Gene/Proteome Database (LMPD)

LMPD ID
LMP010778
Gene ID
820113
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
phosphatidic acid phosphohydrolase 1
Gene Symbol
AT3G09560
Synonyms
ATPAH1; PAH1; PHOSPHATIDIC ACID PHOSPHOHYDROLASE 1
Alternate Names
phosphatidic acid phosphohydrolase 1
Chromosome
3
EC Number
3.1.3.4

Proteins

phosphatidic acid phosphohydrolase 1
Refseq ID NP_001118604
Protein GI 186509922
UniProt ID Q9SF47
mRNA ID NM_001125132
Length 904
RefSeq Status REVIEWED
MSLVGRVGSLISQGVYSVATPFHPFGGAIDVIVVQQQDGSFRSTPWYVRFGKFQGVLKGAEKFVRISVNGTEADFHMYLDNSGEAYFIREVDPAANDTNNLISGSENNNGNQNNGVTYRLEHSLSDSGTGELREGFDPLSRLERTESDCNRRFYDFQDDPPSPTSEYGSARFDNLNVESYGDSQGSDSEVVLVSIDGHILTAPVSVAEQEAENLRLNTPQFHLAPGDGTEFCEGNTEFASSETPWDTEYIDKVEESSDTANIASDKVDAINDERNDLDSHSRDNAEKDSHDAERDLLGSCLEQSELTKTSENVKSEEPGPTFEDRNLKEGEFPLRTIMENDRSEDEVTIESIDTLVDSFESSTTQITIEEVKTTEGSRISVDSNADSECKDEQTSAETAILFNNQESSISVDSNADSECKDEQPRISAETAILINNQEGGIIESEDQDSERVSIDSTREEVDKDNEDRKTVVSVGVTSSVDEGEPDTDQRYELSLCKDELRQGMGLSAAAEVFDAHMISKEEYINSATSILESENLVVRIRETYMPWTKAARIVLGKAVFDLDLDIQPDDVISVEENESPKPKDDETTITPSSSGTRWRLWPIPFRRVKTVEHTGSNSSSEEDLFVDSEPGLQNSPETQSTTESRHESPRRQLVRTNVPTNEQIASLNLKDGQNMITFSFSTRVLGTQQVDAHIYRWRWDTKIVISDVDGTITKSDVLGQFMPFIGKDWTQSGVAKLFSAIKENGYQLLFLSARAIVQAYLTRNFLNNLKQDGKALPTGPVVISPDGLFPALYREVIRRAPHEFKIACLEDIRKLFPTDYNPFYAGFGNRDTDELSYRKLGIPKGKIFIINPKGEVATGHRIDVKKSYTSLHTLVNDMFPPTSLVEQEDYNPWNFWKLPIEEVE
phosphatidic acid phosphohydrolase 1
Refseq ID NP_187567
Protein GI 15232716
UniProt ID Q9SF47
mRNA ID NM_111790
Length 904
RefSeq Status REVIEWED
Protein sequence is identical to GI:186509922 (mRNA isoform)
phosphatidic acid phosphohydrolase 1
Refseq ID NP_974268
Protein GI 42572345
UniProt ID Q9SF47
mRNA ID NM_202539
Length 904
RefSeq Status REVIEWED
Protein sequence is identical to GI:186509922 (mRNA isoform)

Gene Information

Entrez Gene ID
820113
Gene Name
phosphatidic acid phosphohydrolase 1
Gene Symbol
AT3G09560
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0000139 IDA:UniProtKB C Golgi membrane
GO:0032586 IDA:UniProtKB C protein storage vacuole membrane
GO:0008195 IGI:TAIR F phosphatidate phosphatase activity
GO:0016036 IGI:TAIR P cellular response to phosphate starvation
GO:0016311 IGI:GOC P dephosphorylation
GO:0006886 IDA:UniProtKB P intracellular protein transport
GO:0006629 IGI:TAIR P lipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ath00561 Glycerolipid metabolism
ath00564 Glycerophospholipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
6254420 Depolymerisation of the Nuclear Lamina
6254221 Synthesis of PC

