Gene/Proteome Database (LMPD)

LMPD ID
LMP010801
Gene ID
824863
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
phosphatidylinositol-4-phosphate 5-kinase 4
Gene Symbol
PIP5K4
Synonyms
phosphatidyl inositol monophosphate 5 kinase 4; PIP5K4; T8M16.6
Alternate Names
phosphatidylinositol-4-phosphate 5-kinase 4
Chromosome
3
EC Number
2.7.1.68
Summary
Encodes a protein with phosphatidylinositol-4-phosphate 5-kinase activity that plays a role in pollen tip growth. The enzyme localizes to the apical plasma membrane and adjacent cytosolic region of pollen tubes. Overexpression of this gene leads to increased deposition of pectin in the cell wall at the tip of the pollen tube and causes altered pollen tube morphology.
Orthologs
View orthologs and multiple alignments for PIP5K4

Proteins

phosphatidylinositol-4-phosphate 5-kinase 4
Refseq ID NP_191255
Protein GI 15230176
UniProt ID Q9M1K2
mRNA ID NM_115555
Length 779
RefSeq Status REVIEWED
MSKEQSCVLKAWEVTVRKTQQAKKRANSIFGTVSVAPQTDDDATTTTEENDDETSTNRSSIGELYHAERILPNGDYYTGQWYDSFPHGHGKYLWTDGCMYIGDWYNGKTMGRGKFGWPSGATYEGEFKSGYMDGVGLYTGPSGDTYKGQWVMNLKHGHGIKRFANGDVYDGEWRRGLQEAQGKYQWRDGSYYMGEWKNATICGKGTFIWTDGNRYDGFWDDGFPRGNGTFKWADGSFYVGHWSNDPEEMNGTYYPSGDDGSPEWDPKDVFTNLSEYKICSGERVPVLPSQKKLSVWNSSKRVEKPRRMSVDGRVSVGVDRAFEKMNMWGTESGEGAADIDSTTRRDLDAEMMRLEAEGFIQSLRPSPAPMRLPRAGRKQGETISKGHRNYELMLNLQLGIRHAVGKQAPVVSLDLKHSAFDPKEKVWTRFPPEGTKYTPPHQSSEFKWKDYCPLVFRSLRKLFKVDPADYMLSICGNDALRELSSPGKSGSFFYLTNDDRYMIKTMKKSETKVLLRMLAAYYNHVRAFENTLVIRFYGLHCVKLTGPIQKKVRFVIMGNLFCSEYSIHRRFDLKGSSLGRTTDKPESEINSNTILKDLDLNFIFRLQKAWYQEFIRQVDKDCEFLEQERIMDYSLLVGIHFREASVAGELIPSGARTPIGEFEDESAPRLSRADVDQLLSDPTRWASIRLGGNMPARAERTMRRSDCEFQLVGEPTGEYYEVVMIFGIIDILQDYDISKKLEHAYKSIQYDPTSISAVDPRLYSRRFRDFIFKVFTEDN

Gene Information

Entrez Gene ID
824863
Gene Name
phosphatidylinositol-4-phosphate 5-kinase 4
Gene Symbol
PIP5K4
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016324 IDA:TAIR C apical plasma membrane
GO:0005829 IDA:TAIR C cytosol
GO:0005886 IDA:TAIR C plasma membrane
GO:0090406 IDA:TAIR C pollen tube
GO:0016308 IDA:TAIR F 1-phosphatidylinositol-4-phosphate 5-kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0006897 IMP:TAIR P endocytosis
GO:0007164 IMP:TAIR P establishment of tissue polarity
GO:0046488 IDA:TAIR P phosphatidylinositol metabolic process
GO:0046854 IDA:GOC P phosphatidylinositol phosphorylation
GO:0009827 IMP:TAIR P plant-type cell wall modification
GO:0009846 IGI:TAIR P pollen germination
GO:0009860 IMP:TAIR P pollen tube growth
GO:0010118 IMP:TAIR P stomatal movement

KEGG Pathway Links

KEGG Pathway ID Description
ath04144 Endocytosis
ath00562 Inositol phosphate metabolism
ath01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
6254333 Synthesis of PIPs at the plasma membrane

Domain Information

InterPro Annotations

Accession Description
IPR003409 MORN motif
IPR023610 Phosphatidylinositol-4-phosphate 5-kinase
IPR027483 Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
IPR027484 Phosphatidylinositol-4-phosphate 5-kinase, N-terminal domain
IPR002498 Phosphatidylinositol-4-phosphate 5-kinase, core
IPR016034 Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup
IPR017163 Phosphatidylinositol-4-phosphate 5-kinase, plant

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol-4-phosphate 5-kinase 4
Protein Entry
PI5K4_ARATH
UniProt ID
Q9M1K2
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity ATP + 1-phosphatidyl-1D-myo-inositol 4- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
Similarity Contains 1 PIPK domain. {ECO:0000255|PROSITE- ProRule:PRU00781}.
Similarity Contains 8 MORN repeats. {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010801 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15230176 RefSeq NP_191255 779 phosphatidylinositol-4-phosphate 5-kinase 4

Identical Sequences to LMP010801 proteins

Reference Database Accession Length Protein Name
GI:15230176 EMBL CAW93754.1 779 unnamed protein product [Arabidopsis thaliana]
GI:15230176 EMBL CBD28807.1 779 unnamed protein product [Arabidopsis thaliana]
GI:15230176 EMBL CBD33927.1 779 unnamed protein product [Arabidopsis thaliana]
GI:15230176 EMBL CBC95692.1 779 unnamed protein product [Arabidopsis thaliana]
GI:15230176 GenBank AEE79593.1 779 phosphatidylinositol-4-phosphate 5-kinase 4 [Arabidopsis thaliana]
GI:15230176 SwissProt Q9M1K2.1 779 RecName: Full=Phosphatidylinositol 4-phosphate 5-kinase 4; Short=AtPIP5K4; AltName: Full=1-phosphatidylinositol 4-phosphate kinase 4; AltName: Full=Diphosphoinositide kinase 4; AltName: Full=PtdIns(4)P-5-kinase 4 [Arabidopsis thaliana]

Related Sequences to LMP010801 proteins

Reference Database Accession Length Protein Name
GI:15230176 GenBank EFH52649.1 779 predicted protein [Arabidopsis lyrata subsp. lyrata]
GI:15230176 RefSeq XP_002876390.1 779 predicted protein [Arabidopsis lyrata subsp. lyrata]
GI:15230176 RefSeq XP_010516300.1 779 PREDICTED: phosphatidylinositol 4-phosphate 5-kinase 4 [Camelina sativa]
GI:15230176 RefSeq XP_010427550.1 779 PREDICTED: phosphatidylinositol 4-phosphate 5-kinase 4-like [Camelina sativa]
GI:15230176 RefSeq XP_010427551.1 779 PREDICTED: phosphatidylinositol 4-phosphate 5-kinase 4-like [Camelina sativa]
GI:15230176 RefSeq XP_010427552.1 779 PREDICTED: phosphatidylinositol 4-phosphate 5-kinase 4-like [Camelina sativa]