Gene/Proteome Database (LMPD)

LMPD ID
LMP010948
Gene ID
829602
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
3-ketoacyl-CoA synthase 17
Gene Symbol
KCS17
Synonyms
3-ketoacyl-CoA synthase 17; KCS17; T4L20.90; T4L20_90
Alternate Names
3-ketoacyl-CoA synthase 17
Chromosome
4
EC Number
2.3.1.119
Summary
Encodes KCS17, a member of the 3-ketoacyl-CoA synthase family involved in the biosynthesis of VLCFA (very long chain fatty acids).
Orthologs
View orthologs and multiple alignments for KCS17

Proteins

3-ketoacyl-CoA synthase 17
Refseq ID NP_195177
Protein GI 15236133
UniProt ID O65677
mRNA ID NM_119616
Length 487
RefSeq Status REVIEWED
MDANGGPVQIRTQNYVKLGYHYLITHFFKLMFLPLMAVLFMNVSLLSLNHLQLYYNSTGFIFVITLAIVGSIVFFMSRPRSIYLLDYSCYLPPSSQKVSYQKFMNNSSLIQDFSETSLEFQRKILIRSGLGEETYLPDSIHSIPPRPTMAAAREEAEQVIFGALDNLFENTKINPREIGVLVVNCSLFNPTPSLSAMIVNKYKLRGNIKSFNLGGMGCSAGVIAVDLASDMLQIHRNTFALVVSTENITQNWYFGNKKAMLIPNCLFRVGGSAVLLSNKPLDRKRSKYKLVHTVRTHKGSDENAFNCVYQEQDECLKTGVSLSKDLMAIAGEALKTNITSLGPLVLPISEQILFFATFVAKRLFNDKKKKPYIPDFKLALDHFCIHAGGRAVIDELEKSLKLSPKHVEASRMTLHRFGNTSSSSIWYELAYTEAKGRMRKGNRVWQIAFGSGFKCNSAVWVALRNVEPSVNNPWEHCIHRYPVKIDL

Gene Information

Entrez Gene ID
829602
Gene Name
3-ketoacyl-CoA synthase 17
Gene Symbol
KCS17
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0033807 IEA:UniProtKB-EC F icosanoyl-CoA synthase activity
GO:0006633 IEA:UniProtKB-UniPathway P fatty acid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ath01110 Biosynthesis of secondary metabolites
ath_M00415 Fatty acid biosynthesis, elongation, endoplasmic reticulum
ath00062 Fatty acid elongation

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-5080 very long chain fatty acid biosynthesis I

Domain Information

InterPro Annotations

Accession Description
IPR013747 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C-terminal
IPR013601 FAE1/Type III polyketide synthase-like protein
IPR016039 Thiolase-like
IPR016038 Thiolase-like, subgroup
IPR012392 Very-long-chain 3-ketoacyl-CoA synthase

UniProt Annotations

Entry Information

Gene Name
3-ketoacyl-CoA synthase 17
Protein Entry
KCS2_ARATH
UniProt ID
O65677
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO(2).
Catalytic Activity Stearoyl-CoA + malonyl-CoA + 2 NAD(P)H = icosanoyl-CoA + CO(2) + CoA + 2 NAD(P)(+) + H(2)O.
Enzyme Regulation Inhibited by K3 herbicides such as alachlor, allidochlor, anilofos, cafenstrole, fentrazamide and flufenacet. {ECO:0000269|PubMed:15277688}.
Function Active on saturated acyl-CoAs up to C22. Mediates the synthesis of VLCFAs from 20 to 26 carbons in length (e.g. C20:1, C20, C24, C26). {ECO:0000269|PubMed:15277688, ECO:0000269|PubMed:16765910}.
Induction Repressed by herbicides such as flufenacet and benfuresate. {ECO:0000269|PubMed:12916765}.
Pathway Lipid metabolism; fatty acid biosynthesis.
Similarity Belongs to the chalcone/stilbene synthases family. {ECO:0000305}.
Similarity Contains 1 FAE (fatty acid elongase) domain. {ECO:0000305}.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010948 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15236133 RefSeq NP_195177 487 3-ketoacyl-CoA synthase 17

Identical Sequences to LMP010948 proteins

Reference Database Accession Length Protein Name
GI:15236133 EMBL CAA18830.1 487 putative ketoacyl-CoA synthase [Arabidopsis thaliana]
GI:15236133 EMBL CAB80168.1 487 putative ketoacyl-CoA synthase [Arabidopsis thaliana]
GI:15236133 GenBank ACW92370.1 487 Sequence 10850 from patent US 7569389
GI:15236133 GenBank AEE86387.1 487 3-ketoacyl-CoA synthase 17 [Arabidopsis thaliana]
GI:15236133 SwissProt O65677.1 487 RecName: Full=Probable 3-ketoacyl-CoA synthase 2; Short=KCS-2; AltName: Full=Very long-chain fatty acid condensing enzyme 2; Short=VLCFA condensing enzyme 2 [Arabidopsis thaliana]

Related Sequences to LMP010948 proteins

Reference Database Accession Length Protein Name
GI:15236133 GenBank EFH45402.1 487 3-ketoacyl-CoA synthase 2 [Arabidopsis lyrata subsp. lyrata]
GI:15236133 GenBank EOA17814.1 481 hypothetical protein CARUB_v10006212mg [Capsella rubella]
GI:15236133 RefSeq XP_002869143.1 487 3-ketoacyl-CoA synthase 2 [Arabidopsis lyrata subsp. lyrata]
GI:15236133 RefSeq XP_006284916.1 481 hypothetical protein CARUB_v10006212mg [Capsella rubella]
GI:15236133 RefSeq XP_010432405.1 477 PREDICTED: probable 3-ketoacyl-CoA synthase 2 [Camelina sativa]
GI:15236133 RefSeq XP_010447067.1 481 PREDICTED: probable 3-ketoacyl-CoA synthase 2 [Camelina sativa]