Gene/Proteome Database (LMPD)

LMPD ID
LMP011308
Gene ID
829932
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
squalene epoxidase 3
Gene Symbol
SQE3
Synonyms
squalene epoxidase 3; T28I19.40; T28I19_40
Alternate Names
squalene epoxidase 3
Chromosome
4
EC Number
1.14.13.132

Proteins

squalene epoxidase 3
Refseq ID NP_568033
Protein GI 18420113
UniProt ID Q8VYH2
mRNA ID NM_119938
Length 525
RefSeq Status REVIEWED
MAPTIFVDHCILTTTFVASLFAFLLLYVLRRRSKTIHGSVNVRNGTLTVKSGTDVDIIIVGAGVAGAALAHTLGKEGRRVHVIERDLTEPDRIVGELLQPGGYLKLIELGLEDCVKDIDAQRVLGYALFKDGKHTKLSYPLDQFDSDVAGRSFHNGRFVQRMREKASLLPNVRMEQGTVTSLVEENGIIKGVQYKTKDGQELKSFAPLTIVCDGCFSNLRRSLCKPKVEVPSNFVGLVLENCELPFPNHGHVVLGDPSPILFYPISSSEVRCLVDVPGSKLPSVASGEMAHHLKTMVAPQVPPQIRDAFISAVEKGNIRTMPNRSMPADPIHTPGALLLGDAFNMRHPLTGGGMTVALSDIVILRDLLNPLVDLTNKESLSKYIESFYTLRKPVASTINTLAGALYKVFLASPDDARSEMRRACFDYLSLGGVCSSGPVALLSGLNPRPMSLVLHFFAVAIFGVGRLLVPLPSVKRLWLGARLISSASGIIFPIIKAEGVRQMFFPRTIPAIYRAPPTPSSSSPQ

Gene Information

Entrez Gene ID
829932
Gene Name
squalene epoxidase 3
Gene Symbol
SQE3
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0050660 IEA:InterPro F flavin adenine dinucleotide binding
GO:0004506 IGI:TAIR F squalene monooxygenase activity
GO:0009753 IEP:TAIR P response to jasmonic acid
GO:0009611 IEP:TAIR P response to wounding
GO:0016126 TAS:TAIR P sterol biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ath00909 Sesquiterpenoid and triterpenoid biosynthesis
ath00100 Steroid biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
6254329 Activation of gene expression by SREBF (SREBP)
6254036 Cholesterol biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR003042 Aromatic-ring hydroxylase-like
IPR013698 Squalene_epoxidase

UniProt Annotations

Entry Information

Gene Name
squalene epoxidase 3
Protein Entry
ERG16_ARATH
UniProt ID
Q8VYH2
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity Squalene + NADPH + O(2) = (3S)-2,3-epoxy-2,3- dihydrosqualene + NADP(+) + H(2)O. {ECO:0000269|PubMed:17426032}.
Cofactor Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
Function Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway. Can produce not only oxidosqualene, but also 2,3:22,23-dioxidosqualene. {ECO:0000269|PubMed:17426032}.
Pathway Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 2/3.
Sequence Caution Sequence=CAB38924.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAB80441.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity Belongs to the squalene monooxygenase family. {ECO:0000305}.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity Expressed in seedlings, leaves, stems, inflorescences and siliques. {ECO:0000269|PubMed:17426032}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011308 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18420113 RefSeq NP_568033 525 squalene epoxidase 3

Identical Sequences to LMP011308 proteins

Reference Database Accession Length Protein Name
GI:18420113 DBBJ BAE98940.1 525 hypothetical protein [Arabidopsis thaliana]
GI:18420113 GenBank AAL57712.1 525 AT4g37760/T28I19_40 [Arabidopsis thaliana]
GI:18420113 GenBank AAN46811.1 525 At4g37760/T28I19_40 [Arabidopsis thaliana]
GI:18420113 GenBank AEE86835.1 525 squalene epoxidase 3 [Arabidopsis thaliana]
GI:18420113 SwissProt Q8VYH2.1 525 RecName: Full=Squalene epoxidase 3; Short=AtSQE3 [Arabidopsis thaliana]

Related Sequences to LMP011308 proteins

Reference Database Accession Length Protein Name
GI:18420113 EMBL CAB38924.1 530 squalene epoxidase-like protein [Arabidopsis thaliana]
GI:18420113 EMBL CAB80441.1 530 squalene epoxidase-like protein [Arabidopsis thaliana]
GI:18420113 GenBank AAM61384.1 525 squalene epoxidase-like protein [Arabidopsis thaliana]
GI:18420113 GenBank EFH45225.1 521 hypothetical protein ARALYDRAFT_490840 [Arabidopsis lyrata subsp. lyrata]
GI:18420113 GenBank AEL86112.1 525 Sequence 2429 from patent US 7989676
GI:18420113 RefSeq XP_002868966.1 521 hypothetical protein ARALYDRAFT_490840 [Arabidopsis lyrata subsp. lyrata]