Gene/Proteome Database (LMPD)

LMPD ID
LMP011417
Gene ID
827526
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
Type I inositol-1,4,5-trisphosphate 5-phosphatase 2
Gene Symbol
5PTASE2
Synonyms
4; 5)P3 5-PHOSPHATASE II; 5PTASE2; AT5PTASE2; INOSITOL POLYPHOSPHATE 5-PHOSPHATASE II; INOSITOL(1; IP5PII; myo-inositol polyphosphate 5-phosphatase 2; T6K21.190; T6K21_190
Alternate Names
Type I inositol-1,4,5-trisphosphate 5-phosphatase 2
Chromosome
4
EC Number
3.1.3.56
Summary
Encodes an inositol polyphosphate 5-phosphatase that appears to have Type I activity. It can dephosphorylate IP3(inositol(1,4,5)P3) and IP4 (inositol(1,3,4,5)P4), but it does not appear to be active against phosphatidylinositol 4,5 bisphosphate. Overexpression of this gene renders plants insensitive to ABA in germination and growth assays.
Orthologs
View orthologs and multiple alignments for 5PTASE2

Proteins

Type I inositol-1,4,5-trisphosphate 5-phosphatase 2
Refseq ID NP_849402
Protein GI 30684260
UniProt ID Q9FUR2
mRNA ID NM_179071
Length 613
RefSeq Status REVIEWED
MKTRRGKRPERFWPSIVMNKWLNRKPKVYDFSEDEIDTEPESEDDVCSVKDVPNVHCVTDEDSHNGRRGSEADHGNNISDGGVSVRGGYQRKHRRGKSETLRAQYINTKDIKVTVATWNVAGKRPSDDLEIEDWLSTDNPSDIYIIGFQEVVPLNAGNVFGAEDRGPIPKWESIIRRTLNKSNKESVYDQSPSCNNNALHRSHSAPSSPILAQEANSIISHVMVENLVADHSLDLATNEFIDAATALPSLEPQRNPNMDWPELALDSNPQIVGSEGKLRRVFSSNATLGFKLPENPSGASRFASEARQLKRSRSFETLNLSWNDIKEEDGDKIRNSYGLPEDLVEECRKVKDSQKYVRIVSKQMVGIYVSVWIRRRLRRHVNNLKVSPVGVGLMGYMGNKGSVSISMTLYQSRMCFVCSHLTSGHKDGAEQRRNADVYEIIRRTRFASVLDTDQPRTIPCHDQVFWFGDLNYRLNMSDGEVRKLVSQKRWDELKNSDQLIRELRRGHVFDGWREGPIKFPPTYKYEFDSDRYAGENLREPEKKRAPAWCDRILWLGKGIRQECYKRSEIRMSDHRPVTSIFNVGVEVFDHRKLQRALHVNNAAASAVHPEPSF
Type I inositol-1,4,5-trisphosphate 5-phosphatase 2
Refseq ID NP_567547
Protein GI 18415007
UniProt ID Q9FUR2
mRNA ID NM_117911
Length 646
RefSeq Status REVIEWED
MKTRRGKRPERFWPSIVMNKWLNRKPKVYDFSEDEIDTEPESEDDVCSVKDVPNVHCVTDEDSHNGRRGSEADHGNNISDGGVSVRGGYQRKHRRGKSETLRAQYINTKDIKVTVATWNVAGKRPSDDLEIEDWLSTDNPSDIYIIGFQEVVPLNAGNVFGAEDRGPIPKWESIIRRTLNKSNKESVYDQSPSCNNNALHRSHSAPSSPILAQEANSIISHVMVENLVADHSLDLATNEFIDAATALPSLEPQRNPNMDWPELALDSNPQIVGSEGKLRRVFSSNATLGFKLPENPSGASRFASEARQLKRSRSFETLNLSWNDIKEEIDNRSSSSSEAEEAAKIMHDDSSDGDSSSQDEEDGDKIRNSYGLPEDLVEECRKVKDSQKYVRIVSKQMVGIYVSVWIRRRLRRHVNNLKVSPVGVGLMGYMGNKGSVSISMTLYQSRMCFVCSHLTSGHKDGAEQRRNADVYEIIRRTRFASVLDTDQPRTIPCHDQVFWFGDLNYRLNMSDGEVRKLVSQKRWDELKNSDQLIRELRRGHVFDGWREGPIKFPPTYKYEFDSDRYAGENLREPEKKRAPAWCDRILWLGKGIRQECYKRSEIRMSDHRPVTSIFNVGVEVFDHRKLQRALHVNNAAASAVHPEPSF

