Gene/Proteome Database (LMPD)

LMPD ID
LMP010955
Gene ID
841977
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
acyl-activating enzyme 18
Gene Symbol
AAE18
Synonyms
acyl-activating enzyme 18; F7A10.14; F7A10_14
Alternate Names
acyl-activating enzyme 18
Chromosome
1
EC Number
6.2.1.-
Summary
Encodes a protein with similarity to acyl activating enzymes. AAE18 is localized to the peroxisome where it may be involved in metabolism of auxin precursors to active auxins.
Orthologs
View orthologs and multiple alignments for AAE18

Proteins

acyl-activating enzyme 18
Refseq ID NP_001077723
Protein GI 145325437
UniProt ID Q84P17
mRNA ID NM_001084254
Length 511
RefSeq Status REVIEWED
MLVANAISGSFEKGDTIAIDMPMTVDAVIIYLAIILAGCIVVSIADSFAAKEIATRLKISKAKGIFTQDYILRGGRRFPLYSRVVEAAPSKVIVLPASGTELHVQLREQDVSWMDFLSNAKPHSSGENYYRPIYLPVESVINILFSSGTTGEPKAIPWTQLSPIRSACDGWAHLDVQVGHTYCWPTNLGWVMGPTLMFSCFLTGATLALYSGSPLGRGFGKFVQDAGVTVLGTVPSLVKTWKRTNCMEGLNWTKIKFFATTGEASNVDDVLWLSSKADYKPVIECCGGTELASSYIIGSPLQPQAFGAFSTPSMTTRIIIFDENGVPYPDDQPCTGEVGLFPQHLGATDRLLNANHDEVYFKGMPMYKETRLRRHGDIVKRTVGGYYNVQGRADDTMNLGGIKTSSIEIERVCDQADECISETAAVTLTPPNGGPELLVIFAVLKEGFKQQSGEELKMKFSRTIQKDLNPLFKVSFVKIVPEFPRTASSKLLRRVLRDQIKQELLSLRSRI
acyl-activating enzyme 18
Refseq ID NP_175929
Protein GI 145336784
UniProt ID Q84P17
mRNA ID NM_104408
Length 727
RefSeq Status REVIEWED
MWKSIGELSCDDYVKAGLTLEDAKEFDKLVSDVITKAIETDPRDQWKALVDESVLKPWHPHPLHQLLYYSVYSNWDSSVHGPPLYWFPSLSQSKSTNLGKLMEYHGPRLLGPSYKNPLESFELFRRFSVEHPEVYWSFVIDELSLVFHTPPRCILNKSKPEGTWLPDAVLNIAECCLMPSSHPKKEDDSVAVVWRNEGFDDSPVNRMTIKELREQVMLVANAISGSFEKGDTIAIDMPMTVDAVIIYLAIILAGCIVVSIADSFAAKEIATRLKISKAKGIFTQDYILRGGRRFPLYSRVVEAAPSKVIVLPASGTELHVQLREQDVSWMDFLSNAKPHSSGENYYRPIYLPVESVINILFSSGTTGEPKAIPWTQLSPIRSACDGWAHLDVQVGHTYCWPTNLGWVMGPTLMFSCFLTGATLALYSGSPLGRGFGKFVQDAGVTVLGTVPSLVKTWKRTNCMEGLNWTKIKFFATTGEASNVDDVLWLSSKADYKPVIECCGGTELASSYIIGSPLQPQAFGAFSTPSMTTRIIIFDENGVPYPDDQPCTGEVGLFPQHLGATDRLLNANHDEVYFKGMPMYKETRLRRHGDIVKRTVGGYYNVQGRADDTMNLGGIKTSSIEIERVCDQADECISETAAVTLTPPNGGPELLVIFAVLKEGFKQQSGEELKMKFSRTIQKDLNPLFKVSFVKIVPEFPRTASSKLLRRVLRDQIKQELLSLRSRI

Gene Information

Entrez Gene ID
841977
Gene Name
acyl-activating enzyme 18
Gene Symbol
AAE18
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005777 IDA:TAIR C peroxisome
GO:0016874 IEA:UniProtKB-KW F ligase activity
GO:0009850 IMP:TAIR P auxin metabolic process
GO:0006631 IEA:UniProtKB-KW P fatty acid metabolic process

