Gene/Proteome Database (LMPD)
LMPD ID
LMP011418
Gene ID
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
Type I inositol-1,4,5-trisphosphate 5-phosphatase CVP2
Gene Symbol
Synonyms
COTYLEDON VASCULAR PATTERN 2; CVP2; T25N20.12; T25N20_12
Alternate Names
Type I inositol-1,4,5-trisphosphate 5-phosphatase CVP2
Chromosome
1
EC Number
3.1.3.56
Summary
Encodes an inositol polyphosphate 5' phosphatase (5PTase) that is required for the proper recruitment of cells into developing vascular tissue in leaves and cotyledons. It is most similar to Type I 5PTases that are known to cleave a phosphate from IP3 or IP4. cvp2 mutants have elevated levels of IP3 and are hypersensitive to ABA in seed germination assays.
Orthologs
Proteins
| Type I inositol-1,4,5-trisphosphate 5-phosphatase CVP2 | |
|---|---|
| Refseq ID | NP_172038 |
| Protein GI | 240254013 |
| UniProt ID | Q9LR47 |
| mRNA ID | NM_100426 |
| Length | 617 |
| RefSeq Status | REVIEWED |
| MREEKSKTNKLAWSKKMVRKWFNIKSKTEEFQADDPSSAGIEVEHRSSFSAEKAPSTIKNTKTEKLSKNWEQQARQRRMNYENPRIIDVQNYSIFVATWNVAGRSPPSDLNLDEWLHSSAPADIYVLGFQEIVPLNAGNVLGAEDNGPAQKWLSLIRKTLNNRPGTSGTSGYHTPSPIPVPMAELDADFSGSTRQKNSTFFHRRSFQTPSSTWNDPSIPQPGLDRRFSVCDRVFFSHRPSDFDPSFRGSSSSHRPSDYSRRPSDYSRRPSDYSRRPSDYSRRPSDSRPSDYSRPSDYYSRPSDYSRPSDFSRSSDDDNGLGDSPSTVLYSPGSAANENGYRIPWNSSQYCLVASKQMVGVFLTIWVKSELREHVKNMKVSCVGRGLMGYLGNKGSISISMLLHQTSFCFVCTHLTSGQKEGDELKRNSDVMEILKKTRFPRVKSSEEEKSPENILQHDRVIWLGDLNYRIALSYRSAKALVEMQNWRALLENDQLRIEQKRGHVFKGWNEGKIYFPPTYKYSRNSDRYSGDDLHPKEKRRTPAWCDRILWFGEGLHQLSYVRGESRFSDHRPVYGIFCAEVESAHNRIKRTTSYSASRVQAEELLPYSRGYTELSFF | |
Gene Information
Entrez Gene ID
Gene Name
Type I inositol-1,4,5-trisphosphate 5-phosphatase CVP2
Gene Symbol
Species
Arabidopsis thaliana
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0052659 | IEA:UniProtKB-EC | F | inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity |
| GO:0052658 | IEA:UniProtKB-EC | F | inositol-1,4,5-trisphosphate 5-phosphatase activity |
| GO:0004445 | IEA:UniProtKB-EC | F | inositol-polyphosphate 5-phosphatase activity |
| GO:0046030 | IMP:TAIR | F | inositol trisphosphate phosphatase activity |
| GO:0009738 | IEA:UniProtKB-KW | P | abscisic acid-activated signaling pathway |
| GO:0030154 | IEA:UniProtKB-KW | P | cell differentiation |
| GO:0010588 | IMP:TAIR | P | cotyledon vascular tissue pattern formation |
| GO:0046855 | IMP:TAIR | P | inositol phosphate dephosphorylation |
| GO:0048016 | IC:TAIR | P | inositol phosphate-mediated signaling |
| GO:0032957 | IMP:TAIR | P | inositol trisphosphate metabolic process |
| GO:0010305 | IMP:TAIR | P | leaf vascular tissue pattern formation |
| GO:0046856 | IEA:InterPro | P | phosphatidylinositol dephosphorylation |
| GO:0010067 | IMP:TAIR | P | procambium histogenesis |
| GO:0009737 | IMP:TAIR | P | response to abscisic acid |
| GO:0010051 | IMP:TAIR | P | xylem and phloem pattern formation |
REACTOME Pathway Links
Domain Information
UniProt Annotations
Entry Information
Gene Name
Type I inositol-1,4,5-trisphosphate 5-phosphatase CVP2
Protein Entry
IP5P3_ARATH
UniProt ID
Species
Arabidopsis
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9LR47-1; Sequence=Displayed; Name=2; IsoId=Q9LR47-2; Sequence=VSP_037992, VSP_037993; Note=May be due to a competing donor splice site. No experimental confirmation available.; |
