Gene/Proteome Database (LMPD)

LMPD ID
LMP011312
Gene ID
829616
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
Squalene synthase 1
Gene Symbol
SQS1
Synonyms
ERG9; SQS1; SQUALENE SYNTHASE; squalene synthase 1; T4L20.220; T4L20_220
Alternate Names
Squalene synthase 1
Chromosome
4
EC Number
2.5.1.21
Summary
Encodes squalene synthase, which converts two molecules of farnesyl diphosphate (FPP) into squalene via an intermediate: presqualene diphosphate (PSPP). It is generally thought to be one of the key enzymes of sterol biosynthesis, since it catalyzes the first pathway-specific reaction of the sterol branch of the isoprenoid pathway.
Orthologs
View orthologs and multiple alignments for SQS1

Proteins

Squalene synthase 1
Refseq ID NP_195190
Protein GI 15236168
UniProt ID P53799
mRNA ID NM_119630
Length 410
RefSeq Status REVIEWED
MGSLGTMLRYPDDIYPLLKMKRAIEKAEKQIPPEPHWGFCYSMLHKVSRSFSLVIQQLNTELRNAVCVFYLVLRALDTVEDDTSIPTDEKVPILIAFHRHIYDTDWHYSCGTKEYKILMDQFHHVSAAFLELEKGYQEAIEEITRRMGAGMAKFICQEVETVDDYDEYCHYVAGLVGLGLSKLFLAAGSEVLTPDWEAISNSMGLFLQKTNIIRDYLEDINEIPKSRMFWPREIWGKYADKLEDLKYEENTNKSVQCLNEMVTNALMHIEDCLKYMVSLRDPSIFRFCAIPQIMAIGTLALCYNNEQVFRGVVKLRRGLTAKVIDRTKTMADVYGAFYDFSCMLKTKVDKNDPNASKTLNRLEAVQKLCRDAGVLQNRKSYVNDKGQPNSVFIIMVVILLAIVFAYLRAN

Gene Information

Entrez Gene ID
829616
Gene Name
Squalene synthase 1
Gene Symbol
SQS1
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:TAIR C endoplasmic reticulum
GO:0005789 TAS:TAIR C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IDA:TAIR C plasma membrane
GO:0004310 IDA:TAIR F farnesyl-diphosphate farnesyltransferase activity
GO:0016491 IEA:UniProtKB-KW F oxidoreductase activity
GO:0051996 IEA:UniProtKB-EC F squalene synthase activity
GO:0008299 IEA:UniProtKB-KW P isoprenoid biosynthetic process
GO:0016126 TAS:TAIR P sterol biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ath01110 Biosynthesis of secondary metabolites
ath00909 Sesquiterpenoid and triterpenoid biosynthesis
ath00100 Steroid biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
6254036 Cholesterol biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR006449 Farnesyl-diphosphate farnesyltransferase
IPR008949 Isoprenoid synthase domain
IPR002060 Squalene/phytoene synthase
IPR019845 Squalene/phytoene synthase, conserved site

UniProt Annotations

Entry Information

Gene Name
Squalene synthase 1
Protein Entry
FDFT_ARATH
UniProt ID
P53799
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity 2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)(+).
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Pathway Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.
Similarity Belongs to the phytoene/squalene synthase family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue Specificity Expressed in all tissues analyzed (inflorescences, leaves, stems and roots). Highly expressed in roots. {ECO:0000269|PubMed:9363754}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011312 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15236168 RefSeq NP_195190 410 Squalene synthase 1

Identical Sequences to LMP011312 proteins

Reference Database Accession Length Protein Name
GI:15236168 EMBL CBK51614.1 410 unnamed protein product [Arabidopsis thaliana]
GI:15236168 GenBank AAO30082.1 410 putative squalene synthase [Arabidopsis thaliana]
GI:15236168 GenBank AEE86403.1 410 Squalene synthase [Arabidopsis thaliana]
GI:15236168 GenBank AFO09003.1 410 Sequence 178 from patent US 8222482
GI:15236168 GenBank AFX49050.1 410 Sequence 50883 from patent US 8299318
GI:15236168 GenBank AGF14630.1 410 Sequence 14049 from patent US 8362325

Related Sequences to LMP011312 proteins

Reference Database Accession Length Protein Name
GI:15236168 GenBank EFH45392.1 412 hypothetical protein ARALYDRAFT_912921 [Arabidopsis lyrata subsp. lyrata]
GI:15236168 GenBank AFX28118.1 410 Sequence 9178 from patent US 8299318
GI:15236168 GenBank AGF14016.1 410 Sequence 13435 from patent US 8362325
GI:15236168 GenBank EOA16726.1 414 hypothetical protein CARUB_v10004929mg [Capsella rubella]
GI:15236168 RefSeq XP_002869133.1 412 hypothetical protein ARALYDRAFT_912921 [Arabidopsis lyrata subsp. lyrata]
GI:15236168 RefSeq XP_006283828.1 414 hypothetical protein CARUB_v10004929mg [Capsella rubella]