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY0-1313 acetate conversion to acetyl-CoA
PWY66-21 ethanol degradation II
PWY66-162 ethanol degradation IV

Domain Information

InterPro Annotations

Accession Description
IPR020845 AMP-binding, conserved site
IPR000873 AMP-dependent synthetase/ligase

UniProt Annotations

Entry Information

Gene Name
acyl-activating enzyme 18
Protein Entry
AEE18_ARATH
UniProt ID
Q84P17
Species
Arabidopsis

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q84P17-1; Sequence=Displayed; Name=2; IsoId=Q84P17-2; Sequence=VSP_042325; Note=No experimental confirmation available.;
Disruption Phenotype No visible phenotype under normal growth conditions, but plants are resistant to 2,4-DB. {ECO:0000269|PubMed:19043666}.
Function May be involved in the peroxisomal activation of 2,4- dichlorophenoxybutyric acid (2,4-DB), a precursor of active auxins that inhibit root growth. {ECO:0000269|PubMed:19043666}.
Sequence Caution Sequence=AAG51574.1; Type=Erroneous gene model prediction; Note=The predicted gene At1g55325 has been split into 2 genes: At1g55320 and At1g55325.; Evidence={ECO:0000305};
Similarity Belongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.
Subcellular Location Peroxisome {ECO:0000269|PubMed:19043666}.
Tissue Specificity Expressed in flowers. {ECO:0000269|PubMed:12805634}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010955 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
145336784 RefSeq NP_175929 727 acyl-activating enzyme 18
145325437 RefSeq NP_001077723 511 acyl-activating enzyme 18

Identical Sequences to LMP010955 proteins

Reference Database Accession Length Protein Name
GI:145336784 GenBank AAP03028.1 727 acyl-activating enzyme 18 [Arabidopsis thaliana]
GI:145336784 GenBank AEE33225.1 727 acyl-activating enzyme 18 [Arabidopsis thaliana]
GI:145325437 GenBank AEE33226.1 511 acyl-activating enzyme 18 [Arabidopsis thaliana]
GI:145336784 SwissProt Q84P17.1 727 RecName: Full=Probable acyl-activating enzyme 18, peroxisomal [Arabidopsis thaliana]

Related Sequences to LMP010955 proteins

Reference Database Accession Length Protein Name
GI:145336784 GenBank AAG51574.1 2655 acetyl-CoA synthetase, putative; 45051-31547 [Arabidopsis thaliana]
GI:145325437 GenBank AAG51574.1 2655 acetyl-CoA synthetase, putative; 45051-31547 [Arabidopsis thaliana]
GI:145325437 GenBank AAP03028.1 727 acyl-activating enzyme 18 [Arabidopsis thaliana]
GI:145325437 GenBank AEE33225.1 727 acyl-activating enzyme 18 [Arabidopsis thaliana]
GI:145336784 GenBank EOA37633.1 727 hypothetical protein CARUB_v10012089mg [Capsella rubella]
GI:145325437 RefSeq NP_175929.3 727 acyl-activating enzyme 18 [Arabidopsis thaliana]
GI:145336784 RefSeq XP_006304735.1 727 hypothetical protein CARUB_v10012089mg [Capsella rubella]
GI:145336784 RefSeq XP_010501144.1 724 PREDICTED: probable acyl-activating enzyme 18, peroxisomal [Camelina sativa]
GI:145336784 RefSeq XP_010462380.1 728 PREDICTED: probable acyl-activating enzyme 18, peroxisomal [Camelina sativa]
GI:145325437 RefSeq XP_010462380.1 728 PREDICTED: probable acyl-activating enzyme 18, peroxisomal [Camelina sativa]
GI:145336784 RefSeq XP_010480067.1 724 PREDICTED: probable acyl-activating enzyme 18, peroxisomal [Camelina sativa]
GI:145325437 SwissProt Q84P17.1 727 RecName: Full=Probable acyl-activating enzyme 18, peroxisomal [Arabidopsis thaliana]