Gene/Proteome Database (LMPD)

LMPD ID
LMP011267
Gene ID
829184
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
serine carboxypeptidase 24
Gene Symbol
BRS1
Synonyms
BRI1 SUPPRESSOR 1; BRS1; F17I23.50; F17I23_50; SCPL24; SERINE CARBOXYPEPTIDASE 24 PRECURSOR
Alternate Names
serine carboxypeptidase 24
Chromosome
4
EC Number
3.4.16.6
Summary
Encodes a secreted glycosylated serine carboxypeptidase with broad substrate preference that is involved in brassinosteroid signalling via BRI1. It is proteolytically processed in vivo by a separate as yet unidentified protease.
Orthologs
View orthologs and multiple alignments for BRS1

Proteins

serine carboxypeptidase 24
Refseq ID NP_194790
Protein GI 15234795
UniProt ID Q9M099
mRNA ID NM_119207
Length 465
RefSeq Status REVIEWED
MARTHFIFLLLVALLSTTFPSSSSSREQEKDRIKALPGQPKVAFSQYSGYVNVNQSHGRALFYWLTESSSPSPHTKPLLLWLNGGPGCSSIAYGASEEIGPFRINKTGSNLYLNKFAWNKDANLLFLESPAGVGYSYTNTSSDLKDSGDERTAQDNLIFLIKWLSRFPQYKYRDFYIAGESYAGHYVPQLAKKINDYNKAFSKPIINLKGFLVGNAVTDNQYDSIGTVTYWWTHAIISDKSYKSILKYCNFTVERVSDDCDNAVNYAMNHEFGDIDQYSIYTPTCVAAQQKKNTTGFFVRMKNTLLRRRLVSGYDPCTESYAEKYFNRPDVQRAMHANVTGIRYKWTACSDVLIKTWKDSDKTMLPIYKELAASGLRIWIFSGDTDSVVPVTATRFSLSHLNLPVKTRWYPWYTDNQVGGWTEVYKGLTFATVRGAGHEVPLFEPKRALILFRSFLAGKELPRSY

Gene Information

Entrez Gene ID
829184
Gene Name
serine carboxypeptidase 24
Gene Symbol
BRS1
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005615 IDA:TAIR C extracellular space
GO:0004185 IDA:TAIR F serine-type carboxypeptidase activity
GO:0009742 IGI:TAIR P brassinosteroid mediated signaling pathway
GO:0006508 IDA:TAIR P proteolysis

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR001563 Peptidase S10, serine carboxypeptidase
IPR018202 Peptidase S10, serine carboxypeptidase, active site

UniProt Annotations

Entry Information

Gene Name
serine carboxypeptidase 24
Protein Entry
SCP24_ARATH
UniProt ID
Q9M099
Species
Arabidopsis

Comments

Comment Type Description
Biophysicochemical Properties pH dependence: Optimum pH is 5.5. {ECO:0000269|PubMed:16123046}; Temperature dependence: Optimum temperature is 50 degrees Celsius. {ECO:0000269|PubMed:16123046};
Catalytic Activity Preferential release of a C-terminal arginine or lysine residue.
Enzyme Regulation Completely inhibited by phenylmethylsulfonyl fluoride (PMSF) and partially by leupeptin. {ECO:0000269|PubMed:16123046}.
Function Active serine carboxypeptidase with broad substrate preference, including basic and hydrophilic groups. Processes a protein involved in an early event in the brassinosteroid signaling pathway. {ECO:0000269|PubMed:11320207, ECO:0000269|PubMed:16123046}.
Miscellaneous Was isolated as a suppressor of bri1 mutant phenotype. The serine carboxypeptidase activity is necessary for suppression of bri1 mutant phenotype.
Ptm N-glycosylated. {ECO:0000269|PubMed:16123046}.
Similarity Belongs to the peptidase S10 family. {ECO:0000305}.
Subcellular Location Secreted, extracellular space {ECO:0000269|PubMed:16123046}.
Subunit Heterodimer. {ECO:0000305}.
Tissue Specificity Expressed in shoots, leaves, cauline leaves, siliques and flowers. Expressed a low levels in roots and stems. {ECO:0000269|PubMed:15908604, ECO:0000269|PubMed:16123046}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011267 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15234795 RefSeq NP_194790 465 serine carboxypeptidase 24

Identical Sequences to LMP011267 proteins

Reference Database Accession Length Protein Name
GI:15234795 EMBL CAB79779.1 465 SERINE CARBOXYPEPTIDASE II-like protein [Arabidopsis thaliana]
GI:15234795 GenBank AAN86167.1 465 putative serine carboxypeptidase II [Arabidopsis thaliana]
GI:15234795 GenBank AEE85786.1 465 serine carboxypeptidase 24 [Arabidopsis thaliana]
GI:15234795 SwissProt Q9M099.1 465 RecName: Full=Serine carboxypeptidase 24; AltName: Full=Bri1 suppressor 1; AltName: Full=Carboxypeptidase D; AltName: Full=Serine carboxypeptidase II; Contains: RecName: Full=Serine carboxypeptidase 24 chain A; AltName: Full=Serine carboxypeptidase II chain A; Contains: RecName: Full=Serine carboxypeptidase 24 chain B; AltName: Full=Serine carboxypeptidase II chain B; Flags: Precursor [Arabidopsis thaliana]

Related Sequences to LMP011267 proteins

Reference Database Accession Length Protein Name
GI:15234795 GenBank AAK44013.1 465 putative serine carboxypeptidase II [Arabidopsis thaliana]
GI:15234795 GenBank EFH45628.1 466 hypothetical protein ARALYDRAFT_491690 [Arabidopsis lyrata subsp. lyrata]
GI:15234795 GenBank EOA18692.1 467 hypothetical protein CARUB_v10007268mg [Capsella rubella]
GI:15234795 RefSeq XP_002869369.1 466 hypothetical protein ARALYDRAFT_491690 [Arabidopsis lyrata subsp. lyrata]
GI:15234795 RefSeq XP_006285794.1 467 hypothetical protein CARUB_v10007268mg [Capsella rubella]
GI:15234795 RefSeq XP_010432963.1 469 PREDICTED: serine carboxypeptidase 24 isoform X1 [Camelina sativa]