Gene/Proteome Database (LMPD)
LMPD ID
LMP010787
Gene ID
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
phosphatidylinositol 4-OH kinase beta1
Gene Symbol
Synonyms
MHJ24.5; MHJ24_5; phosphatidylinositol 4-OH kinase beta1; PHOSPHATIDYLINOSITOL 4-OH KINASE BETA1; PI-4KBETA1; PI4KBETA1
Alternate Names
phosphatidylinositol 4-OH kinase beta1
Chromosome
5
EC Number
2.7.1.67
Proteins
| phosphatidylinositol 4-OH kinase beta1 | |
|---|---|
| Refseq ID | NP_201212 |
| Protein GI | 15237610 |
| UniProt ID | Q9FMJ0 |
| mRNA ID | NM_125803 |
| Length | 1121 |
| RefSeq Status | REVIEWED |
| MPMGRFLSLVRGDSAESPREITSQSNIIGDTGSNGWLIRFFDSAFFCEWIAVSYLYKHPHAGVRDYLCNRMYTLPLSGIESYLFQICYMMVHKPSPSLDKFVIDICGKSLKIALKVHWFLLAELEDADDNEGISRIQEKCQIAATLMGEWSPLMRPQNEVSTPGSKNQVLNRLLSSKQKLFSLKLSPPTQKSLSFSPSPGTNVQDDGSQLPAEDNKIFKKLIPSPKVRDALMFRKSADKDDEESEKEGFFKRLLRDSKGEGDEPIPNSEGFFKRLLKDNKSEDEDITNSSEGFFKRLLSSKGESEELTSSSDGLFKRLLRDNKGDEEELGANSDSFFKRLLRESKNEDEESNPNSEGFFKKLFRDSKPEDDKVPKEVDDEDKDGFLKKLFREKNDDKRHGSEKNEANGTVYADKKSGEEDEREGFFKKFFKEKSDDKKDIVKVDDGNESEGDESPEFSLFKRLFRIHPEDAKPTSENENSSNGLVESSPGTENFFRKLFRDRDQSVEDSELFGSKKHKEKRPGSPKQRDDTPSGKPPLPNNTASQFRKGAYHESLEFVQALCETSYGLVDIFPIEDRKIGLRESLAEINFHLSEAEITGGICFPMGRGVFRVVHIPEDECILLNSREKAPYMISVEVLKAETPSAKESSNSQKLSKGGIPLANGDAFLQKPPPWAYPLWTTQEVYRNSADRMSLSTAQAIDQAMTPKSEVKVKLVNVSLSVEDRTSALESFGDPIDDVLGEAPRTGLNNDLEWVRVVVTADPGLRMESIPDPSVPRKKEHRRVPSTVAMEEVRAAAAKGEAPPGLPLKGAGQDSSDAQPRANGGMLKEGDALSGELWEGKRDRIRKASIYGKLPGWDLRSIIVKSGDDCRQEHLAVQLISHFYDIFQEAGLPLWLRPYEVLVTSSYTALIETIPDTASIHSIKSRYPNITSLRDFFVAKYKENSPSFKLAQRNFVESMAGYSLVCYLLQVKDRHNGNLLLDEEGHIIHIDFGFMLSNSPGGVNFESAPFKLTRELLEVMDSDADGVPSEFFDYFKVLCIQGFLTCRKHAERIILLVEMLQDSGFPCFKGGPRTIQNLRKRFHLSLTEEQCVSLVLSLISSSLDAWRTRQYDYYQRVLNGIL | |
Gene Information
Entrez Gene ID
Gene Name
phosphatidylinositol 4-OH kinase beta1
Gene Symbol
Species
Arabidopsis thaliana
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005794 | IEA:UniProtKB-KW | C | Golgi apparatus |
| GO:0030659 | IDA:UniProtKB | C | cytoplasmic vesicle membrane |
| GO:0005829 | IDA:TAIR | C | cytosol |
| GO:0016020 | IDA:TAIR | C | membrane |
| GO:0005634 | IDA:TAIR | C | nucleus |
| GO:0005886 | IDA:UniProtKB | C | plasma membrane |
| GO:0035619 | IDA:TAIR | C | root hair tip |
| GO:0004430 | IDA:UniProtKB | F | 1-phosphatidylinositol 4-kinase activity |
| GO:0017137 | IPI:UniProtKB | F | Rab GTPase binding |
| GO:0043424 | IPI:UniProtKB | F | protein histidine kinase binding |
| GO:0006661 | IEA:InterPro | P | phosphatidylinositol biosynthetic process |
| GO:0048015 | IEA:InterPro | P | phosphatidylinositol-mediated signaling |
| GO:0009860 | IGI:TAIR | P | pollen tube growth |
| GO:0048768 | IGI:TAIR | P | root hair cell tip growth |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ath00562 | Inositol phosphate metabolism |
| ath01100 | Metabolic pathways |
| ath04070 | Phosphatidylinositol signaling system |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 6254337 | Synthesis of PIPs at the Golgi membrane |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR016024 | Armadillo-type fold |
| IPR000403 | Phosphatidylinositol 3-/4-kinase, catalytic domain |
| IPR018936 | Phosphatidylinositol 3/4-kinase, conserved site |
| IPR027003 | Phosphatidylinositol 4-kinase |
| IPR015433 | Phosphatidylinositol Kinase |
| IPR001263 | Phosphoinositide 3-kinase, accessory (PIK) domain |
| IPR011009 | Protein kinase-like domain |
UniProt Annotations
Entry Information
Gene Name
phosphatidylinositol 4-OH kinase beta1