Gene Information

Entrez Gene ID
827526
Gene Name
Type I inositol-1,4,5-trisphosphate 5-phosphatase 2
Gene Symbol
5PTASE2
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0052659 IEA:UniProtKB-EC F inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
GO:0052658 IEA:UniProtKB-EC F inositol-1,4,5-trisphosphate 5-phosphatase activity
GO:0004445 IDA:TAIR F inositol-polyphosphate 5-phosphatase activity
GO:0009738 IEA:UniProtKB-KW P abscisic acid-activated signaling pathway
GO:0046855 IDA:TAIR P inositol phosphate dephosphorylation
GO:0032957 IMP:TAIR P inositol trisphosphate metabolic process
GO:0046856 IEA:InterPro P phosphatidylinositol dephosphorylation
GO:0009737 IMP:TAIR P response to abscisic acid
GO:0009845 IMP:TAIR P seed germination

REACTOME Pathway Links

REACTOME Pathway ID Description
6254053 Rho GTPase cycle
6254054 Signaling by Rho GTPases
6254349 Synthesis of IP2, IP, and Ins in the cytosol
6254351 Synthesis of IP3 and IP4 in the cytosol

Domain Information

InterPro Annotations

Accession Description
IPR005135 Endonuclease/exonuclease/phosphatase
IPR000300 Inositol polyphosphate-related phosphatase

UniProt Annotations

Entry Information

Gene Name
Type I inositol-1,4,5-trisphosphate 5-phosphatase 2
Protein Entry
IP5P2_ARATH
UniProt ID
Q9FUR2
Species
Arabidopsis

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9FUR2-1; Sequence=Displayed; Name=2; IsoId=Q9FUR2-2; Sequence=VSP_013849; Note=No experimental confirmation available.;
Catalytic Activity 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H(2)O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate. {ECO:0000269|PubMed:11340187}.
Catalytic Activity D-myo-inositol 1,4,5-trisphosphate + H(2)O = myo-inositol 1,4-bisphosphate + phosphate. {ECO:0000269|PubMed:11340187}.
Function Seems to be involved in the abscisic acid (ABA) signaling pathway. Has phosphatase activity toward Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but not toward PtdIns(4,5)P2. {ECO:0000269|PubMed:11340187}.
Sequence Caution Sequence=CAA17144.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAB78803.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity Belongs to the inositol 1,4,5-trisphosphate 5- phosphatase type I family. {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011417 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18415007 RefSeq NP_567547 646 Type I inositol-1,4,5-trisphosphate 5-phosphatase 2
30684260 RefSeq NP_849402 613 Type I inositol-1,4,5-trisphosphate 5-phosphatase 2

Identical Sequences to LMP011417 proteins

Reference Database Accession Length Protein Name
GI:30684260 GenBank AEE83978.1 613 Type I inositol-1,4,5-trisphosphate 5-phosphatase 2 [Arabidopsis thaliana]
GI:18415007 GenBank AEE83979.1 646 Type I inositol-1,4,5-trisphosphate 5-phosphatase 2 [Arabidopsis thaliana]
GI:18415007 SwissProt Q9FUR2.2 646 RecName: Full=Type I inositol 1,4,5-trisphosphate 5-phosphatase 2; Short=At5PTase2 [Arabidopsis thaliana]

Related Sequences to LMP011417 proteins

Reference Database Accession Length Protein Name
GI:30684260 EMBL CAB59428.1 613 inositol-1,4,5-trisphosphate 5-Phosphatase [Arabidopsis thaliana]
GI:18415007 GenBank AAD10829.1 646 putative inositol polyphosphate 5-phosphatase At5P2 [Arabidopsis thaliana]
GI:30684260 GenBank AAD10829.1 646 putative inositol polyphosphate 5-phosphatase At5P2 [Arabidopsis thaliana]
GI:18415007 GenBank AAG17825.1 646 inositol polyphosphate 5-phosphatase II [Arabidopsis thaliana]
GI:30684260 GenBank AAG17825.1 646 inositol polyphosphate 5-phosphatase II [Arabidopsis thaliana]
GI:18415007 GenBank EFH44277.1 646 hypothetical protein ARALYDRAFT_914893 [Arabidopsis lyrata subsp. lyrata]
GI:18415007 GenBank AEE83978.1 613 Type I inositol-1,4,5-trisphosphate 5-phosphatase 2 [Arabidopsis thaliana]
GI:30684260 GenBank AEE83979.1 646 Type I inositol-1,4,5-trisphosphate 5-phosphatase 2 [Arabidopsis thaliana]
GI:30684260 RefSeq NP_567547.1 646 Type I inositol-1,4,5-trisphosphate 5-phosphatase 2 [Arabidopsis thaliana]
GI:18415007 RefSeq NP_849402.1 613 Type I inositol-1,4,5-trisphosphate 5-phosphatase 2 [Arabidopsis thaliana]
GI:18415007 RefSeq XP_002868018.1 646 hypothetical protein ARALYDRAFT_914893 [Arabidopsis lyrata subsp. lyrata]
GI:30684260 SwissProt Q9FUR2.2 646 RecName: Full=Type I inositol 1,4,5-trisphosphate 5-phosphatase 2; Short=At5PTase2 [Arabidopsis thaliana]