Gene/Proteome Database (LMPD)

LMPD ID
LMP010822
Gene ID
818371
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
inositol phosphorylceramide synthase 2
Gene Symbol
AtIPCS2
Synonyms
Arabidopsis Inositol phosphorylceramide synthase 2; AtIPCS2; T8P21.15; T8P21_15
Alternate Names
inositol phosphorylceramide synthase 2
Chromosome
2
EC Number
2.7.8.-
Summary
I
Orthologs
View orthologs and multiple alignments for AtIPCS2

Proteins

inositol phosphorylceramide synthase 2
Refseq ID NP_565875
Protein GI 18404594
UniProt ID Q9SH93
mRNA ID NM_129350
Length 305
RefSeq Status REVIEWED
MTLYIRRESSKLWKRFCSEISTEIGLLAENWKYLLAGLICQYIHGLAAKGVHYIHRPGPTLQDLGFFLLPELGQERSYISETVFTSVFLSFFLWTFHPFILKTKKIYTVLIWCRVLAFLVACQFLRVITFYSTQLPGPNYHCREGSKVSRLPWPKSALEVLEINPHGVMYGCGDLIFSSHMIFTLVFVRTYQKYGTKRFIKLFGWLTAIVQSLLIIASRKHYSVDVVVAWYTVNLVVFCLDKKLPELPDRTAVLLPVISKDRTKEENHKLLNGNGVDPADWRPRAQVNGKIDSNGVHTDNTMNGA

Gene Information

Entrez Gene ID
818371
Gene Name
inositol phosphorylceramide synthase 2
Gene Symbol
AtIPCS2
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005802 IDA:TAIR C trans-Golgi network
GO:0045140 IDA:TAIR F inositol phosphoceramide synthase activity
GO:0006952 IEA:UniProtKB-KW P defense response
GO:0030148 IDA:TAIR P sphingolipid biosynthetic process

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-5129 sphingolipid biosynthesis (plants)
PWY-5129 sphingolipid biosynthesis (plants)

Domain Information

InterPro Annotations

Accession Description
IPR025749 Sphingomyelin synthase-like domain

UniProt Annotations

Entry Information

Gene Name
inositol phosphorylceramide synthase 2
Protein Entry
IPCS2_ARATH
UniProt ID
Q9SH93
Species
Arabidopsis

Comments

Comment Type Description
Disruption Phenotype Constitutive RPW8-mediated HR-like cell death characterized by salicylic acid (SA) accumulation, enhanced transcription of RPW8 and RPW8-dependent spontaneous HR-like cell death (SHL) in leaf tissues. Reduced plant stature. Sphingolipid (e.g. ceramides and hydroxyceramides) accumulation associated with a reduced inositol-phosphorylceramide synthase (IPCS) activity. {ECO:0000269|PubMed:19001565}.
Function Catalyzes the transfer of the phosphorylinositol group from phosphatidylinositol (PI) to phytoceramide, an essential step in sphingolipid biosynthesis. May play an important role in modulating plant programmed cell death (PCD) associated with defense (e.g. toward Golovinomyces cichoracearum) by promoting sphingolipid metabolism and thus regulating ceramide accumulation. {ECO:0000269|PubMed:19001565, ECO:0000269|PubMed:20309609}.
Induction By powdery mildew (e.g. Golovinomyces cichoracearum and Pseudomonas syringae) inoculation. {ECO:0000269|PubMed:19001565}.
Similarity Belongs to the sphingomyelin synthase family. {ECO:0000305}.
Subcellular Location Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:19001565}; Multi-pass membrane protein {ECO:0000269|PubMed:19001565}.
Tissue Specificity Expressed in leaves, roots, stems, flowers and siliques. {ECO:0000269|PubMed:19001565, ECO:0000269|PubMed:20309609}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010822 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18404594 RefSeq NP_565875 305 inositol phosphorylceramide synthase 2

Identical Sequences to LMP010822 proteins

Reference Database Accession Length Protein Name
GI:18404594 EMBL CBD12178.1 305 unnamed protein product [Arabidopsis thaliana]
GI:18404594 EMBL CBC95341.1 305 unnamed protein product [Arabidopsis thaliana]
GI:18404594 EMBL CBD02133.1 305 unnamed protein product [Arabidopsis thaliana]
GI:18404594 EMBL CBC92946.1 305 unnamed protein product [Arabidopsis thaliana]
GI:18404594 GenBank ADT59712.1 305 Sequence 314 from patent US 7847156
GI:18404594 GenBank AEC09468.1 305 inositol phosphorylceramide synthase 2 [Arabidopsis thaliana]

Related Sequences to LMP010822 proteins

Reference Database Accession Length Protein Name
GI:18404594 GenBank EFH55975.1 305 hypothetical protein ARALYDRAFT_482800 [Arabidopsis lyrata subsp. lyrata]
GI:18404594 GenBank EOA27567.1 305 hypothetical protein CARUB_v10023705mg [Capsella rubella]
GI:18404594 RefSeq XP_002879716.1 305 hypothetical protein ARALYDRAFT_482800 [Arabidopsis lyrata subsp. lyrata]
GI:18404594 RefSeq XP_006294669.1 305 hypothetical protein CARUB_v10023705mg [Capsella rubella]
GI:18404594 RefSeq XP_010509254.1 305 PREDICTED: phosphatidylinositol:ceramide inositolphosphotransferase 2 [Camelina sativa]
GI:18404594 RefSeq XP_010517074.1 305 PREDICTED: phosphatidylinositol:ceramide inositolphosphotransferase 2 [Camelina sativa]