Gene/Proteome Database (LMPD)

LMPD ID
LMP011286
Gene ID
822566
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
SNF1-related protein kinase catalytic subunit alpha KIN11
Gene Symbol
KIN11
Synonyms
AKIN11; ATKIN11; KIN11; SNF1 kinase homolog 11; SNF1-RELATED PROTEIN KINASE; SNF1-RELATED PROTEIN KINASE 1.2; SNRK1.2
Alternate Names
SNF1-related protein kinase catalytic subunit alpha KIN11
Chromosome
3
EC Number
2.7.11.1
Summary
encodes a SNF1-related protein kinase that physically interacts with SCF subunit SKP1/ASK1 and 20S proteosome subunit PAD1. It has also been shown to interact with the WD protein PDL1.
Orthologs
View orthologs and multiple alignments for KIN11

Proteins

SNF1-related protein kinase catalytic subunit alpha KIN11
Refseq ID NP_566843
Protein GI 18406082
UniProt ID P92958
mRNA ID NM_113839
Length 512
RefSeq Status REVIEWED
MDHSSNRFGNNGVESILPNYKLGKTLGIGSFGKVKIAEHVVTGHKVAIKILNRRKIKNMEMEEKVRREIKILRLFMHPHIIRQYEVIETTSDIYVVMEYVKSGELFDYIVEKGRLQEDEARNFFQQIISGVEYCHRNMVVHRDLKPENLLLDSRCNIKIADFGLSNVMRDGHFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGTLPFDDENIPNLFKKIKGGIYTLPSHLSSEARDLIPRMLIVDPVKRITIPEIRQHRWFQTHLPRYLAVSPPDTVEQAKKINEEIVQEVVNMGFDRNQVLESLRNRTQNDATVTYYLLLDNRFRVPSGYLESEFQETTDSGSNPMRTPEAGASPVGHWIPAHVDHYGLGARSQVPVDRKWALGLQSHAHPREIMNEVLKALQELNVCWKKIGHYNMKCRWVPGLADGQNTMVNNQLHFRDESSIIEDDCAMTSPTVIKFELQLYKAREEKYLLDIQRVNGPQFLFLDLCAAFLTELRVI
SNF1-related protein kinase catalytic subunit alpha KIN11
Refseq ID NP_974374
Protein GI 42572557
UniProt ID P92958
mRNA ID NM_202645
Length 512
RefSeq Status REVIEWED
Protein sequence is identical to GI:18406082 (mRNA isoform)
SNF1-related protein kinase catalytic subunit alpha KIN11
Refseq ID NP_974375
Protein GI 42572559
UniProt ID P92958
mRNA ID NM_202646
Length 359
RefSeq Status REVIEWED
MDHSSNRFGNNGVESILPNYKLGKTLGIGSFGKVKIAEHVVTGHKVAIKILNRRKIKNMEMEEKVRREIKILRLFMHPHIIRQYEVIETTSDIYVVMEYVKSGELFDYIVEKGRLQEDEARNFFQQIISGVEYCHRNMVVHRDLKPENLLLDSRCNIKIADFGLSNVMRDGHFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGTLPFDDENIPNLFKKIKGGIYTLPSHLSSEARDLIPRMLIVDPVKRITIPEIRQHRWFQTHLPRYLAVSPPDTVEQAKKINEEIVQEVVNMGFDRNQVLESLRNRTQNDATVTYYLLLDNRFRVPSGYLESEFQETTWFQSYAHT

Gene Information

Entrez Gene ID
822566
Gene Name
SNF1-related protein kinase catalytic subunit alpha KIN11
Gene Symbol
KIN11
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004672 IDA:TAIR F protein kinase activity
GO:0004674 IEA:UniProtKB-KW F protein serine/threonine kinase activity
GO:0005975 IEA:UniProtKB-KW P carbohydrate metabolic process
GO:0006633 IEA:UniProtKB-KW P fatty acid biosynthetic process
GO:0042128 IEA:UniProtKB-KW P nitrate assimilation
GO:0046777 IDA:TAIR P protein autophosphorylation
GO:0006468 IDA:TAIR P protein phosphorylation
GO:0050688 IEA:UniProtKB-KW P regulation of defense response to virus
GO:0016032 IEA:UniProtKB-KW P viral process

