Gene/Proteome Database (LMPD)
Proteins
| probable lipid-A-disaccharide synthase | |
|---|---|
| Refseq ID | NP_178535 |
| Protein GI | 334184140 |
| UniProt ID | W8Q740 |
| mRNA ID | NM_126487 |
| Length | 460 |
| RefSeq Status | REVIEWED |
| MMFQITKSKLRFPLSTFTKRYSSFQAAKSVIDKAAIDGELRVFIVSGEVSGDNIGSRLMSSLKKLSPLPIRFNGVGGSLMCKKGLNSLFPMEDLAVMGVWELLPHLYKFRVKLKETIDAAVKFKPHVVVTVDSKGFSFRLLKELRARYKQQRLENCSVHFHYVAPSFWAWKGGESRLGGLSEFVDHLFCILPNEERVCREHGVEATFVGHPVLEDASEFDLVRRCKPQELKLEGLSFSEHSIPSDSTVISVLPGSRLQEVERMLPIFSKAMKLLKDPFPKLVTLIHVASNNQVDHYIGESFSEWPVPAILVPSGSTQLKYDAFGASQAALCTSGTVAVELQLAHLPSLVAYRAHFLTELLIRYKAKIPYISLPNILLDSPIIPEALFQACNPSNLASILERLLLDEKMRERQVVGAEKLIQLLHPSESRMGNSIHCTGLESHRYTPSILAASTILSYARR | |
Gene Information
Entrez Gene ID
Gene Name
probable lipid-A-disaccharide synthase
Gene Symbol
Species
Arabidopsis thaliana
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005739 | IMP:UniProtKB | C | mitochondrion |
| GO:0008915 | IMP:UniProtKB | F | lipid-A-disaccharide synthase activity |
| GO:0009245 | IEA:UniProtKB-KW | P | lipid A biosynthetic process |
| GO:2001289 | IMP:UniProtKB | P | lipid X metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ath01100 | Metabolic pathways |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR003835 | Glycosyl transferase, family 19 |
UniProt Annotations
Entry Information
Gene Name
probable lipid-A-disaccharide synthase
Protein Entry
LPXB_ARATH
UniProt ID
Species
Arabidopsis
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D- 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. |
| Disruption Phenotype | No visible phenotype under normal growth conditions, but plants lacking LPXB accumulate high levels of 2,3- diacylglucosamine-1-phosphate and UDP-2,3-diacylglucosamine. {ECO:0000269|PubMed:21709257}. |
| Function | Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that in bacteria anchors the lipopolysaccharide to the outer membrane of the cell. Lipid A-like molecules in plants may serve as structural components of the outer membranes of mitochondria and/or chloroplasts, or may be involved in signal transduction or plant defense responses (Potential). {ECO:0000305}. |
| Pathway | Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. {ECO:0000269|PubMed:21709257}. |
| Sequence Caution | Sequence=AAD25824.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAY34177.1; Type=Frameshift; Positions=146; Evidence={ECO:0000305}; |
| Similarity | Belongs to the LpxB family. {ECO:0000305}. |
| Subcellular Location | Mitochondrion {ECO:0000269|PubMed:21709257}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP010994 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 334184140 | RefSeq | NP_178535 | 460 | probable lipid-A-disaccharide synthase |
Identical Sequences to LMP010994 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:334184140 | GenBank | AEC05847.1 | 460 | probable lipid-A-disaccharide synthase [Arabidopsis thaliana] |
| GI:334184140 | GenBank | AHL38859.1 | 460 | glycosyltransferase, partial [Arabidopsis thaliana] |
| GI:334184140 | SwissProt | F4IF99.1 | 460 | RecName: Full=Probable lipid-A-disaccharide synthase, mitochondrial; AltName: Full=Protein LIPID X B; Short=AtLpxB; Flags: Precursor [Arabidopsis thaliana] |
Related Sequences to LMP010994 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:334184140 | GenBank | EFH62020.1 | 454 | hypothetical protein ARALYDRAFT_480096 [Arabidopsis lyrata subsp. lyrata] |
| GI:334184140 | GenBank | EOA32809.1 | 461 | hypothetical protein CARUB_v10016120mg [Capsella rubella] |
| GI:334184140 | RefSeq | XP_002885761.1 | 454 | hypothetical protein ARALYDRAFT_480096 [Arabidopsis lyrata subsp. lyrata] |
| GI:334184140 | RefSeq | XP_006299911.1 | 461 | hypothetical protein CARUB_v10016120mg [Capsella rubella] |
| GI:334184140 | RefSeq | XP_010514635.1 | 460 | PREDICTED: probable lipid-A-disaccharide synthase, mitochondrial [Camelina sativa] |
| GI:334184140 | RefSeq | XP_010467008.1 | 460 | PREDICTED: probable lipid-A-disaccharide synthase, mitochondrial [Camelina sativa] |