Gene/Proteome Database (LMPD)

LMPD ID
LMP011228
Gene ID
839429
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
pyruvate dehydrogenase E1 alpha subunit
Gene Symbol
PDH-E1 ALPHA
Synonyms
pyruvate dehydrogenase E1 alpha; T25K16.8; T25K16_8
Alternate Names
pyruvate dehydrogenase E1 alpha subunit
Chromosome
1
EC Number
1.2.4.1
Summary
pyruvate dehydrogenase E1 alpha subunit
Orthologs
View orthologs and multiple alignments for PDH-E1 ALPHA

Proteins

pyruvate dehydrogenase E1 alpha subunit
Refseq ID NP_171617
Protein GI 15223294
UniProt ID O24457
mRNA ID NM_099991
Length 428
RefSeq Status REVIEWED
MATAFAPTKLTATVPLHGSHENRLLLPIRLAPPSSFLGSTRSLSLRRLNHSNATRRSPVVSVQEVVKEKQSTNNTSLLITKEEGLELYEDMILGRSFEDMCAQMYYRGKMFGFVHLYNGQEAVSTGFIKLLTKSDSVVSTYRDHVHALSKGVSARAVMSELFGKVTGCCRGQGGSMHMFSKEHNMLGGFAFIGEGIPVATGAAFSSKYRREVLKQDCDDVTVAFFGDGTCNNGQFFECLNMAALYKLPIIFVVENNLWAIGMSHLRATSDPEIWKKGPAFGMPGVHVDGMDVLKVREVAKEAVTRARRGEGPTLVECETYRFRGHSLADPDELRDAAEKAKYAARDPIAALKKYLIENKLAKEAELKSIEKKIDELVEEAVEFADASPQPGRSQLLENVFADPKGFGIGPDGRYRCEDPKFTEGTAQV

Gene Information

Entrez Gene ID
839429
Gene Name
pyruvate dehydrogenase E1 alpha subunit
Gene Symbol
PDH-E1 ALPHA
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009507 IDA:TAIR C chloroplast
GO:0009941 IDA:TAIR C chloroplast envelope
GO:0009570 IDA:TAIR C chloroplast stroma
GO:0004739 IEA:UniProtKB-EC F pyruvate dehydrogenase (acetyl-transferring) activity
GO:0006096 IEA:UniProtKB-KW P glycolytic process

KEGG Pathway Links

KEGG Pathway ID Description
ath01200 Carbon metabolism
ath00020 Citrate cycle (TCA cycle)
ath00010 Glycolysis / Gluconeogenesis
ath_M00307 Pyruvate oxidation, pyruvate => acetyl-CoA

Domain Information

InterPro Annotations

Accession Description
IPR001017 Dehydrogenase, E1 component
IPR017597 Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y
IPR029061 Thiamin diphosphate-binding fold

UniProt Annotations

Entry Information

Gene Name
pyruvate dehydrogenase E1 alpha subunit
Protein Entry
ODPA3_ARATH
UniProt ID
O24457
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO(2).
Cofactor Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence={ECO:0000250};
Function The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). {ECO:0000250}.
Sequence Caution Sequence=AAF26472.1; Type=Erroneous gene model prediction; Note=The predicted gene has been split into 2 genes: At1g01080 and At1g01090.; Evidence={ECO:0000305};
Subcellular Location Plastid, chloroplast {ECO:0000305}.
Subunit Tetramer of 2 alpha and 2 beta subunits. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011228 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15223294 RefSeq NP_171617 428 pyruvate dehydrogenase E1 alpha subunit

Identical Sequences to LMP011228 proteins

Reference Database Accession Length Protein Name
GI:15223294 GenBank ACH11936.1 428 Sequence 754 from patent US 7396979
GI:15223294 GenBank ACX16283.1 428 Sequence 43352 from patent US 7569389
GI:15223294 GenBank ACX17237.1 428 Sequence 44644 from patent US 7569389
GI:15223294 GenBank ADT60782.1 428 Sequence 2454 from patent US 7847156
GI:15223294 GenBank AEE27233.1 428 pyruvate dehydrogenase E1 component subunit alpha [Arabidopsis thaliana]
GI:15223294 GenBank AEL86164.1 428 Sequence 2517 from patent US 7989676

Related Sequences to LMP011228 proteins

Reference Database Accession Length Protein Name
GI:15223294 GenBank AAF26472.1 679 T25K16.8 [Arabidopsis thaliana]
GI:15223294 GenBank ACX16282.1 468 Sequence 43351 from patent US 7569389
GI:15223294 GenBank ACX17236.1 468 Sequence 44643 from patent US 7569389
GI:15223294 GenBank EFH65644.1 432 PDH-E1 alpha [Arabidopsis lyrata subsp. lyrata]
GI:15223294 GenBank AEL85659.1 428 Sequence 1654 from patent US 7989676
GI:15223294 RefSeq XP_002889385.1 432 PDH-E1 alpha [Arabidopsis lyrata subsp. lyrata]