| Catalytic Activity | 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H(2)O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate. |
| Catalytic Activity | D-myo-inositol 1,4,5-trisphosphate + H(2)O = myo-inositol 1,4-bisphosphate + phosphate. |
| Developmental Stage | During early stages of embryogenesis, broadly expressed throughout globular and torpedo stages. At late torpedo stage, strongly expressed in developing vascular cells and weakly expressed in surrounding cells. By the walking-stick stage, restricted to incipient vascular cells of the apical loop, the midvein of the cotyledon and the root vasculature. In emerging leaves, strongly expressed in procambium and weakly expressed in areole cells. Limited to developing vascular cells in later stage of leaf development. In roots, expressed in procambium of the elongating zone and in immature vascular cells of the root differentiation zone. During inflorescence development, broadly expressed in young floral buds, and gradually restricted to procambium of cauline leaves, sepals, petals, gynoecia and anthers. {ECO:0000269|PubMed:15100402}. |
| Function | Required for the patterning of procambium and during the differentiation of vascular tissues. Acts before the acquisition of preprocambial identity. Seems to be also involved in the abscisic acid (ABA) signaling pathway. {ECO:0000269|PubMed:10559439, ECO:0000269|PubMed:15100402}. |
| Sequence Caution | Sequence=AAF79735.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BX816898; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305}; |
| Similarity | Belongs to the inositol 1,4,5-trisphosphate 5- phosphatase type I family. {ECO:0000305}. |
| Tissue Specificity | Broadly expressed in emerging organs. Mostly localized in procambium of growing organs. Restricted to vascular differentiating cells of young organs. {ECO:0000269|PubMed:15100402}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP011418 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 240254013 | RefSeq | NP_172038 | 617 | Type I inositol-1,4,5-trisphosphate 5-phosphatase CVP2 |
Identical Sequences to LMP011418 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:240254013 | GenBank | AEE27844.1 | 617 | Type I inositol-1,4,5-trisphosphate 5-phosphatase CVP2 [Arabidopsis thaliana] |
| GI:240254013 | SwissProt | Q9LR47.2 | 617 | RecName: Full=Type I inositol 1,4,5-trisphosphate 5-phosphatase CVP2; AltName: Full=Protein COTYLEDON VASCULAR PATTERN 2 [Arabidopsis thaliana] |
Related Sequences to LMP011418 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:240254013 | GenBank | AAF79735.1 | 609 | T25N20.12 [Arabidopsis thaliana] |
| GI:240254013 | GenBank | EOA39919.1 | 616 | hypothetical protein CARUB_v10008606mg [Capsella rubella] |
| GI:240254013 | RefSeq | XP_006307021.1 | 616 | hypothetical protein CARUB_v10008606mg [Capsella rubella] |
| GI:240254013 | RefSeq | XP_010485008.1 | 625 | PREDICTED: type I inositol 1,4,5-trisphosphate 5-phosphatase CVP2 [Camelina sativa] |
| GI:240254013 | RefSeq | XP_010475240.1 | 625 | PREDICTED: type I inositol 1,4,5-trisphosphate 5-phosphatase CVP2-like isoform X1 [Camelina sativa] |
| GI:240254013 | RefSeq | XP_010475241.1 | 625 | PREDICTED: type I inositol 1,4,5-trisphosphate 5-phosphatase CVP2-like isoform X2 [Camelina sativa] |