Gene/Proteome Database (LMPD)

LMPD ID
LMP010852
Gene ID
823882
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
phosphoinositide phospholipase C8
Gene Symbol
PLC8
Synonyms
ATPLC8; phosphatidylinositol-speciwc phospholipase C8; PLC8
Alternate Names
phosphoinositide phospholipase C8
Chromosome
3
EC Number
3.1.4.11

Proteins

phosphoinositide phospholipase C8
Refseq ID NP_190313
Protein GI 15232770
UniProt ID Q9STZ3
mRNA ID NM_114596
Length 531
RefSeq Status REVIEWED
MLVTRRWESHPANSPDLILQFFGNEFHGYGDDMPETLRRLTELLGYEKEEDGAGMNAAKKIAAELNRRKDDIPAFRRLRCLELDQLNEFLFSTKLNPPIGDQVHHDMHAPLSHYFIHTSLNSYFTGNVFGKYSILPIIEALEQGVRVVELDLWPDGRGSICVRPSWNFEKPLKLQECLDSIKEHAFTKCTYPLIITFKDGLKPELQSKATQMIQQTFNHMVYHHDPHSLEVFPSPQQLRNKILISRRPPKELLYANDDDGKVGVRNGVEIRQHPADPNYQSLVSFHVVEPRGMLQNVLTGKANKIQRPGWYETDIISFTQKRFLRTRPQRKLLIYAPYKPQRAWMHGAQLIALSRKEEKEKLWLMQGMFRANGGCGYVKKPDFLLNAGPSGVFYPTVNPVVVKILKVKIYMGDGWIVDFKKRIGRLSKPDLYVRISIAGVPHDENIMKTTVKNNEWTPTWGEEFTFPLTYPDLALISFEVYDYEVSTADAFCGQTCLPVSELIEGIRAVPLYDERGKACSSTMLLTRFKWS

Gene Information

Entrez Gene ID
823882
Gene Name
phosphoinositide phospholipase C8
Gene Symbol
PLC8
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0004435 IEA:UniProtKB-EC F phosphatidylinositol phospholipase C activity
GO:0004871 IEA:UniProtKB-KW F signal transducer activity
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process

REACTOME Pathway Links

REACTOME Pathway ID Description
6254171 Acetylcholine regulates insulin secretion
6254172 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
6253932 GPVI-mediated activation cascade
6254346 Signaling by FGFR1 fusion mutants

Domain Information

InterPro Annotations

Accession Description
IPR000008 C2 domain
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR001192 Phosphoinositide phospholipase C family
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain

UniProt Annotations

Entry Information

Gene Name
phosphoinositide phospholipase C8
Protein Entry
PLCD8_ARATH
UniProt ID
Q9STZ3
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
Caution Contains substitutions of several amino acids thought to be essential for catalytic activity. Its enzyme activity is therefore unsure. {ECO:0000305}.
Cofactor Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. {ECO:0000250}.
Similarity Contains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Similarity Contains 1 PI-PLC X-box domain. {ECO:0000255|PROSITE- ProRule:PRU00270}.
Similarity Contains 1 PI-PLC Y-box domain. {ECO:0000255|PROSITE- ProRule:PRU00271}.
Subcellular Location Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue Specificity Expressed in leaves, roots, flowers and siliques. {ECO:0000269|Ref.6}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010852 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15232770 RefSeq NP_190313 531 phosphoinositide phospholipase C8

Identical Sequences to LMP010852 proteins

Reference Database Accession Length Protein Name
GI:15232770 EMBL CAB51201.1 531 1-phosphatidylinositol-4, 5-bisphosphate phosphodiesterase [Arabidopsis thaliana]
GI:15232770 GenBank AAO42201.1 531 putative 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase [Arabidopsis thaliana]
GI:15232770 GenBank AAO63890.1 531 putative 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase [Arabidopsis thaliana]
GI:15232770 GenBank AEE78261.1 531 phosphoinositide phospholipase C8 [Arabidopsis thaliana]
GI:15232770 GenBank AGD03201.1 531 Sequence 657 from patent US 8343764
GI:15232770 SwissProt Q9STZ3.1 531 RecName: Full=Phosphoinositide phospholipase C 8; AltName: Full=Phosphoinositide phospholipase PLC8; Short=AtPLC8; Short=PI-PLC8 [Arabidopsis thaliana]

Related Sequences to LMP010852 proteins

Reference Database Accession Length Protein Name
GI:15232770 DBBJ BAE98796.1 531 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase-like protein [Arabidopsis thaliana]
GI:15232770 EMBL CAA59962.1 531 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase [Arabidopsis thaliana]
GI:15232770 EMBL CBU87845.1 531 unnamed protein product [Arabidopsis thaliana]
GI:15232770 RefSeq NP_190306.2 531 phosphoinositide phospholipase C9 [Arabidopsis thaliana]
GI:15232770 RefSeq XP_010503332.1 522 PREDICTED: phosphoinositide phospholipase C 9-like [Camelina sativa]
GI:15232770 RefSeq XP_010426172.1 522 PREDICTED: phosphoinositide phospholipase C 9-like [Camelina sativa]