KEGG Pathway Links

KEGG Pathway ID Description
ath04140 Regulation of autophagy

REACTOME Pathway Links

REACTOME Pathway ID Description
6253966 AMPK inhibits chREBP transcriptional activation activity
6254145 Regulation of AMPK activity via LKB1
6254302 Translocation of GLUT4 to the plasma membrane

Domain Information

InterPro Annotations

Accession Description
IPR028375 KA1 domain/Ssp2 C-terminal domain
IPR001772 Kinase associated domain 1 (KA1)
IPR017441 Protein kinase, ATP binding site
IPR000719 Protein kinase domain
IPR011009 Protein kinase-like domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR008271 Serine/threonine-protein kinase, active site
IPR009060 UBA-like
IPR000449 Ubiquitin-associated domain/translation elongation factor EF-Ts, N-terminal
IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote

UniProt Annotations

Entry Information

Gene Name
SNF1-related protein kinase catalytic subunit alpha KIN11
Protein Entry
KIN11_ARATH
UniProt ID
P92958
Species
Arabidopsis

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P92958-1; Sequence=Displayed; Name=2; IsoId=P92958-2; Sequence=VSP_034567, VSP_034568; Note=Derived from EST data. No experimental confirmation available.;
Catalytic Activity ATP + a protein = ADP + a phosphoprotein.
Enzyme Regulation Inactivated by the begomovirus AL2 protein or the curtovirus L2 protein. Activated by phosphorylation at Thr- 176. {ECO:0000269|PubMed:12671096, ECO:0000269|PubMed:19339507}.
Function Catalytic subunit of the probable trimeric SNF1-related protein kinase (SnRK) complex, which may play a role in a signal transduction cascade regulating gene expression and carbohydrate metabolism in higher plants. The SnRK complex may also be involved in the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase and in assimilation of nitrogen by phosphorylating nitrate reductase. In vitro, KIN11 exhibits kinase activity on sucrose phosphate synthase and the kinase activity is inhibited by PRL1. May be a subunit of a SCF ubiquitin ligase complex and thus be involved in proteasomal ubiquitination. Involved in innate antiviral defenses. {ECO:0000269|PubMed:10220464, ECO:0000269|PubMed:11387208}.
Induction Induced by sucrose. {ECO:0000269|PubMed:10220464}.
Interaction Q9FEB5:DSP4; NbExp=2; IntAct=EBI-307202, EBI-307215; Q9SCY5:KINB2; NbExp=4; IntAct=EBI-307202, EBI-2042436; Q42384:PRL1; NbExp=2; IntAct=EBI-307202, EBI-1382964; Q9LVG2:TOE2; NbExp=2; IntAct=EBI-307202, EBI-4424568;
Ptm Autophosphorylated. Phosphorylated at Thr-176 by GRIK1/SNAK2 and GRIK2/SNAK1. {ECO:0000269|PubMed:19339507}.
Similarity Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. {ECO:0000305}.
Similarity Contains 1 KA1 (kinase-associated) domain. {ECO:0000255|PROSITE-ProRule:PRU00565}.
Similarity Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
Similarity Contains 1 UBA domain. {ECO:0000255|PROSITE- ProRule:PRU00212}.
Subunit Subunit of a probable heterotrimeric complex consisting of an alpha catalytic (KIN10 or KIN11) subunit, and a beta (KINB) and a gamma (KING or SNF4) non-catalytic regulatory subunits. Interacts with KINB2, KINB3, SNF4 and probably with KINB1 and KING1. Interacts with SKP1/ASK1, PAD1 and the N-terminus of PRL1. Potential subunit of a SCF ubiquitin ligase complex consisting of a SNF1-related protein kinase, SKP1 and CUL1. The association of the SCF complex with the proteasome may be mediated by PAD1 and seems to be inhibited by the interaction with PRL1. Interacts with DSP4. Interacts with the begomovirus AL2 protein and the curtovirus L2 protein. {ECO:0000269|PubMed:10220464, ECO:0000269|PubMed:10417704, ECO:0000269|PubMed:10929106, ECO:0000269|PubMed:11387208, ECO:0000269|PubMed:11522840, ECO:0000269|PubMed:12148529, ECO:0000269|PubMed:12671096, ECO:0000269|PubMed:15803412}.
Tissue Specificity Expressed in roots, shoots, flower buds, flowers, siliques and leaves. {ECO:0000269|PubMed:10417704}.
Web Resource Name=PlantP kinase Classification PPC; URL="http://plantsp.genomics.purdue.edu/family/class.html";

