Gene/Proteome Database (LMPD)

LMPD ID
LMP010730
Gene ID
835527
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
PAP-specific phosphatase HAL2-like protein
Gene Symbol
HL
Synonyms
AHL; ATAHL; F24B18.1; F24B18_1; HAL2-like; HL
Alternate Names
PAP-specific phosphatase HAL2-like protein
Chromosome
5
EC Number
3.1.3.7

Proteins

PAP-specific phosphatase HAL2-like protein
Refseq ID NP_200250
Protein GI 15239631
UniProt ID Q38945
mRNA ID NM_124819
Length 373
RefSeq Status REVIEWED
MAVDSLETEIDTAVRVVHLASSLCVKVQEKLHLPNGGHVKSKDDDSPVTVADFGVQAIVSWVLAEVFGDQNLSIVAEEDTETLSEADSLGLLGAVSNAVNEALSEAQNYGLPKPVKPLGSSEILKAISRCNSVGGPKGRHWVLDPVDGTLGFVRGDQYAVALALIENGKVLLGVLGCPNYPVKKECLSNGCNQAMKTKAVAGSVSKGCVMYAKRGSGQAWMQPLIVGGIPESATLLKVSSVDDPVLATVCEPVERANSNHLFTAGLANSMGVRKQPMRVYSMVKYAAIARGDAEVFMKFAQSSYKEKIWDHAAGVVIVEEAGGVVTDAGGRNLDFSKGVYLEGLDRGIIACSGQVLHEKIIGAVYASWESSSL

Gene Information

Entrez Gene ID
835527
Gene Name
PAP-specific phosphatase HAL2-like protein
Gene Symbol
HL
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0008441 IDA:TAIR F 3'(2'),5'-bisphosphate nucleotidase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0016311 IDA:GOC P dephosphorylation
GO:0046854 IEA:InterPro P phosphatidylinositol phosphorylation
GO:0006790 IEA:InterPro P sulfur compound metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ath01100 Metabolic pathways
ath00920 Sulfur metabolism
ko00920 Sulfur metabolism

Domain Information

InterPro Annotations

Accession Description
IPR006239 3(2),5 -bisphosphate nucleotidase HAL2
IPR020550 Inositol monophosphatase, conserved site
IPR020583 Inositol monophosphatase, metal-binding site
IPR000760 Inositol_monophosphatase

UniProt Annotations

Entry Information

Gene Name
PAP-specific phosphatase HAL2-like protein
Protein Entry
DPNPH_ARATH
UniProt ID
Q38945
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity Adenosine 3',5'-bisphosphate + H(2)O = adenosine 5'-phosphate + phosphate.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Enzyme Regulation Inhibited by Li(+) (IC(50)=10 millimolar), Na(+) (IC(50)=50 millimolar) and Ca(2+) (IC(50)=0.06 millimolar).
Function Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. May regulate the flux of sulfur in the sulfur-activation pathway by converting PAPS to APS (By similarity). Prevents both the toxicity of PAP on RNA processing enzymes as well as the product inhibition by PAP of sulfate conjugation. {ECO:0000250, ECO:0000269|PubMed:10205895}.
Miscellaneous Substrate preference is 3'-phosphoadenosine 5'- phosphate (PAP) > adenosine 3'-phosphate 5'-phosphosulfate (PAPS). No activity observed against 3' or 5'-AMP, inositol mono and diphosphates and fructose-1,6-bisphosphate.
Similarity Belongs to the inositol monophosphatase family. {ECO:0000305}.
Tissue Specificity Expressed in roots, leaves, stems, flowers and siliques.

Identical and Related Proteins

Unique RefSeq proteins for LMP010730 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15239631 RefSeq NP_200250 373 PAP-specific phosphatase HAL2-like protein

Identical Sequences to LMP010730 proteins

Reference Database Accession Length Protein Name
GI:15239631 DBBJ BAA97512.1 373 3'(2'), 5'-bisphosphate nucleotidase protein-like protein [Arabidopsis thaliana]
GI:15239631 GenBank AAK76522.1 373 unknown protein [Arabidopsis thaliana]
GI:15239631 GenBank AAM14316.1 373 unknown protein [Arabidopsis thaliana]
GI:15239631 GenBank AAM63490.1 373 PAP-specific phosphatase [Arabidopsis thaliana]
GI:15239631 gnl TAIR 373 PAP-specific phosphatase HAL2-like protein [Arabidopsis thaliana]
GI:15239631 SwissProt Q38945.1 373 RecName: Full=PAP-specific phosphatase HAL2-like; AltName: Full=3'(2'),5'-bisphosphate nucleotidase; AltName: Full=3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase; AltName: Full=DPNPase; AltName: Full=Halotolerance protein [Arabidopsis thaliana]

Related Sequences to LMP010730 proteins

Reference Database Accession Length Protein Name
GI:15239631 GenBank AAB94051.1 373 PAP-specific phosphatase [Arabidopsis thaliana]
GI:15239631 GenBank EFH40587.1 373 hypothetical protein ARALYDRAFT_495519 [Arabidopsis lyrata subsp. lyrata]
GI:15239631 RefSeq XP_002864328.1 373 hypothetical protein ARALYDRAFT_495519 [Arabidopsis lyrata subsp. lyrata]
GI:15239631 RefSeq XP_010446867.1 373 PREDICTED: PAP-specific phosphatase HAL2-like [Camelina sativa]
GI:15239631 RefSeq XP_010482847.1 373 PREDICTED: PAP-specific phosphatase HAL2-like [Camelina sativa]
GI:15239631 RefSeq XP_010482848.1 373 PREDICTED: PAP-specific phosphatase HAL2-like [Camelina sativa]