Gene/Proteome Database (LMPD)

LMPD ID
LMP011459
Gene ID
30076
Species
Danio rerio (Zebrafish)
Gene Name
vitamin D (1,25- dihydroxyvitamin D3) receptor a
Gene Symbol
vdra
Synonyms
vdr; VDRalpha
Alternate Names
vitamin D3 receptor A; VDR-A; NR1I1-A; vitamin D receptor a; vitamin D receptor alpha; 1,25-dihydroxyvitamin D3 receptor A; nuclear receptor subfamily 1 group I member 1-A
Chromosome
23

Proteins

vitamin D3 receptor A
Refseq ID NP_570994
Protein GI 18859543
UniProt ID Q9PTN2
mRNA ID NM_130919
Length 453
RefSeq Status PROVISIONAL
MLTENSAVNSGGKSKCEAGACESTVNGDATSLMDLMAVSTSATGQDQFDRNAPPICGVCGDKATGFHFNAMTCEGCKGFFRRSMKRKASFTCPFNGNCTITKDNRRHCQACRLKRCIDIGMMKEFILTDEEVQRKKDLIMKRKEEEAAREARKPRLSDEQMQIINSLVEAHHKTYDDSYSDFVRFRPPVREGPVTRSASRAASLHSLSDASSDSFNHSPESVDTKLNFSNLLMMYQDSGSPDSSEEDQQSRLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTAEDQIALLKSSAIEIIMLRSNQSFSLEDMSWSCGGPDFKYCINDVTKAGHTLELLEPLVKFQVGLKKLKLHEEEHVLLMAICLLSPDRPGVQDHVRIEALQDRLCDVLQAYIRIQHPGGRLLYAKMIQKLADLRSLNEEHSKQYRSLSFQPEHSMQLTPLVLEVFGSEVS

Gene Information

Entrez Gene ID
30076
Gene Name
vitamin D (1,25- dihydroxyvitamin D3) receptor a
Gene Symbol
vdra
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0008434 IEA:InterPro F calcitriol receptor activity
GO:0004879 IDA:ZFIN F ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0043565 IEA:InterPro F sequence-specific DNA binding
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0008134 IPI:ZFIN F transcription factor binding
GO:0005499 IDA:ZFIN F vitamin D binding
GO:0008270 IEA:InterPro F zinc ion binding
GO:0055074 IMP:ZFIN P calcium ion homeostasis
GO:0030522 IDA:GOC P intracellular receptor signaling pathway
GO:0001503 IMP:ZFIN P ossification
GO:0006355 IDA:ZFIN P regulation of transcription, DNA-templated
GO:0006351 IDA:ZFIN P transcription, DNA-templated

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001723 Steroid hormone receptor
IPR000324 Vitamin D receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
vitamin D (1,25- dihydroxyvitamin D3) receptor a
Protein Entry
VDRA_DANRE
UniProt ID
Q9PTN2
Species
Zebrafish

Comments

Comment Type Description
Domain Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Function Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Plays a central role in calcium homeostasis. {ECO:0000269|PubMed:17218092}.
Similarity Belongs to the nuclear hormone receptor family. NR1 subfamily. {ECO:0000305}.
Similarity Contains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular Location Nucleus.
Subunit Interacts with ncoa1 and possibly other coactivators, leading to a strong increase of transcription of target genes. {ECO:0000269|PubMed:17218092, ECO:0000269|PubMed:17346665}.
Tissue Specificity Detected in embryo 24 to 48 hours after fertilization and in gastrula. {ECO:0000269|PubMed:17997606}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011459 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18859543 RefSeq NP_570994 453 vitamin D3 receptor A

Identical Sequences to LMP011459 proteins

Reference Database Accession Length Protein Name
GI:18859543 GenBank AAF21427.1 453 vitamin D receptor [Danio rerio]

Related Sequences to LMP011459 proteins

Reference Database Accession Length Protein Name
GI:18859543 EMBL CAH04518.2 432 vitamin D receptor I [Cyprinus carpio]
GI:18859543 GenBank AAI62213.1 453 Vitamin D receptor a [Danio rerio]
GI:18859543 GenBank AAI62226.1 453 Vitamin D receptor a [Danio rerio]
GI:18859543 GenBank AIM62163.1 420 vitamin D receptor alpha [Danio rerio]
GI:18859543 RefSeq XP_007240874.1 470 PREDICTED: vitamin D3 receptor A-like [Astyanax mexicanus]
GI:18859543 SwissProt Q9PTN2.2 453 RecName: Full=Vitamin D3 receptor A; Short=VDR-A; AltName: Full=1,25-dihydroxyvitamin D3 receptor A; AltName: Full=Nuclear receptor subfamily 1 group I member 1-A [Danio rerio]