Gene/Proteome Database (LMPD)

LMPD ID
LMP011468
Gene ID
30311
Species
Danio rerio (Zebrafish)
Gene Name
eph-like kinase 1
Gene Symbol
ek1
Synonyms
rtk7; epha3; zgc:100780; etID309879.24
Alternate Names
ephrin type-A receptor 3; epha4d; eph-like receptor tyrosine kinase 7; tyrosine-protein kinase receptor ZEK1
Chromosome
24
EC Number
2.7.10.1

Proteins

ephrin type-A receptor 3 precursor
Refseq ID NP_571170
Protein GI 24308430
UniProt ID O13146
mRNA ID NM_131095
Length 981
RefSeq Status PROVISIONAL
MALFRIYSFLAPFHILVLCQALRNYPDNEVTLLDSMSAPGDLGWEAYPSEGWEEISVMDERNIPMRTYQVCNVMEANQNNWLRTGLIQREGAQRVYVEIKFTLRDCNSLPGVPGTCKETFNVYYHESNNAVAAPLRHIRESQYIKIDTIAADESFTQTDVGDRVMKLNTEVRDISGLSKRGLYLAFQDLGACIALVSVRVFYKRCPLAVLNLARFPDTVTGGDSALVEVRGTCVEDAEELEGPRMFCSADGGWLVPIGRCVCRPGFEEVDGHCQPCRSGFYKASAMDAYCVKCPPHSYSHQDKASECVCERGFYRAESDPRSMACTRPPSAPGNPISMVNETAVTLEWSPPRDSGGRGDVSYSVHCRKCSGETGASERCVPCGSGAHFNPRQFGLTHPRVLVTELQPHTNYTFSVEALNGVSDLSPSPRQLVSVNVTTSQTVSVILKERKGTDSVTLAWQGPEPVDGTVVEYEVTYYEKNQQDQNYTVLKTKSNSMTVDGLKPGTTYIFRVRARTDGGYGNYKGEIELETSHEDMLAVGDPNQQTILAISVAGGAVLLVLLVACFIVSGRRCGYIKAKQDPEEEKMQFQHGRVKLPETRTYIHPHTYEDPNQAVRDFAKEIEVSNIRIERVIGAGEFGEVCSGRLRLPSKREIQVAIKSLKAGYSEHQRRDFLSEASIMGQFDHPNIIRLEGVVTRCKPVMIVTEYMENGSLDTFLKKHDGQFTVIQLLGMLRGIAAGMQYLSEMNYVHRDLAARNILVNRNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAITYRKFTSASDVWSYGIVMWEVISYGERPYWEMSNQDVIKAVDEGYRLPAPMDCPVVLHQLMLDCWEKNRSDRPKFGQIVNTLDRLIRNPSSLKQLANSAVWEDPVTPEAAVNTVEDWLDLIKMGQYKEHFSSAGYVTLDSVLYVSSSELDKMGVELAGHQKKILSSIQCLQAHHGTQVQV

Gene Information

Entrez Gene ID
30311
Gene Name
eph-like kinase 1
Gene Symbol
ek1
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005769 ISS:UniProtKB C early endosome
GO:0005887 ISS:UniProtKB C integral component of plasma membrane
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0005004 ISS:UniProtKB F GPI-linked ephrin receptor activity
GO:0016477 ISS:UniProtKB P cell migration
GO:0048013 ISS:UniProtKB P ephrin receptor signaling pathway
GO:0097156 ISS:UniProtKB P fasciculation of motor neuron axon
GO:0097155 ISS:UniProtKB P fasciculation of sensory neuron axon
GO:0032319 ISS:UniProtKB P regulation of Rho GTPase activity
GO:0032956 ISS:UniProtKB P regulation of actin cytoskeleton organization
GO:0010717 ISS:UniProtKB P regulation of epithelial to mesenchymal transition
GO:0051893 ISS:UniProtKB P regulation of focal adhesion assembly
GO:0070507 ISS:UniProtKB P regulation of microtubule cytoskeleton organization

REACTOME Pathway Links

REACTOME Pathway ID Description
6176956 EPH-ephrin mediated repulsion of cells
6176955 EPHA-mediated growth cone collapse
6176652 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
6176653 Transcriptional regulation of pluripotent stem cells

Domain Information

InterPro Annotations

Accession Description
IPR001090 Ephrin receptor ligand binding domain
IPR016257 Ephrin receptor type-A /type-B
IPR027936 Ephrin receptor, transmembrane domain
IPR003961 Fibronectin type III
IPR008979 Galactose-binding domain-like
IPR013783 Immunoglobulin-like fold
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR000719 Protein kinase domain
IPR017441 Protein kinase, ATP binding site
IPR011009 Protein kinase-like domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001660 Sterile alpha motif domain
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR008266 Tyrosine-protein kinase, active site
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR001426 Tyrosine-protein kinase, receptor class V, conserved site

UniProt Annotations

Entry Information

Gene Name
eph-like kinase 1
Protein Entry
EPHA3_DANRE
UniProt ID
O13146
Species
Zebrafish

Comments

Comment Type Description
Catalytic Activity ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. {ECO:0000255|PROSITE- ProRule:PRU10028}.
Function Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially efna5. Upon activation by efna5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation probably through activation by efna1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development (By similarity). {ECO:0000250}.
Ptm Autophosphorylates upon activation by efna5. {ECO:0000250}.
Similarity Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. {ECO:0000255|PROSITE- ProRule:PRU00159}.
Similarity Contains 1 Eph LBD (Eph ligand-binding) domain. {ECO:0000255|PROSITE-ProRule:PRU00883}.
Similarity Contains 1 SAM (sterile alpha motif) domain. {ECO:0000255|PROSITE-ProRule:PRU00184}.
Similarity Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
Similarity Contains 2 fibronectin type-III domains. {ECO:0000255|PROSITE-ProRule:PRU00316}.
Subcellular Location Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Subunit Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). {ECO:0000250}.
Tissue Specificity Widely expressed in the developing zebrafish nervous system.

Identical and Related Proteins

Unique RefSeq proteins for LMP011468 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
24308430 RefSeq NP_571170 981 ephrin type-A receptor 3 precursor

Identical Sequences to LMP011468 proteins

Reference Database Accession Length Protein Name
GI:24308430 GenBank AAC60220.1 981 Zek1 [Danio rerio]
GI:24308430 SwissProt O13146.1 981 RecName: Full=Ephrin type-A receptor 3; AltName: Full=EPH-like kinase 1; AltName: Full=Tyrosine-protein kinase receptor ZEK1; Flags: Precursor [Danio rerio]

Related Sequences to LMP011468 proteins

Reference Database Accession Length Protein Name
GI:24308430 GenBank AAI62500.1 981 Eph-like kinase 1 [Danio rerio]
GI:24308430 RefSeq NP_705944.1 976 eph receptor A4b precursor [Danio rerio]
GI:24308430 RefSeq XP_005162850.1 946 PREDICTED: ephrin type-A receptor 3 isoform X1 [Danio rerio]
GI:24308430 RefSeq XP_006637746.1 939 PREDICTED: ephrin type-A receptor 3-like [Lepisosteus oculatus]
GI:24308430 RefSeq XP_007233701.1 991 PREDICTED: ephrin type-A receptor 3-like isoform X1 [Astyanax mexicanus]
GI:24308430 RefSeq XP_009296995.1 976 PREDICTED: eph receptor A4b isoform X1 [Danio rerio]