Gene/Proteome Database (LMPD)
LMPD ID
LMP010786
Gene ID
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
phosphatidylinositol 4-kinase alpha
Gene Symbol
Alternate Names
phosphatidylinositol 4-kinase alpha
Chromosome
1
EC Number
2.7.1.67
Summary
Encodes a phosphatidylinositol 4-kinase that is expressed in inflorescences and shoots.
Orthologs
Proteins
| phosphatidylinositol 4-kinase alpha | |
|---|---|
| Refseq ID | NP_175359 |
| Protein GI | 22330126 |
| UniProt ID | Q9SXA1 |
| mRNA ID | NM_103824 |
| Length | 2028 |
| RefSeq Status | REVIEWED |
| MEALTELCDIIAKNPKQFSEKLAWICGRCPQTEWLLAESPRVSRSHLNAVLAVARIISKNPESIDNRAKSVVNEFLSAIPASFRRSFWPHSFPSQLISSFYCDFLSYLSCAADLSPEFGTEVARFTGEVVIAAIAPSSGDSDGDPAISKAFLVALSQHFPSILQSDGDKLITMLLDQFVLNRAPASPKEQRQQNSANSETDTSSSQGSPISTNRYPSGKTEMASPGDEVASHGSNLSSKSSSSVVMNGGSIVWKSGVDQLSFGFSEGSGGANPVFRQQVASFEDESIESLEKQEIAFRLITHILDKVKIDSKLQDQVRFIAKRQLQSMSAFLKSRKRDWNEQGQVLKTRVNAKLSVYQAAAKMKIKSLVSLETDGKTSKRLVLETLALLLDAADACLTSVWRKMKACEELFDSLLSGIAKIAVARGGQPLRVLLIRLKPLVLAVCALPDQGAMLESIFKTSCVIIESAWAKDRAPVDNFIMGLASSIRERNDYEEQVDREKQVPAVQLNVIRLLADLNVAVKKPEVADMILPLFIESLEEGDASTPSFLRLQLLDAVSRIATLGFDKSYRETVVLMTRSYLSKLSSVGSVESKTSAPEATTERVETLPAGFLTIASGLMDTKLRSDYRHRLLSLCSDVGLAAESKSGGSGVDFLGPLLPAVAEICSDFDPTMDVEPSLLKLFRNLWFYIALFGLAPPIVKTPTPPLKSTSNSVNSVGSMSATALQAVGGPYMWDNQWALAVQRIAQGTPPLVVSSVKWLEDELELNALHNPGSRRGNGNEKVASTQRLALSTALGGRVDVAAMNTISGVKATYLLAVAFLEIIRFISNGGILNGESSVSASRSAFSCVFEYLKTPNLTPAVSQCLTAIVHRAFETAVSWLEDRISLTGKDARNRELTTYAHACFLIKSMSQRDEHVRDISVNLLTQLRDKFPQVLWHSSCLDSLLFSVHDNTPSTVVNDPAWTAAVRSLYQKVVREWIIISLSYAPCTSQGLLQDKLCKANTWQRAQTTTDVVSLLSEIKIGTGKNELWSGIRTANIPAVMAAAAAASGANLKVSEAFNLEVLGTGVVSATVKCNHAGEIAGMRRLYNSIGGFQSGSTPSGFGGGLQRLISGAFSQAPQPEDDSFNEMLIARFVRLLQQFVNTAEKGGEVEKSQFRETCSQATALLLSNLGGESKTNVEGFSQLLRLLCWCPAYISTPDAMETGIFIWTWLVSAAPQLVSLVLAELVDAWIWTIDTKRGLFASDVRYSGPAAKLRPHLSPGEPEDPPESDPVDQIVAHRLWLGFLIDRFEVVRHNSAEQLLLLGRMLQRSTDLEWCFTRHPAAAGTFFSLMLLGLKFCSCQTQGNMQKFRSGLQLLEDRIYRTSLGWFAHQPEWYDVNIPNFCHSEALSVSVFVHFLSNELSESSQSDSKGKPRESGNLIDVTDQYHPVWGEMDNYTLGKEKRKQLLLMLCQHEADRLDVWAQPISSKDSPYSRLKISSEKWTEYAKTAFSVDPRIALSVASRFPANASVKSEVTQLVQTNIVDLRTIPEALPYFVTPKNVEENSVLLQQLPHWAACSITQALEFLTPAYKGHPRVMAYVLRVLESYPPERVTFFMPQLVQSLRYDDGRLVEGYLLRATQRSDIFAHILIWHLQGEDVQETPKDGSIDKNAAFQEILPQVRQHIIDGFSPNALDMFTREFDFFDKVTSISGVLFPLPKEERRAGIRRELEKIEMQGDDLYLPTAPNKLVRGIRVDSGIPLQSAAKVPIMITFNVIDRDGDHSDVKPQACIFKVGDDCRQDVLALQVISLLRDIFQAAGLNLYLFPYGVLPTGAERGIIEVVPNTRSRSQMGETTDGGLYEIFQQDYGPVGSTTFETARENFLISSAGYAVASLLLQPKDRHNGNLLFDDVGRLVHIDFGFILETSPGGNMRFESAHFKLSHEMTQLLDPSGVMKSKTWHQFVSLCVKGYLAARRQMDGIISTVQMMLESGLPCFSRGDPIGNLRKRFHPEMSEREAAHFMIHVCTDAYNKWTTAGYDLIQYLQQGIEK | |
Gene Information
Entrez Gene ID
Gene Name
phosphatidylinositol 4-kinase alpha
Gene Symbol
Species
Arabidopsis thaliana
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0048471 | IDA:UniProtKB | C | perinuclear region of cytoplasm |
| GO:0005886 | IDA:TAIR | C | plasma membrane |
| GO:0009506 | IDA:TAIR | C | plasmodesma |
| GO:0004430 | IDA:UniProtKB | F | 1-phosphatidylinositol 4-kinase activity |
| GO:0051015 | IDA:UniProtKB | F | actin filament binding |
| GO:0070300 | IDA:UniProtKB | F | phosphatidic acid binding |
| GO:0005546 | IDA:UniProtKB | F | phosphatidylinositol-4,5-bisphosphate binding |
| GO:0070273 | IDA:UniProtKB | F | phosphatidylinositol-4-phosphate binding |
| GO:0048015 | IEA:InterPro | P | phosphatidylinositol-mediated signaling |
| GO:0006468 | IDA:TAIR | P | protein phosphorylation |
KEGG Pathway Links
REACTOME Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR016024 | Armadillo-type fold |
| IPR000403 | Phosphatidylinositol 3-/4-kinase, catalytic domain |