Domain Information

InterPro Annotations

Accession Description
IPR023214 HAD-like domain
IPR013209 LNS2, Lipin/Ned1/Smp2
IPR007651 Lipin, N-terminal

UniProt Annotations

Entry Information

Gene Name
phosphatidic acid phosphohydrolase 1
Protein Entry
PAH1_ARATH
UniProt ID
Q9SF47
Species
Arabidopsis

Comments

Comment Type Description
Biophysicochemical Properties pH dependence: Optimum pH is 6.5. {ECO:0000269|PubMed:20699392};
Catalytic Activity A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:19923426, ECO:0000269|PubMed:20699392};
Disruption Phenotype No visible phenotype under normal growth conditions, but the double mutants pah1 and pah2-1 show reduced growth. {ECO:0000269|PubMed:19923426, ECO:0000269|PubMed:20699392}.
Domain Contains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif essential for phosphatidate phosphatase activity.
Function Magnesium-dependent phosphatidate phosphatase which catalyzes the dephosphorylation of phosphatidate to yield diacylglycerol. Acts redundantly with PAH2 to repress phospholipid biosynthesis at the endoplasmic reticulum (ER). May function indirectly as repressor of multiple enzymes involved in phospholipid biosynthesis. Is involved in the pathway of galactolipid synthesis in the ER, which is required for the membrane lipid remodeling, an essential adaptation mechanism to cope with phosphate starvation. {ECO:0000269|PubMed:19923426, ECO:0000269|PubMed:20699392, ECO:0000269|PubMed:21205207}.
Sequence Caution Sequence=ACT37431.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
Similarity Belongs to the lipin family. {ECO:0000305}.
Subcellular Location Cytoplasm, cytosol.
Tissue Specificity Expressed in roots, leaves, stems, flowers, siliques, embryos and mature seeds. {ECO:0000269|PubMed:20699392, ECO:0000269|PubMed:21205207}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010778 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
186509922 RefSeq NP_001118604 904 phosphatidic acid phosphohydrolase 1

Identical Sequences to LMP010778 proteins

Reference Database Accession Length Protein Name
GI:186509922 GenBank AEE74780.1 904 lipin-like protein [Arabidopsis thaliana]
GI:186509922 GenBank AEE74781.1 904 lipin-like protein [Arabidopsis thaliana]
GI:186509922 GenBank AEE74782.1 904 lipin-like protein [Arabidopsis thaliana]
GI:186509922 RefSeq NP_187567.1 904 phosphatidic acid phosphohydrolase 1 [Arabidopsis thaliana]
GI:186509922 RefSeq NP_974268.1 904 phosphatidic acid phosphohydrolase 1 [Arabidopsis thaliana]
GI:186509922 SwissProt Q9SF47.1 904 RecName: Full=Phosphatidate phosphatase PAH1; AltName: Full=Phosphatidic acid phosphohydrolase 1; Short=AtPAH1 [Arabidopsis thaliana]

Related Sequences to LMP010778 proteins

Reference Database Accession Length Protein Name
GI:186509922 DBBJ BAF01347.1 904 hypothetical protein [Arabidopsis thaliana]
GI:186509922 GenBank ACT37431.1 913 type-1 phosphatidic acid phosphohydrolase 1 [Arabidopsis thaliana]
GI:186509922 GenBank EFH61000.1 875 lipin family protein [Arabidopsis lyrata subsp. lyrata]
GI:186509922 RefSeq XP_002884741.1 875 lipin family protein [Arabidopsis lyrata subsp. lyrata]
GI:186509922 RefSeq XP_010474064.1 885 PREDICTED: phosphatidate phosphatase PAH1 [Camelina sativa]
GI:186509922 RefSeq XP_010486529.1 885 PREDICTED: phosphatidate phosphatase PAH1-like [Camelina sativa]