Gene/Proteome Database (LMPD)
Proteins
| 3-deoxy-D-manno-octulosonic-acid transferase | |
|---|---|
| Refseq ID | NP_195997 |
| Protein GI | 22326592 |
| UniProt ID | Q8VZA5 |
| mRNA ID | NM_120458 |
| Length | 447 |
| RefSeq Status | REVIEWED |
| MKLGVFVYRLYRALTYGVSPLIHLHIRWRRLRGLEHFSRWPERFGHPSAVRPPGSLIWFHAVSLGEGMAAIPVIRHCNEVKSDLTILMTTTTVSAFEVIKNQLPVGVLHQFAPLDTPLAIDRFLGHWKPNAIIIMENELWPNLIMAASGLLIPLGLLNARMSTKSFKRWSSPLLLPLVSLLLSKFSLIAPLSTLQGIRFQLLHAPPFVINYSGDLKYVVNKFHVSSGTSESIRDLKVELAEMKVWIASSLHRGEEEVILGVHNMLLESHPDSVVIIVPRHPHHGQQIAHKLRKDGQSVALRSQNEKLTPRKTNIYVVDTLGELRELYSVAPIAVIGGSFIPGLTGHNLSEAAAAGCAVITGCHVGHFSHMVKAMQQANPLSVTQVSTKLELKEAVDLLLSNPEILETHQRASKDVYESLSSCIITNIWKLLNLHIFRGKSRNHIECK | |
Gene Information
Entrez Gene ID
Gene Name
3-deoxy-D-manno-octulosonic-acid transferase
Gene Symbol
Species
Arabidopsis thaliana
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005739 | IEA:UniProtKB-KW | C | mitochondrion |
| GO:0016757 | IEA:UniProtKB-KW | F | transferase activity, transferring glycosyl groups |
| GO:0036104 | IEA:UniProtKB-UniPathway | P | Kdo2-lipid A biosynthetic process |
| GO:0009245 | IEA:UniProtKB-KW | P | lipid A biosynthetic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ath01100 | Metabolic pathways |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| KDOSYN-PWY | KDO transfer to lipid IVA I |
| KDO-NAGLIPASYN-PWY | superpathway of (KDO)2-lipid A biosynthesis |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR007507 | 3-deoxy-D-manno-octulosonic-acid transferase, N-terminal |
UniProt Annotations
Entry Information
Gene Name
3-deoxy-D-manno-octulosonic-acid transferase
Protein Entry
KDTA_ARATH
UniProt ID
Species
Arabidopsis
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Alpha-Kdo-(2->6)-lipid IV(A) + CMP-alpha-Kdo = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IV(A) + CMP. |
| Catalytic Activity | Lipid IV(A) + CMP-alpha-Kdo = alpha-Kdo- (2->6)-lipid IV(A) + CMP. |
| Disruption Phenotype | No visible phenotype under normal growth conditions, but plants lacking KDTA accumulate high levels of tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). {ECO:0000269|PubMed:20124190, ECO:0000269|PubMed:21709257}. |
| Function | Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell. Catalyzes the transfer of two 3-deoxy-D-manno-octulosonate (Kdo) residues from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'- bisphosphate precursor of lipid A. Lipid A-like molecules in plants may serve as structural components of the outer membranes of mitochondria and/or chloroplasts, or may be involved in signal transduction or plant defense responses (Potential). {ECO:0000305}. |
| Pathway | Glycolipid biosynthesis; KDO(2)-lipid A biosynthesis; KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 1/4. {ECO:0000269|PubMed:21709257}. |
| Pathway | Glycolipid biosynthesis; KDO(2)-lipid A biosynthesis; KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 2/4. {ECO:0000269|PubMed:21709257}. |
| Sequence Caution | Sequence=BAB08602.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAB82942.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; |
| Similarity | Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 30 subfamily. {ECO:0000305}. |
| Subcellular Location | Mitochondrion {ECO:0000269|PubMed:20124190}. |
| Tissue Specificity | Expressed in leaves, stems and flowers. {ECO:0000269|PubMed:20124190}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP010946 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 22326592 | RefSeq | NP_195997 | 447 | 3-deoxy-D-manno-octulosonic-acid transferase |
Identical Sequences to LMP010946 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:22326592 | GenBank | AAL38291.1 | 447 | 3-deoxy-D-manno-octulosonic acid transferase-like protein [Arabidopsis thaliana] |
| GI:22326592 | GenBank | AAM91158.1 | 447 | 3-deoxy-D-manno-octulosonic acid transferase-like protein [Arabidopsis thaliana] |
| GI:22326592 | GenBank | AHL38648.1 | 447 | glycosyltransferase, partial [Arabidopsis thaliana] |
| GI:22326592 | gnl | TAIR | 447 | 3-deoxy-D-manno-octulosonic-acid transferase [Arabidopsis thaliana] |
| GI:22326592 | SwissProt | Q8VZA5.1 | 447 | RecName: Full=Probable 3-deoxy-D-manno-octulosonic acid transferase, mitochondrial; Short=AtKdtA; Short=Kdo transferase A; AltName: Full=Bifunctional Kdo transferase; AltName: Full=Kdo-lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase; AltName: Full=Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase; Flags: Precursor [Arabidopsis thaliana] |
Related Sequences to LMP010946 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:22326592 | DBBJ | BAB08602.1 | 440 | 3-deoxy-D-manno-octulosonic acid transferase-like protein [Arabidopsis thaliana] |
| GI:22326592 | EMBL | CAB82942.1 | 481 | 3-deoxy-D-manno-octulosonic acid transferase-like protein [Arabidopsis thaliana] |
| GI:22326592 | GenBank | EFH47316.1 | 439 | hypothetical protein ARALYDRAFT_325028 [Arabidopsis lyrata subsp. lyrata] |
| GI:22326592 | GenBank | EOA20627.1 | 450 | hypothetical protein CARUB_v10000940mg [Capsella rubella] |
| GI:22326592 | RefSeq | XP_002871057.1 | 439 | hypothetical protein ARALYDRAFT_325028 [Arabidopsis lyrata subsp. lyrata] |
| GI:22326592 | RefSeq | XP_006287729.1 | 450 | hypothetical protein CARUB_v10000940mg [Capsella rubella] |