Gene/Proteome Database (LMPD)
Proteins
| 3-oxo-5-alpha-steroid 4-dehydrogenase family protein | |
|---|---|
| Refseq ID | NP_177403 |
| Protein GI | 15218532 |
| UniProt ID | Q9CAH5 |
| mRNA ID | NM_105918 |
| Length | 320 |
| RefSeq Status | REVIEWED |
| MEVEIVWLVKAAWITVWIVSILPLVIASIPSSKLNSFRELVLSFAGRGKILHPSSQKFTVPQKFFGHFYVVGVVWTTLLLAATWMYACKMAGGSHVFSFHMTHVEHRFKVGRAVFLLLLMEIHVLRRVIESFYVFKYSTSARMHILAYVGALFYYVAAPLSLCSNIAPEVARFVGSQVAEFIASGKSHSHDFNLLLSISPLMKLGSLQWIGGAIFLWGWIHQRRCHAILGSLREYPSQAKEYIIPYGDWFEMVSCPHFLAEIVLYLGLLISSGGTDISIWLLFGFVAANLTYAAGETHRWYLQKFENYPASRHAIFPHVY | |
Gene Information
Entrez Gene ID
Gene Name
3-oxo-5-alpha-steroid 4-dehydrogenase family protein
Gene Symbol
Species
Arabidopsis thaliana
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005783 | IEA:UniProtKB-KW | C | endoplasmic reticulum |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0016627 | IEA:InterPro | F | oxidoreductase activity, acting on the CH-CH group of donors |
| GO:0006629 | IEA:InterPro | P | lipid metabolic process |
| GO:0006486 | IEA:UniProtKB-UniPathway | P | protein glycosylation |
REACTOME Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR001104 | 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal |
UniProt Annotations
Entry Information
Gene Name
3-oxo-5-alpha-steroid 4-dehydrogenase family protein
Protein Entry
POED1_ARATH
UniProt ID
Species
Arabidopsis
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Ditrans,polycis-dolichol + NADP(+) = ditrans,polycis-polyprenol + NADPH. |
| Function | Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism (By similarity). {ECO:0000250}. |
| Pathway | Protein modification; protein glycosylation. |
| Similarity | Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily. {ECO:0000305}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP010940 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 15218532 | RefSeq | NP_177403 | 320 | 3-oxo-5-alpha-steroid 4-dehydrogenase family protein |
Identical Sequences to LMP010940 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:15218532 | GenBank | AAG51854.1 | 320 | unknown protein; 74916-73528 [Arabidopsis thaliana] |
| GI:15218532 | GenBank | ADT60275.1 | 320 | Sequence 1440 from patent US 7847156 |
| GI:15218532 | GenBank | AEE35345.1 | 320 | 3-oxo-5-alpha-steroid 4-dehydrogenase family protein [Arabidopsis thaliana] |
| GI:15218532 | SwissProt | Q9CAH5.1 | 320 | RecName: Full=Polyprenol reductase 1 [Arabidopsis thaliana] |
Related Sequences to LMP010940 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:15218532 | GenBank | EFH49022.1 | 342 | 3-oxo-5-alpha-steroid 4-dehydrogenase family protein [Arabidopsis lyrata subsp. lyrata] |
| GI:15218532 | GenBank | EFH62315.1 | 342 | 3-oxo-5-alpha-steroid 4-dehydrogenase family protein [Arabidopsis lyrata subsp. lyrata] |
| GI:15218532 | gnl | TIGR | 343 | expressed protein [Arabidopsis thaliana] |
| GI:15218532 | RefSeq | NP_565389.1 | 343 | putative polyprenol reductase 2 [Arabidopsis thaliana] |
| GI:15218532 | RefSeq | XP_002872763.1 | 342 | 3-oxo-5-alpha-steroid 4-dehydrogenase family protein [Arabidopsis lyrata subsp. lyrata] |
| GI:15218532 | RefSeq | XP_002886056.1 | 342 | 3-oxo-5-alpha-steroid 4-dehydrogenase family protein [Arabidopsis lyrata subsp. lyrata] |