Gene/Proteome Database (LMPD)
Proteins
| phosphatidic acid phosphohydrolase 1 | |
|---|---|
| Refseq ID | NP_001118604 |
| Protein GI | 186509922 |
| UniProt ID | Q9SF47 |
| mRNA ID | NM_001125132 |
| Length | 904 |
| RefSeq Status | REVIEWED |
| MSLVGRVGSLISQGVYSVATPFHPFGGAIDVIVVQQQDGSFRSTPWYVRFGKFQGVLKGAEKFVRISVNGTEADFHMYLDNSGEAYFIREVDPAANDTNNLISGSENNNGNQNNGVTYRLEHSLSDSGTGELREGFDPLSRLERTESDCNRRFYDFQDDPPSPTSEYGSARFDNLNVESYGDSQGSDSEVVLVSIDGHILTAPVSVAEQEAENLRLNTPQFHLAPGDGTEFCEGNTEFASSETPWDTEYIDKVEESSDTANIASDKVDAINDERNDLDSHSRDNAEKDSHDAERDLLGSCLEQSELTKTSENVKSEEPGPTFEDRNLKEGEFPLRTIMENDRSEDEVTIESIDTLVDSFESSTTQITIEEVKTTEGSRISVDSNADSECKDEQTSAETAILFNNQESSISVDSNADSECKDEQPRISAETAILINNQEGGIIESEDQDSERVSIDSTREEVDKDNEDRKTVVSVGVTSSVDEGEPDTDQRYELSLCKDELRQGMGLSAAAEVFDAHMISKEEYINSATSILESENLVVRIRETYMPWTKAARIVLGKAVFDLDLDIQPDDVISVEENESPKPKDDETTITPSSSGTRWRLWPIPFRRVKTVEHTGSNSSSEEDLFVDSEPGLQNSPETQSTTESRHESPRRQLVRTNVPTNEQIASLNLKDGQNMITFSFSTRVLGTQQVDAHIYRWRWDTKIVISDVDGTITKSDVLGQFMPFIGKDWTQSGVAKLFSAIKENGYQLLFLSARAIVQAYLTRNFLNNLKQDGKALPTGPVVISPDGLFPALYREVIRRAPHEFKIACLEDIRKLFPTDYNPFYAGFGNRDTDELSYRKLGIPKGKIFIINPKGEVATGHRIDVKKSYTSLHTLVNDMFPPTSLVEQEDYNPWNFWKLPIEEVE | |
Gene Information
Entrez Gene ID
Gene Name
phosphatidic acid phosphohydrolase 1
Gene Symbol
Species
Arabidopsis thaliana
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0000139 | IDA:UniProtKB | C | Golgi membrane |
| GO:0032586 | IDA:UniProtKB | C | protein storage vacuole membrane |
| GO:0008195 | IGI:TAIR | F | phosphatidate phosphatase activity |
| GO:0016036 | IGI:TAIR | P | cellular response to phosphate starvation |
| GO:0016311 | IGI:GOC | P | dephosphorylation |
| GO:0006886 | IDA:UniProtKB | P | intracellular protein transport |
| GO:0006629 | IGI:TAIR | P | lipid metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ath00561 | Glycerolipid metabolism |
| ath00564 | Glycerophospholipid metabolism |
REACTOME Pathway Links
Domain Information
UniProt Annotations
Entry Information
Gene Name
phosphatidic acid phosphohydrolase 1
Protein Entry
PAH1_ARATH
UniProt ID
Species
Arabidopsis
Comments
| Comment Type | Description |
|---|---|
| Biophysicochemical Properties | pH dependence: Optimum pH is 6.5. {ECO:0000269|PubMed:20699392}; |
| Catalytic Activity | A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate. |
| Cofactor | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:19923426, ECO:0000269|PubMed:20699392}; |
| Disruption Phenotype | No visible phenotype under normal growth conditions, but the double mutants pah1 and pah2-1 show reduced growth. {ECO:0000269|PubMed:19923426, ECO:0000269|PubMed:20699392}. |
| Domain | Contains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif essential for phosphatidate phosphatase activity. |
| Function | Magnesium-dependent phosphatidate phosphatase which catalyzes the dephosphorylation of phosphatidate to yield diacylglycerol. Acts redundantly with PAH2 to repress phospholipid biosynthesis at the endoplasmic reticulum (ER). May function indirectly as repressor of multiple enzymes involved in phospholipid biosynthesis. Is involved in the pathway of galactolipid synthesis in the ER, which is required for the membrane lipid remodeling, an essential adaptation mechanism to cope with phosphate starvation. {ECO:0000269|PubMed:19923426, ECO:0000269|PubMed:20699392, ECO:0000269|PubMed:21205207}. |
| Sequence Caution | Sequence=ACT37431.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305}; |
| Similarity | Belongs to the lipin family. {ECO:0000305}. |
| Subcellular Location | Cytoplasm, cytosol. |
| Tissue Specificity | Expressed in roots, leaves, stems, flowers, siliques, embryos and mature seeds. {ECO:0000269|PubMed:20699392, ECO:0000269|PubMed:21205207}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP010778 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 186509922 | RefSeq | NP_001118604 | 904 | phosphatidic acid phosphohydrolase 1 |
Identical Sequences to LMP010778 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:186509922 | GenBank | AEE74780.1 | 904 | lipin-like protein [Arabidopsis thaliana] |
| GI:186509922 | GenBank | AEE74781.1 | 904 | lipin-like protein [Arabidopsis thaliana] |
| GI:186509922 | GenBank | AEE74782.1 | 904 | lipin-like protein [Arabidopsis thaliana] |
| GI:186509922 | RefSeq | NP_187567.1 | 904 | phosphatidic acid phosphohydrolase 1 [Arabidopsis thaliana] |
| GI:186509922 | RefSeq | NP_974268.1 | 904 | phosphatidic acid phosphohydrolase 1 [Arabidopsis thaliana] |
| GI:186509922 | SwissProt | Q9SF47.1 | 904 | RecName: Full=Phosphatidate phosphatase PAH1; AltName: Full=Phosphatidic acid phosphohydrolase 1; Short=AtPAH1 [Arabidopsis thaliana] |
Related Sequences to LMP010778 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:186509922 | DBBJ | BAF01347.1 | 904 | hypothetical protein [Arabidopsis thaliana] |
| GI:186509922 | GenBank | ACT37431.1 | 913 | type-1 phosphatidic acid phosphohydrolase 1 [Arabidopsis thaliana] |
| GI:186509922 | GenBank | EFH61000.1 | 875 | lipin family protein [Arabidopsis lyrata subsp. lyrata] |
| GI:186509922 | RefSeq | XP_002884741.1 | 875 | lipin family protein [Arabidopsis lyrata subsp. lyrata] |
| GI:186509922 | RefSeq | XP_010474064.1 | 885 | PREDICTED: phosphatidate phosphatase PAH1 [Camelina sativa] |
| GI:186509922 | RefSeq | XP_010486529.1 | 885 | PREDICTED: phosphatidate phosphatase PAH1-like [Camelina sativa] |