Identical and Related Proteins

Unique RefSeq proteins for LMP011286 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18406082 RefSeq NP_566843 512 SNF1-related protein kinase catalytic subunit alpha KIN11
42572559 RefSeq NP_974375 359 SNF1-related protein kinase catalytic subunit alpha KIN11

Identical Sequences to LMP011286 proteins

Reference Database Accession Length Protein Name
GI:18406082 GenBank AAN31081.1 512 At3g29160/MXE2_16 [Arabidopsis thaliana]
GI:18406082 GenBank ABH11526.1 512 SNR1 [Arabidopsis thaliana]
GI:18406082 GenBank AEE77542.1 512 SNF1-related protein kinase catalytic subunit alpha KIN11 [Arabidopsis thaliana]
GI:18406082 GenBank AEE77543.1 512 SNF1-related protein kinase catalytic subunit alpha KIN11 [Arabidopsis thaliana]
GI:42572559 GenBank AEE77544.1 359 SNF1-related protein kinase catalytic subunit alpha KIN11 [Arabidopsis thaliana]
GI:18406082 RefSeq NP_974374.1 512 SNF1-related protein kinase catalytic subunit alpha KIN11 [Arabidopsis thaliana]
GI:18406082 SwissProt P92958.1 512 RecName: Full=SNF1-related protein kinase catalytic subunit alpha KIN11; Short=AKIN11; AltName: Full=AKIN alpha-1; Short=AKINalpha1 [Arabidopsis thaliana]

Related Sequences to LMP011286 proteins

Reference Database Accession Length Protein Name
GI:42572559 DBBJ BAB01993.1 512 AKin11 protein kinase [Arabidopsis thaliana]
GI:18406082 DBBJ BAH19920.1 512 AT3G29160 [Arabidopsis thaliana]
GI:42572559 EMBL CAA67671.1 512 AKin11 [Arabidopsis thaliana]
GI:18406082 EMBL CAA64382.1 512 ser/thr protein kinase [Arabidopsis thaliana]
GI:42572559 GenBank AAL49934.1 512 AT3g29160/MXE2_16 [Arabidopsis thaliana]
GI:18406082 GenBank AAW01769.1 512 Sequence 2 from patent US 6777587
GI:18406082 GenBank EOA23756.1 543 hypothetical protein CARUB_v10016968mg, partial [Capsella rubella]
GI:18406082 GenBank EOA23757.1 512 hypothetical protein CARUB_v10016968mg [Capsella rubella]
GI:42572559 RefSeq NP_566843.1 512 SNF1-related protein kinase catalytic subunit alpha KIN11 [Arabidopsis thaliana]
GI:42572559 RefSeq NP_974374.1 512 SNF1-related protein kinase catalytic subunit alpha KIN11 [Arabidopsis thaliana]
GI:18406082 RefSeq XP_006290858.1 543 hypothetical protein CARUB_v10016968mg, partial [Capsella rubella]
GI:42572559 SwissProt P92958.1 512 RecName: Full=SNF1-related protein kinase catalytic subunit alpha KIN11; Short=AKIN11; AltName: Full=AKIN alpha-1; Short=AKINalpha1 [Arabidopsis thaliana]