Protein Entry
P4KB1_ARATH
UniProt ID
Species
Arabidopsis
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate. |
| Disruption Phenotype | When associated with PI4KB2 disruption: aberrant root hair morphologies, and short and wavy pollen tubes. {ECO:0000269|PubMed:16567499, ECO:0000269|PubMed:19208902}. |
| Domain | The PPC (Plant PI4K Charged) region is involved in membrane targeting and phospholipid binding. {ECO:0000269|PubMed:16649109}. |
| Enzyme Regulation | Stimulated by phosphatidylinositol 4-phosphate (PtdIns4P). Slightly repressed by phosphatidyl-choline (PtdCho), wortmannin and adenosine. {ECO:0000269|PubMed:10026194, ECO:0000269|PubMed:12805633}. |
| Function | Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5-trisphosphate. Necessary for proper organization of the trans-Golgi network (TGN) and post-Golgi secretion in root hairs. Together with PI4KB2, required during polarized root hair expansion and pollen tube elongation. Functions redundantly with PI4KB2 upstream of the cold response phosphoinositide-dependent phospholipase C (PI-PLC) pathway. {ECO:0000269|PubMed:10026194, ECO:0000269|PubMed:16567499, ECO:0000269|PubMed:19208902, ECO:0000269|PubMed:20603382, ECO:0000269|PubMed:21134079, ECO:0000269|PubMed:22318862}. |
| Interaction | Q9C5U2:AHK2; NbExp=2; IntAct=EBI-1807432, EBI-1100634; |
| Similarity | Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. {ECO:0000305}. |
| Similarity | Contains 1 PI3K/PI4K domain. {ECO:0000255|PROSITE- ProRule:PRU00269}. |
| Similarity | Contains 1 PIK helical domain. {ECO:0000255|PROSITE- ProRule:PRU00878}. |
| Subcellular Location | Cell membrane. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated to tip-localized membranes in growing root hairs. |
| Subunit | Interacts with AHK2, CBL1 and RABA4D. {ECO:0000269|PubMed:16567499, ECO:0000269|PubMed:18642946, ECO:0000269|PubMed:19208902}. |
| Tissue Specificity | Expressed constitutively in leaves, roots, flowers, and stems. {ECO:0000269|PubMed:10026194}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP010787 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 15237610 | RefSeq | NP_201212 | 1121 | phosphatidylinositol 4-OH kinase beta1 |
Identical Sequences to LMP010787 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:15237610 | EMBL | CBD23873.1 | 1121 | unnamed protein product [Arabidopsis thaliana] |
| GI:15237610 | EMBL | CBD23944.1 | 1121 | unnamed protein product [Arabidopsis thaliana] |
| GI:15237610 | EMBL | CBD23946.1 | 1121 | unnamed protein product [Arabidopsis thaliana] |
| GI:15237610 | EMBL | CBD19631.1 | 1121 | unnamed protein product [Arabidopsis thaliana] |
| GI:15237610 | EMBL | CBD19633.1 | 1121 | unnamed protein product [Arabidopsis thaliana] |
| GI:15237610 | gnl | TAIR | 1121 | phosphatidylinositol 4-OH kinase beta1 [Arabidopsis thaliana] |
Related Sequences to LMP010787 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:15237610 | EMBL | CAV28065.1 | 1121 | unnamed protein product [Arabidopsis thaliana] |
| GI:15237610 | EMBL | CBD20567.1 | 1121 | unnamed protein product [Arabidopsis thaliana] |
| GI:15237610 | EMBL | CBD23447.1 | 1121 | unnamed protein product [Arabidopsis thaliana] |
| GI:15237610 | EMBL | CBD21243.1 | 1121 | unnamed protein product [Arabidopsis thaliana] |
| GI:15237610 | EMBL | CBD19319.1 | 1121 | unnamed protein product [Arabidopsis thaliana] |
| GI:15237610 | EMBL | CBD23877.1 | 1121 | unnamed protein product [Arabidopsis thaliana] |