| IPR018936 | Phosphatidylinositol 3/4-kinase, conserved site |
| IPR015433 | Phosphatidylinositol Kinase |
| IPR001263 | Phosphoinositide 3-kinase, accessory (PIK) domain |
| IPR011009 | Protein kinase-like domain |
UniProt Annotations
Entry Information
Gene Name
phosphatidylinositol 4-kinase alpha
Protein Entry
P4KA1_ARATH
UniProt ID
Species
Arabidopsis
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate. |
| Disruption Phenotype | Lethal. {ECO:0000269|PubMed:22318862}. |
| Enzyme Regulation | Repressed by PtdIns4P, adenosine and wortmannin, but stimulated by other negatively charged lipids such as PtdIns3P, PtdOH, and phosphatidyl-serine (PtdSer). {ECO:0000269|PubMed:12805633}. |
| Function | Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate. Can bind to phosphatidylinositol 4- monophosphate (PI-4-P or PtdIns4P), phosphatidylinositol 4,5- bisphosphate (PI-4,5-P2 or PtdIns4,5P2), and phosphatidic acid (PtdOH), but not to 3-phosphoinositides. May function upstream of the cold response phosphoinositide-dependent phospholipase C (PI- PLC) pathway. {ECO:0000269|PubMed:22318862, ECO:0000269|PubMed:9712908}. |
| Sequence Caution | Sequence=AAD43164.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; |
| Similarity | Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. {ECO:0000305}. |
| Similarity | Contains 1 PI3K/PI4K domain. {ECO:0000255|PROSITE- ProRule:PRU00269}. |
| Similarity | Contains 1 PIK helical domain. {ECO:0000255|PROSITE- ProRule:PRU00878}. |
| Subcellular Location | Membrane {ECO:0000269|PubMed:12805633}; Peripheral membrane protein {ECO:0000269|PubMed:12805633}; Cytoplasmic side {ECO:0000269|PubMed:12805633}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:12805633}. |
| Subunit | Interacts in vitro with actin filaments via its PH domain. {ECO:0000269|PubMed:12805633}. |
| Tissue Specificity | Present in leaves and inflorescences. {ECO:0000269|PubMed:9712908}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP010786 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 22330126 | RefSeq | NP_175359 | 2028 | phosphatidylinositol 4-kinase alpha |
Identical Sequences to LMP010786 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:22330126 | GenBank | AEE32419.1 | 2028 | phosphatidylinositol 4-kinase alpha [Arabidopsis thaliana] |
| GI:22330126 | GenBank | AEE32420.1 | 2028 | phosphatidylinositol 4-kinase alpha [Arabidopsis thaliana] |
| GI:22330126 | RefSeq | NP_850960.1 | 2028 | phosphatidylinositol 4-kinase alpha [Arabidopsis thaliana] |
| GI:22330126 | SwissProt | Q9SXA1.2 | 2028 | RecName: Full=Phosphatidylinositol 4-kinase alpha 1; Short=PI4-kinase alpha 1; Short=PtdIns-4-kinase alpha 1; AltName: Full=Phosphatidylinositol 4-OH kinase alpha1; Short=AtPI4Kalpha1; Short=PI-4Kalpha1 [Arabidopsis thaliana] |
Related Sequences to LMP010786 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:22330126 | GenBank | AAD43164.1 | 2051 | Putative Phosphatidylinositol 4-kinase PI4K [Arabidopsis thaliana] |
| GI:22330126 | GenBank | AAC32803.2 | 2028 | phosphatidylinositol 4-kinase [Arabidopsis thaliana] |
| GI:22330126 | GenBank | EFH67751.1 | 2018 | phosphatidylinositol 4-kinase [Arabidopsis lyrata subsp. lyrata] |
| GI:22330126 | GenBank | EOA39473.1 | 2029 | hypothetical protein CARUB_v10008069mg [Capsella rubella] |
| GI:22330126 | RefSeq | XP_002891492.1 | 2018 | phosphatidylinositol 4-kinase [Arabidopsis lyrata subsp. lyrata] |
| GI:22330126 | RefSeq | XP_006306575.1 | 2029 | hypothetical protein CARUB_v10008069mg [Capsella rubella] |