Gene/Proteome Database (LMPD)
LMPD ID
LMP010763
Gene ID
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
peroxin-16
Gene Symbol
Synonyms
ARABIDOPSIS PEROXIN 16; ATPEX16; F17K2.22; PEROXIN 16; PEX16; SHRUNKEN SEED 1; SSE; SSE1
Alternate Names
peroxin-16
Chromosome
2
Summary
Encodes a protein with similarity to yeast Pep.6, a membrane localized protein involved in peroxisome assembly and protein-trafficking. SSE1 mutant seeds do not accumulate oils and dessicated seeds have a shrunken appearance. Involved in protein and oil body biogenesis. SSE is expressed during seed development, reaching the highest peak in mature siliques. Expression in leaves and roots is low compared to cotyledons and flowers. Located in peroxisomes and endoplasmic reticulum. Homologous to the peroxin PEX16 and complements the pex16 mutants of the yeast Yarrowia lipolytica.
Orthologs
Proteins
| peroxin-16 | |
|---|---|
| Refseq ID | NP_566053 |
| Protein GI | 18406863 |
| UniProt ID | Q8S8S1 |
| mRNA ID | NM_130132 |
| Length | 367 |
| RefSeq Status | REVIEWED |
| MEAYKQWVWRNREYVQSFGSFANGLTWLLPEKFSASEIGPEAVTAFLGIFSTINEHIIENAPTPRGHVGSSGNDPSLSYPLLIAILKDLETVVEVAAEHFYGDKKWNYIILTEAMKAVIRLALFRNSGYKMLLQGGETPNEEKDSNQSESQNRAGNSGRNLGPHGLGNQNHHNPWNLEGRAMSALSSFGQNARTTTSSTPGWSRRIQHQQAVIEPPMIKERRRTMSELLTEKGVNGALFAIGEVLYITRPLIYVLFIRKYGVRSWIPWAISLSVDTLGMGLLANSKWWGEKSKQVHFSGPEKDELRRRKLIWALYLMRDPFFTKYTRQKLESSQKKLELIPLIGFLTEKIVELLEGAQSRYTYISGS | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005789 | IDA:TAIR | C | endoplasmic reticulum membrane |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005777 | IDA:TAIR | C | peroxisome |
| GO:0006633 | IMP:TAIR | P | fatty acid biosynthetic process |
| GO:0007031 | IMP:TAIR | P | peroxisome organization |
KEGG Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR013919 | Peroxisome membrane protein, Pex16 |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Developmental Stage | Up-regulated during seed maturation. {ECO:0000269|PubMed:10195899}. |
| Disruption Phenotype | Not viable shrunken seeds. Starch accumulation in mature embryos, cotyledon and hypocotyl cells. Developmental delay during early embryo morphogenesis. {ECO:0000269|PubMed:10195899}. |
| Domain | The internal domain (235-279) containing two internal membrane helices and the intervening residues that include the basic cluster VRS is sufficient for targeting recombinant proteins to endoplasmic reticulum and then to peroxisomes. |
| Function | Involved in the formation of peroxisomes, lipid bodies and protein bodies. {ECO:0000269|PubMed:10195899, ECO:0000269|PubMed:15173561, ECO:0000269|PubMed:16896794, ECO:0000269|PubMed:17431024, ECO:0000269|PubMed:17478547}. |
| Miscellaneous | Travels from the cytosol to peroxisomes via the reticular and perinuclear endoplasmic reticulum (ER) and an ER- peroxisome intermediate compartment (ERPIC). |
| Ptm | The detection of an additional immunorelated polypeptide of 52 kDa suggests a post-translational modification of PEX16. |
| Similarity | Belongs to the peroxin-16 family. {ECO:0000305}. |
| Subcellular Location | Peroxisome membrane {ECO:0000305}; Multi- pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Moves through an intermediate compartment from endoplasmic reticulum to pre-existing peroxisomes. {ECO:0000269|PubMed:15173561, ECO:0000269|PubMed:16040658, ECO:0000269|PubMed:17431024}. |
| Tissue Specificity | Expressed in roots, siliques, seeds, cotyledons, leaves and flowers. Low expression in leaves and roots. {ECO:0000269|PubMed:10195899, ECO:0000269|PubMed:15173561, ECO:0000269|PubMed:16040658}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP010763 (as displayed in Record Overview)
Identical Sequences to LMP010763 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:18406863 | DBBJ | BAD43159.1 | 367 | shrunken seed protein (SSE1) [Arabidopsis thaliana] |
| GI:18406863 | GenBank | AAM14899.1 | 367 | expressed protein [Arabidopsis thaliana] |
| GI:18406863 | GenBank | AEC10587.1 | 367 | peroxin-16 [Arabidopsis thaliana] |
| GI:18406863 | SwissProt | Q8S8S1.1 | 367 | RecName: Full=Peroxisome biogenesis protein 16; AltName: Full=Peroxin-16; Short=AtPEX16; Short=AtPex16p; AltName: Full=Protein SHRUNKEN SEED 1 [Arabidopsis thaliana] |
Related Sequences to LMP010763 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:18406863 | DBBJ | BAD43177.1 | 367 | shrunken seed protein (SSE1) [Arabidopsis thaliana] |
| GI:18406863 | GenBank | AAD30661.1 | 367 | shrunken seed protein [Arabidopsis thaliana] |
| GI:18406863 | GenBank | AAX01914.1 | 367 | Sequence 2 from patent US 6841722 |
| GI:18406863 | GenBank | EFH58286.1 | 368 | hypothetical protein ARALYDRAFT_483706 [Arabidopsis lyrata subsp. lyrata] |
| GI:18406863 | PIR | - | 360 | hypothetical protein At2g45690 [imported] - Arabidopsis thaliana [Arabidopsis thaliana] |
| GI:18406863 | RefSeq | XP_002882027.1 | 368 | hypothetical protein ARALYDRAFT_483706 [Arabidopsis lyrata subsp. lyrata] |