Gene/Proteome Database (LMPD)

LMPD ID
LMP010982
Gene ID
828140
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
bifunctional sn-glycerol-3-phosphate 2-O-acyltransferase/phosphatase
Gene Symbol
GPAT8
Synonyms
AtGPAT8; A_IG005I10.4; A_IG005I10_4; F5I10.4; F5I10_4; glycerol-3-phosphate acyltransferase 8; GPAT8
Alternate Names
bifunctional sn-glycerol-3-phosphate 2-O-acyltransferase/phosphatase
Chromosome
4
EC Number
2.3.1.15
Summary
Involved in cutin assembly. Is functionally redundant with GPAT4.
Orthologs
View orthologs and multiple alignments for GPAT8

Proteins

bifunctional sn-glycerol-3-phosphate 2-O-acyltransferase/phosphatase
Refseq ID NP_191950
Protein GI 42566190
UniProt ID Q5XF03
mRNA ID NM_116264
Length 500
RefSeq Status REVIEWED
MSPEKKSQNFPPITECRDGEYDSIAADLDGTLLLSRSSFPYFMLVAVEAGSLLRGLILLLSLPFVIISYLFVSESLGIQILIFISFAGLKIRDIELVSRAVLPRFYAADVRKDSFEVFDKCKRKVVVTANPIVMVEAFVKDYLGGDKVLGTEIEVNPKTNRATGFVKKPGVLVGDLKRLAILKEFGNESPDLGLGDRTSDHDFMSLCKKGYMVHATKSATTIPKERLKNRIVFHDGRLAQRPTPLNAIITYLWLPFGFILSIIRVYFNLPLPERFVRYTYEMLGIHLTIRGHRPPPPSPGTLGNLYVLNHRTALDPIIVAIALGRKICCVTYSVSRLSLMLSPIPAVALTRDRATDAANMRKLLEKGDLVICPEGTTCREEYLLRFSALFAELSDRIVPVAMNCKQGMFNGTTVRGVKFWDPYFFFMNPRPSYEATFLDRLPEEMTVNGGGKTPIEVANYVQKVIGAVLGFECTELTRKDKYLLLGGNDGKVESINNTKK

Gene Information

Entrez Gene ID
828140
Gene Name
bifunctional sn-glycerol-3-phosphate 2-O-acyltransferase/phosphatase
Gene Symbol
GPAT8
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:TAIR C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0090447 IDA:TAIR F glycerol-3-phosphate 2-O-acyltransferase activity
GO:0004366 IEA:UniProtKB-EC F glycerol-3-phosphate O-acyltransferase activity
GO:0016791 IDA:TAIR F phosphatase activity
GO:0016024 IEA:UniProtKB-UniPathway P CDP-diacylglycerol biosynthetic process
GO:0010143 IMP:TAIR P cutin biosynthetic process
GO:0016311 IDA:GOC P dephosphorylation

KEGG Pathway Links

KEGG Pathway ID Description
ath00561 Glycerolipid metabolism
ath00564 Glycerophospholipid metabolism
ath01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR002123 Phospholipid/glycerol acyltransferase

UniProt Annotations

Entry Information

Gene Name
bifunctional sn-glycerol-3-phosphate 2-O-acyltransferase/phosphatase
Protein Entry
GPAT8_ARATH
UniProt ID
Q5XF03
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1- acyl-sn-glycerol 3-phosphate.
Domain The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. {ECO:0000250}.
Function Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. {ECO:0000250}.
Pathway Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3.
Sequence Caution Sequence=AAB62826.1; Type=Erroneous gene model prediction; Note=Was originally thought to correspond to two different genes At4g00400 and At4g00410.; Evidence={ECO:0000305}; Sequence=AAB62827.1; Type=Erroneous gene model prediction; Note=Was originally thought to correspond to two different genes At4g00400 and At4g00410.; Evidence={ECO:0000305}; Sequence=AAF02784.1; Type=Erroneous gene model prediction; Note=Was originally thought to correspond to two different genes At4g00400 and At4g00410.; Evidence={ECO:0000305}; Sequence=AAF02785.1; Type=Erroneous gene model prediction; Note=Was originally thought to correspond to two different genes At4g00400 and At4g00410.; Evidence={ECO:0000305}; Sequence=CAB80798.1; Type=Erroneous gene model prediction; Note=Was originally thought to correspond to two different genes At4g00400 and At4g00410.; Evidence={ECO:0000305}; Sequence=CAB80799.1; Type=Erroneous gene model prediction; Note=Was originally thought to correspond to two different genes At4g00400 and At4g00410.; Evidence={ECO:0000305};
Similarity Belongs to the GPAT/DAPAT family. {ECO:0000305}.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010982 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
42566190 RefSeq NP_191950 500 bifunctional sn-glycerol-3-phosphate 2-O-acyltransferase/phosphatase

Identical Sequences to LMP010982 proteins

Reference Database Accession Length Protein Name
GI:42566190 GenBank AAU94376.1 500 At4g00400 [Arabidopsis thaliana]
GI:42566190 GenBank ACX17196.1 500 Sequence 44589 from patent US 7569389
GI:42566190 GenBank AEE81873.1 500 bifunctional sn-glycerol-3-phosphate 2-O-acyltransferase/phosphatase [Arabidopsis thaliana]
GI:42566190 SwissProt Q5XF03.1 500 RecName: Full=Probable glycerol-3-phosphate acyltransferase 8 [Arabidopsis thaliana]

Related Sequences to LMP010982 proteins

Reference Database Accession Length Protein Name
GI:42566190 DBBJ BAF00762.1 500 hypothetical protein [Arabidopsis thaliana]
GI:42566190 GenBank EFH49214.1 498 phospholipid/glycerol acyltransferase family protein [Arabidopsis lyrata subsp. lyrata]
GI:42566190 RefSeq XP_002872955.1 498 phospholipid/glycerol acyltransferase family protein [Arabidopsis lyrata subsp. lyrata]
GI:42566190 RefSeq XP_010427002.1 502 PREDICTED: probable glycerol-3-phosphate acyltransferase 8 isoform X2 [Camelina sativa]
GI:42566190 RefSeq XP_010419580.1 502 PREDICTED: probable glycerol-3-phosphate acyltransferase 8 [Camelina sativa]
GI:42566190 RefSeq XP_010456291.1 502 PREDICTED: probable glycerol-3-phosphate acyltransferase 8 [Camelina sativa]