Gene/Proteome Database (LMPD)

LMPD ID
LMP010847
Gene ID
830010
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
putative phosphoinositide phospholipase C 3
Gene Symbol
PLC1
Synonyms
ATPLC1; phospholipase C1; PLC1
Alternate Names
putative phosphoinositide phospholipase C 3
Chromosome
4
EC Number
3.1.4.11
Summary
Encodes a putative phosphoinositide-specific phospholipase C. There are two genes called ATPLC1, one corresponding to AT4g38530 (this one) and one corresponding to AT5g58670.
Orthologs
View orthologs and multiple alignments for PLC1

Proteins

putative phosphoinositide phospholipase C 3
Refseq ID NP_195565
Protein GI 79499922
UniProt ID Q56W08
mRNA ID NM_120014
Length 564
RefSeq Status REVIEWED
MSESFKVCFCCSRSFKEKTRQPPVSIKRLFEAYSRNGKMSFDELLRFVSEVQGERHAGLDYVQDIFHSVKHHNVFHHHGLVHLNAFYRYLFSDTNSPLPMSGQVHHDMKAPLSHYFVYTGHNSYLTGNQVNSRSSVEPIVQALRKGVKVIELDLWPNPSGNAAEVRHGRTLTSHEDLQKCLTAIKDNAFHVSDYPVIITLEDHLPPKLQAQVAKMLTKTYRGMLFRRVSESFKHFPSPEELKGKILISTKPPKEYLESKTVHTTRTPTVKETSWNRVANKILEEYKDMESEAVGYRDLIAIHAANCKDPSKDCLSDDPEKPIRVSMDEQWLDTMVRTRGTDLVRFTQRNLVRIYPKGTRVDSSNYDPHVGWTHGAQMVAFNMQGHGKQLWIMQGMFRGNGGCGYVKKPRILLDEHTLFDPCKRFPIKTTLKVKIYTGEGWDLDFHHTHFDQYSPPDFFVKIGIAGVPRDTVSYRTETAVDQWFPIWGNDEFLFQLSVPELALLWFKVQDYDNDTQNDFAGQTCLPLPELKSGVRAVRLHDRTGKAYKNTRLLVSFALDPPYTFR

Gene Information

Entrez Gene ID
830010
Gene Name
putative phosphoinositide phospholipase C 3
Gene Symbol
PLC1
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0005509 IEA:InterPro F calcium ion binding
GO:0004435 IEA:UniProtKB-EC F phosphatidylinositol phospholipase C activity
GO:0004871 IEA:UniProtKB-KW F signal transducer activity
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ath00562 Inositol phosphate metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
6254172 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
6253932 GPVI-mediated activation cascade
6254346 Signaling by FGFR1 fusion mutants

Domain Information

InterPro Annotations

Accession Description
IPR000008 C2 domain
IPR011992 EF-hand domain pair
IPR001192 Phosphoinositide phospholipase C family
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

UniProt Annotations

Entry Information

Gene Name
putative phosphoinositide phospholipase C 3
Protein Entry
PLCD3_ARATH
UniProt ID
Q56W08
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
Cofactor Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. {ECO:0000269|Ref.6}.
Induction Not induced by environmental stresses such as dehydration, salinity and low temperature.
Sequence Caution Sequence=AAC48991.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC48991.1; Type=Frameshift; Positions=535, 543; Evidence={ECO:0000305}; Sequence=CAB37509.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAB80517.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity Contains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Similarity Contains 1 EF-hand domain. {ECO:0000305}.
Similarity Contains 1 PI-PLC X-box domain. {ECO:0000255|PROSITE- ProRule:PRU00270}.
Similarity Contains 1 PI-PLC Y-box domain. {ECO:0000255|PROSITE- ProRule:PRU00271}.
Subcellular Location Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue Specificity Expressed in leaves, roots and siliques, but not in flowers. {ECO:0000269|Ref.6}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010847 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
79499922 RefSeq NP_195565 564 putative phosphoinositide phospholipase C 3

Identical Sequences to LMP010847 proteins

Reference Database Accession Length Protein Name
GI:79499922 GenBank ADS19250.1 564 Sequence 40 from patent US 7763771
GI:79499922 GenBank AEE86943.1 564 putative phosphoinositide phospholipase C 3 [Arabidopsis thaliana]
GI:79499922 GenBank AEF79520.1 564 Sequence 40 from patent US 7943817
GI:79499922 GenBank AFL01307.1 564 Sequence 40 from patent US 8163978
GI:79499922 GenBank AGF20825.1 564 Sequence 40 from patent US 8367892
GI:79499922 SwissProt Q56W08.1 564 RecName: Full=Phosphoinositide phospholipase C 3; AltName: Full=Phosphoinositide phospholipase PLC3; Short=AtPLC1F; Short=AtPLC3; Short=PI-PLC3 [Arabidopsis thaliana]

Related Sequences to LMP010847 proteins

Reference Database Accession Length Protein Name
GI:79499922 EMBL CAB80517.1 526 phosphoinositide-specific phospholipase C [Arabidopsis thaliana]
GI:79499922 EMBL CBF74577.1 526 unnamed protein product [Arabidopsis thaliana]
GI:79499922 EMBL CBU87770.1 526 unnamed protein product [Arabidopsis thaliana]
GI:79499922 EMBL CBU96717.1 526 unnamed protein product [Arabidopsis thaliana]
GI:79499922 GenBank EFH43064.1 575 ATPLC1 [Arabidopsis lyrata subsp. lyrata]
GI:79499922 RefSeq XP_002866805.1 575 ATPLC1 [Arabidopsis lyrata subsp. lyrata]