acid desaturase [Descurainia sophia] |
| GI:15235766 | GenBank | ABS86963.1 | 447 | chloroplast delta-12 fatty acid desaturase [Descurainia sophia] |
| GI:15235766 | GenBank | EFH43578.1 | 447 | omega-6 fatty acid desaturase [Arabidopsis lyrata subsp. lyrata] |
| GI:15235766 | RefSeq | XP_002867319.1 | 447 | omega-6 fatty acid desaturase [Arabidopsis lyrata subsp. lyrata] |
| GI:15235766 | RefSeq | XP_010432921.1 | 445 | PREDICTED: omega-6 fatty acid desaturase, chloroplastic isoform X1 [Camelina sativa] |
| GI:15235766 | RefSeq | XP_010432922.1 | 445 | PREDICTED: omega-6 fatty acid desaturase, chloroplastic isoform X2 [Camelina sativa] |