Gene/Proteome Database (LMPD)

LMPD ID
LMP010799
Gene ID
844110
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
phosphatidylinositol-4-phosphate 5-kinase 2
Gene Symbol
PIP5K2
Synonyms
phosphatidylinositol-4-phosphate 5-kinase 2; PIP5K2
Alternate Names
phosphatidylinositol-4-phosphate 5-kinase 2
Chromosome
1
EC Number
2.7.1.68
Summary
Encodes PIP5K2, a phosphatidylinositol-4-phosphate 5-kinase (PtdIns(4)P 5-kinase 2; or PIP5K2).
Orthologs
View orthologs and multiple alignments for PIP5K2

Proteins

phosphatidylinositol-4-phosphate 5-kinase 2
Refseq ID NP_177897
Protein GI 15217451
UniProt ID Q8L796
mRNA ID NM_106423
Length 754
RefSeq Status REVIEWED
MMREPLVSEEEEEEATEVLLVEKTKLCKRRGDEEKTEERRDDLLLLALTPMVRSKSQGTTRRVTPTPPPVDVEKPLPNGDLYMGTFSGGFPNGSGKYLWKDGCMYEGEWKRGKASGKGKFSWPSGATYEGEFKSGRMEGSGTFVGVDGDTYRGSWVADRKQGHGQKRYANGDYYEGTWRRNLQDGRGRYVWMNGNQYTGEWRNGVICGKGVLAWPNGNRYEGQWENGVPKGSGVFTWADGSSWIGSWNESSNLMRNFFDGIEKNELIVATRKRSSVDSGAGSLTGEKIFPRICIWESDGEAGDITCDIVDNVEASVIYRDRISIDKDGFRQFRKNPCCFSGEAKKPGETISKGHKKYDLMLNLQHGIRYSVGKHASVVRDLKQSDFDPSEKFWTRFPPEGSKTTPPHLSVDFRWKDYCPLVFRRLRELFTVDPADYMLAICGNDALRELSSPGKSGSFFYLTQDDRFMIKTVKKSEVKVLLRMLPSYYKHVCQYENTLVTRFYGVHCIKPVGGQKTRFIVMGNLFCSEYRIQRRFDLKGSSHGRYTSKPEGEIDETTTLKDLDLNFAFRLQRNWYQELMTQIKRDCEFLEAERIMDYSLLVGVHFRDDNTGDKMGLSPFVLRSGKIESYQSEKFMRGCRFLEAELQDMDRILAGRKPLIRLGANMPARAERMARRSDYDQYSSGGTNYQSHGEVYEVVLYFGIIDILQDYDISKKIEHAYKSLQADPASISAVDPKLYSRRFRDFISRIFIEDG

Gene Information

Entrez Gene ID
844110
Gene Name
phosphatidylinositol-4-phosphate 5-kinase 2
Gene Symbol
PIP5K2
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005886 IDA:TAIR C plasma membrane
GO:0016308 IDA:TAIR F 1-phosphatidylinositol-4-phosphate 5-kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0003006 IMP:TAIR P developmental process involved in reproduction
GO:0040007 IMP:TAIR P growth
GO:0010311 IMP:TAIR P lateral root formation
GO:0046854 IDA:GOC P phosphatidylinositol phosphorylation
GO:0009958 IMP:TAIR P positive gravitropism

KEGG Pathway Links

KEGG Pathway ID Description
ath04144 Endocytosis
ath00562 Inositol phosphate metabolism
ath01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
6254333 Synthesis of PIPs at the plasma membrane

Domain Information

InterPro Annotations

Accession Description
IPR003409 MORN motif
IPR023610 Phosphatidylinositol-4-phosphate 5-kinase
IPR002498 Phosphatidylinositol-4-phosphate 5-kinase, core
IPR016034 Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup
IPR027483 Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
IPR027484 Phosphatidylinositol-4-phosphate 5-kinase, N-terminal domain
IPR017163 Phosphatidylinositol-4-phosphate 5-kinase, plant

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol-4-phosphate 5-kinase 2
Protein Entry
PI5K2_ARATH
UniProt ID
Q8L796
Species
Arabidopsis

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8L796-1; Sequence=Displayed; Name=2; IsoId=Q8L796-2; Sequence=VSP_015946; Note=May be due to intron retention. No experimental confirmation available.;
Catalytic Activity ATP + 1-phosphatidyl-1D-myo-inositol 4- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
Enzyme Regulation Activated by binding to RABE1D.
Function Possesses phosphatidylinositol kinase activity in vitro. {ECO:0000269|PubMed:19903693}.
Miscellaneous Plants overexpressing PI5K2 exhibit severe dwarfism and are enriched in the plasma membrane of the root meristem. {ECO:0000305|PubMed:19903693}.
Similarity Contains 1 PIPK domain. {ECO:0000255|PROSITE- ProRule:PRU00781}.
Similarity Contains 7 MORN repeats. {ECO:0000305}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:19903693}.
Subunit Interacts with RABE1A, TUFA, RABE1C, RABE1D and RABE1E. {ECO:0000269|PubMed:19903693}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010799 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15217451 RefSeq NP_177897 754 phosphatidylinositol-4-phosphate 5-kinase 2

Identical Sequences to LMP010799 proteins

Reference Database Accession Length Protein Name
GI:15217451 EMBL CAM55399.1 754 unnamed protein product [Arabidopsis thaliana]
GI:15217451 GenBank AAG51623.1 754 putative phosphatidylinositol-4-phosphate-5-kinase; 27989-31218 [Arabidopsis thaliana]
GI:15217451 GenBank AEE36015.1 754 phosphatidylinositol-4-phosphate 5-kinase 2 [Arabidopsis thaliana]
GI:15217451 GenBank AFL61115.1 754 Sequence 86 from patent US 8106253
GI:15217451 SwissProt Q8L796.2 754 RecName: Full=Phosphatidylinositol 4-phosphate 5-kinase 2; Short=AtPIP5K2; AltName: Full=1-phosphatidylinositol 4-phosphate kinase 2; AltName: Full=Diphosphoinositide kinase 2; AltName: Full=PtdIns(4)P-5-kinase 2 [Arabidopsis thaliana]

Related Sequences to LMP010799 proteins

Reference Database Accession Length Protein Name
GI:15217451 GenBank EFH63958.1 757 hypothetical protein ARALYDRAFT_476937 [Arabidopsis lyrata subsp. lyrata]
GI:15217451 GenBank EOA33674.1 754 hypothetical protein CARUB_v10019857mg [Capsella rubella]
GI:15217451 RefSeq XP_002887699.1 757 hypothetical protein ARALYDRAFT_476937 [Arabidopsis lyrata subsp. lyrata]
GI:15217451 RefSeq XP_006300776.1 754 hypothetical protein CARUB_v10019857mg [Capsella rubella]
GI:15217451 RefSeq XP_010428859.1 760 PREDICTED: phosphatidylinositol 4-phosphate 5-kinase 2-like [Camelina sativa]
GI:15217451 RefSeq XP_010471971.1 749 PREDICTED: phosphatidylinositol 4-phosphate 5-kinase 2 [Camelina sativa]