Gene/Proteome Database (LMPD)

LMPD ID
LMP011252
Gene ID
836521
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
["3'(2'),5'-bisphosphate nucleotidase"]
Gene Symbol
SAL2
Synonyms
ATSAL2; MBM17.10; MBM17_10; SAL2
Alternate Names
3'(2'),5'-bisphosphate nucleotidase
Chromosome
5
EC Number
3.1.3.7

Proteins

3'(2'),5'-bisphosphate nucleotidase
Refseq ID NP_201205
Protein GI 15237589
UniProt ID O49623
mRNA ID NM_125796
Length 347
RefSeq Status REVIEWED
MSYEKELAAAKKAVTLAARLSQEVQKTLLQSQVWKKSDRSPVTAADYGSQAVVSLVLERELQPDKLSLVAEEETGDLRKNGSEAFLEDIAKLVKDTLASEESYTSSPLSTDDVLNAIDCGKSEGGCKGSHWVLDPIDGTRGFVRGEQYAVGLALLVEGKVVLGVMACPNLPLASAVCATDNSSQEDVGCLFFATTGSGTYVQSLKGNSLPQKVQVSSNENLDEAKFLESYHKPIPIHGTIAKKLGIKALPVRIDSQAKYAALSRGDAEIYLRFTLNGYRECIWDHAPGSIITTEAGGVVCDATGKSLDFSKGKYLAHKTGIIVTTKKLKPWILKAVRESIEEENLYF

Gene Information

Entrez Gene ID
836521
Gene Name
["3'(2'),5'-bisphosphate nucleotidase"]
Gene Symbol
SAL2
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0008441 IDA:TAIR F 3'(2'),5'-bisphosphate nucleotidase activity
GO:0016312 IDA:TAIR F inositol bisphosphate phosphatase activity
GO:0004441 IEA:UniProtKB-EC F inositol-1,4-bisphosphate 1-phosphatase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0016311 IDA:GOC P dephosphorylation
GO:0046854 IEA:InterPro P phosphatidylinositol phosphorylation
GO:0006790 IEA:InterPro P sulfur compound metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ath00562 Inositol phosphate metabolism
ath01100 Metabolic pathways
ath04070 Phosphatidylinositol signaling system
ath00920 Sulfur metabolism

Domain Information

InterPro Annotations

Accession Description
IPR006239 3(2),5 -bisphosphate nucleotidase HAL2
IPR020583 Inositol monophosphatase, metal-binding site
IPR000760 Inositol_monophosphatase

UniProt Annotations

Entry Information

Gene Name
["3'(2'),5'-bisphosphate nucleotidase"]
Protein Entry
DPNP2_ARATH
UniProt ID
O49623
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity 1D-myo-inositol 1,4-bisphosphate + H(2)O = 1D- myo-inositol 4-phosphate + phosphate.
Catalytic Activity Adenosine 3',5'-bisphosphate + H(2)O = adenosine 5'-phosphate + phosphate.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Enzyme Regulation Inhibited by Li(+) (IC(50)=10 millimolar), Na(+) (IC(50)=200 millimolar) and Ca(2+) (IC(50)=0.03 millimolar).
Function Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. May regulate the flux of sulfur in the sulfur-activation pathway by converting PAPS to APS (By similarity). Prevents both the toxicity of PAP on RNA processing enzymes as well as the product inhibition by PAP of sulfate conjugation. Is also able to hydrolyze inositol 1,4-bisphosphate. {ECO:0000250, ECO:0000269|PubMed:10205895}.
Miscellaneous Substrate preference is 3'-phosphoadenosine 5'- phosphate (PAP) > adenosine 3'-phosphate 5'-phosphosulfate (PAPS)>> inositol 1,4-bisphosphate. No activity observed against 3' or 5'-AMP, inositol monophosphate and fructose-1,6- bisphosphate.
Pathway Signal transduction; phosphatidylinositol signaling pathway.
Similarity Belongs to the inositol monophosphatase family. {ECO:0000305}.
Tissue Specificity Very low expression in roots, leaves, stems, flowers and siliques.

Identical and Related Proteins

Unique RefSeq proteins for LMP011252 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15237589 RefSeq NP_201205 347 3'(2'),5'-bisphosphate nucleotidase

Identical Sequences to LMP011252 proteins

Reference Database Accession Length Protein Name
GI:15237589 DBBJ BAA96903.1 347 3'(2'),5'-bisphosphate nucleotidase [Arabidopsis thaliana]
GI:15237589 EMBL CAB05889.1 347 3'(2'),5'-bisphosphate nucleotidase [Arabidopsis thaliana]
GI:15237589 GenBank AAL49879.1 347 putative 3(2),5-bisphosphate nucleotidase [Arabidopsis thaliana]
GI:15237589 GenBank AAM20225.1 347 putative 3(2),5-bisphosphate nucleotidase [Arabidopsis thaliana]
GI:15237589 gnl TAIR 347 3'(2'),5'-bisphosphate nucleotidase [Arabidopsis thaliana]
GI:15237589 SwissProt O49623.1 347 RecName: Full=SAL2 phosphatase; AltName: Full=3'(2'),5'-bisphosphate nucleotidase 2; AltName: Full=3'(2'),5'-bisphosphonucleoside 3'(2')-phosphohydrolase 2; AltName: Full=DPNPase 2; AltName: Full=Inositol polyphosphate 1-phosphatase 2; Short=IPPase 2; AltName: Full=Inositol-1,4-bisphosphate 1-phosphatase 2 [Arabidopsis thaliana]

Related Sequences to LMP011252 proteins

Reference Database Accession Length Protein Name
GI:15237589 GenBank EFH41141.1 347 hypothetical protein ARALYDRAFT_496594 [Arabidopsis lyrata subsp. lyrata]
GI:15237589 GenBank KFK28090.1 347 hypothetical protein AALP_AA8G471000 [Arabis alpina]
GI:15237589 RefSeq XP_002864882.1 347 hypothetical protein ARALYDRAFT_496594 [Arabidopsis lyrata subsp. lyrata]
GI:15237589 RefSeq XP_006281488.1 347 hypothetical protein CARUB_v10027581mg [Capsella rubella]
GI:15237589 RefSeq XP_010461293.1 347 PREDICTED: SAL2 phosphatase-like [Camelina sativa]
GI:15237589 RefSeq XP_010444323.1 347 PREDICTED: SAL2 phosphatase [Camelina sativa]