Gene/Proteome Database (LMPD)

LMPD ID
LMP010849
Gene ID
835983
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
phosphoinositide phospholipase C 5
Gene Symbol
PLC5
Synonyms
ATPLC5; MZN1.15; MZN1_15; phosphatidylinositol-speciwc phospholipase C5; PLC5
Alternate Names
phosphoinositide phospholipase C 5
Chromosome
5
EC Number
3.1.4.11

Proteins

phosphoinositide phospholipase C 5
Refseq ID NP_200677
Protein GI 22327954
UniProt ID Q944C2
mRNA ID NM_125256
Length 578
RefSeq Status REVIEWED
MKRDMGSYKMGLCCSDKLRMNRGAPPQDVVTAFVEYTEGRSHMTAEQLCRFLVEVQDETEVLVSDAEKIIERITCERHHITKFLRHTLNLDDFFSFLFSDDLNHPIDSKVHQDMASPLSHYFIYTSHNSYLTGNQINSECSDVPLIKALKRGVRALELDMWPNSTKDDILVLHGWAWTPPVELVKCLRSIKEHAFYASAYPVILTLEDHLTPDLQAKAAEMMKEIFMDMVYFPEAGGLKEFPSPEDLKYKIVISTKPPKGSLRKDKDSESDASGKASSDVSADDEKTEEETSEAKNEEDGFDQESSNLDFLTYSRLITIPSGNAKNGLKEALTIDNGGVRRLSLREQKFKKATEMYGTEVIKFTQKNLLRIYPKATRVNSSNYRPYNGWMYGAQMVAFNMQGYGRALWMMHGMFRGNGGCGYVKKPDFMMNNNLSGEVFNPKAKLPIKKTLKVKVYMGKGWDSGFQRTCFNTWSSPNFYTRVGITGVRGDKVMKKTKKEQKTWEPFWNEEFEFQLTVPELALLRIEVHDYNMPEKDDFSGQTCLPVSELRQGIRSVPLYDRKGERLVSVTLLMRFHFL

Gene Information

Entrez Gene ID
835983
Gene Name
phosphoinositide phospholipase C 5
Gene Symbol
PLC5
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0005509 IEA:InterPro F calcium ion binding
GO:0004435 IEA:UniProtKB-EC F phosphatidylinositol phospholipase C activity
GO:0004871 IEA:UniProtKB-KW F signal transducer activity
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ath00562 Inositol phosphate metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
6254172 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
6253932 GPVI-mediated activation cascade
6254346 Signaling by FGFR1 fusion mutants

Domain Information

InterPro Annotations

Accession Description
IPR000008 C2 domain
IPR011992 EF-hand domain pair
IPR001192 Phosphoinositide phospholipase C family
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

UniProt Annotations

Entry Information

Gene Name
phosphoinositide phospholipase C 5
Protein Entry
PLCD5_ARATH
UniProt ID
Q944C2
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
Cofactor Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. {ECO:0000269|Ref.6}.
Induction By environmental stresses such as dehydration, salinity and low temperature. {ECO:0000269|Ref.6}.
Sequence Caution Sequence=BAA97337.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity Contains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Similarity Contains 1 EF-hand-like domain. {ECO:0000305}.
Similarity Contains 1 PI-PLC X-box domain. {ECO:0000255|PROSITE- ProRule:PRU00270}.
Similarity Contains 1 PI-PLC Y-box domain. {ECO:0000255|PROSITE- ProRule:PRU00271}.
Subcellular Location Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein.
Tissue Specificity Expressed in leaves, roots, flowers and siliques. High levels of expression in the guard cells and vasculature of leaves and roots. {ECO:0000269|Ref.6}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010849 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
22327954 RefSeq NP_200677 578 phosphoinositide phospholipase C 5

Identical Sequences to LMP010849 proteins

Reference Database Accession Length Protein Name
GI:22327954 EMBL CBF62948.1 578 unnamed protein product [Arabidopsis thaliana]
GI:22327954 EMBL CBU87824.1 578 unnamed protein product [Arabidopsis thaliana]
GI:22327954 EMBL CBU96771.1 578 unnamed protein product [Arabidopsis thaliana]
GI:22327954 GenBank AGX54759.1 578 Sequence 9874 from patent US 8541208
GI:22327954 GenBank AGX64199.1 578 Sequence 28508 from patent US 8541208
GI:22327954 gnl TAIR 578 phosphoinositide phospholipase C 5 [Arabidopsis thaliana]

Related Sequences to LMP010849 proteins

Reference Database Accession Length Protein Name
GI:22327954 EMBL CAW48206.1 909 unnamed protein product [Arabidopsis thaliana]
GI:22327954 EMBL CAW65668.1 909 unnamed protein product [Arabidopsis thaliana]
GI:22327954 EMBL CAW81582.1 909 unnamed protein product [Arabidopsis thaliana]
GI:22327954 EMBL CAW73020.1 909 unnamed protein product [Arabidopsis thaliana]
GI:22327954 EMBL CBC64517.1 909 unnamed protein product [Arabidopsis thaliana]
GI:22327954 EMBL CBC81592.1 909 unnamed protein product [Arabidopsis thaliana]