Gene/Proteome Database (LMPD)

LMPD ID
LMP010788
Gene ID
830794
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
phosphatidylinositol 4-OH kinase beta2
Gene Symbol
PI-4KBETA2
Synonyms
phosphatidylinositol 4-OH kinase beta2; PHOSPHATIDYLINOSITOL 4-OH KINASE BETA2; PI-4KBETA2; PI4KBETA2; T5E8.150; T5E8_150
Alternate Names
phosphatidylinositol 4-OH kinase beta2
Chromosome
5
EC Number
2.7.1.67

Proteins

phosphatidylinositol 4-OH kinase beta2
Refseq ID NP_196497
Protein GI 15242394
UniProt ID Q0WPX9
mRNA ID NM_120971
Length 1116
RefSeq Status REVIEWED
MQMAQFLSLVRGDSIESPREITSPSNLISESGSNGWLIRFFDSSFFCEWIAVSYLYKHQHSGVRDYLCNRMYTLPLSGIESYLFQICYLMVHKPSPSLDKFVIDICAKSLKIALKVHWFLLAELEDSDDNEGISRIQEKCQIAATLVGEWSPLMRPHNEPSTPGSKVLNKFLSSKQKLFSLTLSPPTQKSLLFSPTSGSNLQDDGSQLSADDNKIFKRLIPSPKVRDALLFRKSADKEDEECEKDGFFKRLLRDSRGEDDEQRSNSEGFFKRLLKDNKSEEEEISNNSEGFFKRLRSSKGDEEELTSSSDGFFKRLLRDNKGDEEELGANSEGFFKKLLRDSKNEDEEPNANTEGFFKKLFHESKNEDDKVSNAVDDEEKDGFLKKLFKEKFDEKRNGNERNETDETVYTDETSGEDNGREGFFKKLFKEKFEDKPNIGKADDGNESEDDESSEFSLFRRLFRRHPEDVKTTLPSENCSNGGFVESSPGTENFFRKLFRDRDRSVEDSELFGSKKYKEKCPGSPKPQNNTPSKKPPLPNNTAAQFRKGSYHESLEFVHALCETSYDLVDIFPIEDRKTALRESIAEINSHLAQAETTGGICFPMGRGVYRVVNIPEDEYVLLNSREKVPYMICVEVLKAETPCGAKTTSTSLKLSKGGIPLANGDAFLHKPPPWAYPLSTAQEVYRNSADRMSLSTVEAIDQAMTHKSEVKLVNACLSVETHSNSNTKSVSSGVTGVLRTGLESDLEWVRLVLTADPGLRMESITDPKTPRRKEHRRVSSIVAYEEVRAAAAKGEAPPGLPLKGAGQDSSDAQPMANGGMLKAGDALSGEFWEGKRLRIRKDSIYGNLPGWDLRSIIVKSGDDCRQEHLAVQLISHFFDIFQEAGLPLWLRPYEVLVTSSYTALIETIPDTASIHSIKSRYPNITSLRDFFDAKFKENSPSFKLAQRNFVESMAGYSLVCYLLQIKDRHNGNLLMDEEGHIIHIDFGFMLSNSPGGVNFESAPFKLTRELLEVMDSDAEGLPSEFFDYFKVLCIQGFLTCRKHAERIILLVEMLQDSGFPCFKGGPRTIQNLRKRFHLSLTEEQCVSLVLSLISSSLDAWRTRQYDYYQRVLNGIR

Gene Information

Entrez Gene ID
830794
Gene Name
phosphatidylinositol 4-OH kinase beta2
Gene Symbol
PI-4KBETA2
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0030659 ISS:UniProtKB C cytoplasmic vesicle membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0004430 ISS:UniProtKB F 1-phosphatidylinositol 4-kinase activity
GO:0006661 IEA:InterPro P phosphatidylinositol biosynthetic process
GO:0048015 IEA:InterPro P phosphatidylinositol-mediated signaling
GO:0009860 IGI:TAIR P pollen tube growth
GO:0048768 IGI:TAIR P root hair cell tip growth

KEGG Pathway Links

KEGG Pathway ID Description
ath00562 Inositol phosphate metabolism
ath01100 Metabolic pathways
ath04070 Phosphatidylinositol signaling system

REACTOME Pathway Links

REACTOME Pathway ID Description
6254337 Synthesis of PIPs at the Golgi membrane

Domain Information

InterPro Annotations

Accession Description
IPR016024 Armadillo-type fold
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
IPR027003 Phosphatidylinositol 4-kinase
IPR015433 Phosphatidylinositol Kinase
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
IPR011009 Protein kinase-like domain

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol 4-OH kinase beta2
Protein Entry
P4KB2_ARATH
UniProt ID
Q0WPX9
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.
Disruption Phenotype When associated with PI4KB1 disruption: aberrant root hair morphologies, and short and wavy pollen tubes. {ECO:0000269|PubMed:16567499, ECO:0000269|PubMed:19208902}.
Domain The PPC (Plant PI4K Charged) region is involved in membrane targeting and phospholipid binding. {ECO:0000250}.
Function Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5-trisphosphate (By similarity). Necessary for proper organization of the trans-Golgi network (TGN) and post-Golgi secretion in root hairs. Together with PI4KB1, required during polarized root hair expansion and pollen tube elongation. Functions redundantly with PI4KB1 upstream of the cold response phosphoinositide-dependent phospholipase C (PI-PLC) pathway. {ECO:0000250, ECO:0000269|PubMed:16567499, ECO:0000269|PubMed:19208902, ECO:0000269|PubMed:21134079, ECO:0000269|PubMed:22318862}.
Sequence Caution Sequence=CAC05461.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. {ECO:0000305}.
Similarity Contains 1 PI3K/PI4K domain. {ECO:0000255|PROSITE- ProRule:PRU00269}.
Similarity Contains 1 PIK helical domain. {ECO:0000255|PROSITE- ProRule:PRU00878}.
Subcellular Location Cell membrane {ECO:0000250}. Golgi apparatus, trans-Golgi network {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010788 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15242394 RefSeq NP_196497 1116 phosphatidylinositol 4-OH kinase beta2

Identical Sequences to LMP010788 proteins

Reference Database Accession Length Protein Name
GI:15242394 EMBL CBD21238.1 1116 unnamed protein product [Arabidopsis thaliana]
GI:15242394 EMBL CBD19314.1 1116 unnamed protein product [Arabidopsis thaliana]
GI:15242394 EMBL CBD23872.1 1116 unnamed protein product [Arabidopsis thaliana]
GI:15242394 EMBL CBD23945.1 1116 unnamed protein product [Arabidopsis thaliana]
GI:15242394 EMBL CBD19632.1 1116 unnamed protein product [Arabidopsis thaliana]
GI:15242394 gnl TAIR 1116 phosphatidylinositol 4-OH kinase beta2 [Arabidopsis thaliana]

Related Sequences to LMP010788 proteins

Reference Database Accession Length Protein Name
GI:15242394 EMBL CAV28063.1 1120 unnamed protein product [Arabidopsis thaliana]
GI:15242394 EMBL CBD20565.1 1120 unnamed protein product [Arabidopsis thaliana]
GI:15242394 EMBL CBD23445.1 1120 unnamed protein product [Arabidopsis thaliana]
GI:15242394 EMBL CBD21241.1 1120 unnamed protein product [Arabidopsis thaliana]
GI:15242394 EMBL CBD19317.1 1120 unnamed protein product [Arabidopsis thaliana]
GI:15242394 EMBL CBD23875.1 1120 unnamed protein product [Arabidopsis thaliana]