Gene/Proteome Database (LMPD)

LMPD ID
LMP011305
Gene ID
839691
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
Sphingosine-1-phosphate lyase
Gene Symbol
DPL1
Synonyms
ATDPL1; dihydrosphingosine phosphate lyase; DPL1; F13K9.8; F13K9_8
Alternate Names
Sphingosine-1-phosphate lyase
Chromosome
1
EC Number
4.1.2.27

Proteins

Sphingosine-1-phosphate lyase
Refseq ID NP_174119
Protein GI 15217780
UniProt ID Q9C509
mRNA ID NM_102563
Length 544
RefSeq Status REVIEWED
MDSFSYSSMKSMLIQARGSLNSRLSEFEPLVLLLVPLVSLFLAQIIGSVFGVVHEKGLKACLIGFIMGLLKMIPGVQNYIDAEKQKVVDQLQSGSSSKKKNKTEVLPVKGLGVEVLEKMENEKRNDAIWQGKCSGTVYIGGAESEGHFSLINQACSMFAHTNPLHIDVFQSVVRFESEVVAMTAALLGSKETASGGQICGNMTSGGTESIVLAVKSSRDYMKYKKGITRPEMIIPESGHSAYDKAAQYFKIKLWRVPVDKDFRADVKATRRHINRNTIMIVGSAPGFPHGIIDPIEELGQLALSYGICFHVDLCLGGFVLPFARKLGYQIPPFDFSVQGVTSISVDVHKYGLAPKGTSTVLYRNHEIRKHQFVAVTEWSGGLYVSPTIAGSRPGSLVAGAWAAMMSLGEEGYLQNTSKIMEASKRLEEGVREIHELFVIGKPDMTIVAFGSKALDIFEVNDIMSSKGWHLNALQRPNSIHICITLQHVPVVDDFLRDLREAVETVKANPGPITGGLAPIYGAAGKMPDRGMVNELLVSFMDSQY

Gene Information

Entrez Gene ID
839691
Gene Name
Sphingosine-1-phosphate lyase
Gene Symbol
DPL1
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:TAIR C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016020 IDA:TAIR C membrane
GO:0016831 IEA:InterPro F carboxy-lyase activity
GO:0030170 IEA:InterPro F pyridoxal phosphate binding
GO:0008117 IEA:UniProtKB-EC F sphinganine-1-phosphate aldolase activity
GO:0019752 IEA:InterPro P carboxylic acid metabolic process
GO:0006950 IEA:UniProtKB-KW P response to stress
GO:0030149 IMP:TAIR P sphingolipid catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ath01100 Metabolic pathways
ath00600 Sphingolipid metabolism
ath_M00100 Sphingosine degradation

REACTOME Pathway Links

REACTOME Pathway ID Description
6254191 Sphingolipid de novo biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR002129 Pyridoxal phosphate-dependent decarboxylase
IPR015424 Pyridoxal phosphate-dependent transferase
IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1

UniProt Annotations

Entry Information

Gene Name
Sphingosine-1-phosphate lyase
Protein Entry
SGPL_ARATH
UniProt ID
Q9C509
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity Sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde. {ECO:0000269|PubMed:17635905, ECO:0000269|PubMed:18849574}.
Cofactor Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000250};
Disruption Phenotype No visible phenotype under normal growth conditions. {ECO:0000269|PubMed:18849574}.
Function Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. May play a minor role in maintenance of sphingolipid metabolism during normal plant development and growth, but be required for maintaining sphingoid long chain bases (LCB) and their phosphorylated derivatives (LCB-P) levels when sphingolipid metabolism is perturbed. May play a role in dehydration stress. {ECO:0000269|PubMed:17635905, ECO:0000269|PubMed:18849574}.
Pathway Lipid metabolism; sphingolipid metabolism.
Sequence Caution Sequence=AAM62669.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Similarity Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000305|PubMed:17635905, ECO:0000305|PubMed:18849574}; Single-pass type III membrane protein {ECO:0000305|PubMed:17635905, ECO:0000305|PubMed:18849574}.
Tissue Specificity Expressed in the peripheral parts of leaves and the bases of trichomes. {ECO:0000269|PubMed:18849574}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011305 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15217780 RefSeq NP_174119 544 Sphingosine-1-phosphate lyase

Identical Sequences to LMP011305 proteins

Reference Database Accession Length Protein Name
GI:15217780 DBBJ BAD13416.1 544 sphingosine-1-phosphate lyase [Arabidopsis thaliana]
GI:15217780 EMBL CAY04626.1 544 unnamed protein product [Arabidopsis thaliana]
GI:15217780 GenBank AAK25876.1 544 putative sphingosine-1-phosphate lyase [Arabidopsis thaliana]
GI:15217780 GenBank AAM44962.1 544 putative sphingosine-1-phosphate lyase [Arabidopsis thaliana]
GI:15217780 GenBank AEE30898.1 544 Sphingosine-1-phosphate lyase [Arabidopsis thaliana]
GI:15217780 SwissProt Q9C509.1 544 RecName: Full=Sphingosine-1-phosphate lyase; Short=AtSPL1; Short=S1PL; Short=SP-lyase; Short=SPL; AltName: Full=Dihydrosphingosine phosphate lyase 1; Short=AtDPL1; AltName: Full=Sphingosine-1-phosphate aldolase [Arabidopsis thaliana]

Related Sequences to LMP011305 proteins

Reference Database Accession Length Protein Name
GI:15217780 GenBank EFH67013.1 544 pyridoxal-dependent decarboxylase family protein [Arabidopsis lyrata subsp. lyrata]
GI:15217780 GenBank EOA37762.1 544 hypothetical protein CARUB_v10012601mg [Capsella rubella]
GI:15217780 RefSeq XP_002890754.1 544 pyridoxal-dependent decarboxylase family protein [Arabidopsis lyrata subsp. lyrata]
GI:15217780 RefSeq XP_006304864.1 544 hypothetical protein CARUB_v10012601mg [Capsella rubella]
GI:15217780 RefSeq XP_010499294.1 544 PREDICTED: sphingosine-1-phosphate lyase-like isoform X2 [Camelina sativa]
GI:15217780 RefSeq XP_010460568.1 544 PREDICTED: sphingosine-1-phosphate lyase [Camelina sativa]