Gene/Proteome Database (LMPD)

LMPD ID
LMP011474
Gene ID
30418
Species
Danio rerio (Zebrafish)
Gene Name
nuclear receptor subfamily 2, group F, member 1a
Gene Symbol
nr2f1a
Synonyms
nr2f1; svp44; couptf6; fc10d05; COUP(VI); wu:fc10d05
Alternate Names
nuclear receptor subfamily 2 group F member 1-A; svp[44]; zSvp[44]; zCOUP-TFI; etID309751.5; COUPTFalpha-A; COUP-TFalpha-A; seven-up related 44; COUP transcription factor 1-A; steroid receptor homolog SVP 44; nuclear receptor subfamily 2, group F, member 1
Chromosome
5

Proteins

nuclear receptor subfamily 2 group F member 1-A
Refseq ID NP_571255
Protein GI 20589472
UniProt ID Q06725
mRNA ID NM_131180
Length 411
RefSeq Status PROVISIONAL
MAMVVSVWRDPQEDVAGGPPSGPNPAAQPAREQQQAASAAPHTPQTPSQPGPPSTPGTAGDKGSQNSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAEPYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCIKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMSIQ

Gene Information

Entrez Gene ID
30418
Gene Name
nuclear receptor subfamily 2, group F, member 1a
Gene Symbol
nr2f1a
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0004879 IEA:InterPro F ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0043565 IEA:InterPro F sequence-specific DNA binding
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0008270 IEA:InterPro F zinc ion binding

REACTOME Pathway Links

REACTOME Pathway ID Description
6176174 Generic Transcription Pathway
6176482 Nuclear Receptor transcription pathway

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001723 Steroid hormone receptor
IPR003068 Transcription factor COUP
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
nuclear receptor subfamily 2, group F, member 1a
Protein Entry
N2F1A_DANRE
UniProt ID
Q06725
Species
Zebrafish

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q06725-1; Sequence=Displayed; Name=2; IsoId=Q06725-2; Sequence=VSP_036606; Note=No experimental confirmation available.; Name=3; IsoId=Q06725-3; Sequence=VSP_036605; Note=No experimental confirmation available.;
Function Putative transcription factor that is required in photoreceptor cells precursors during eye development. {ECO:0000269|PubMed:8467797}.
Similarity Belongs to the nuclear hormone receptor family. NR2 subfamily. {ECO:0000305}.
Similarity Contains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}.
Tissue Specificity First expressed in 11-12 hour embryos. In the rostral brain of 13 hour embryos, expressed within the anterior half of the midbrain and the posterior part of the diencephalon. In the presumptive hindbrain, expressed in a segment-like stripe in the anterior region, resembling the presumptive rhombomere units of the hindbrain. Also detected in the intermediate mesoderm, posterior to the first somite. As somitogenesis proceeds, expression extends posteriorly and flanks the 10 most anterior somites. Expression changes extensively both in level and expansion of domains between 13 and 20 hours. In the rostral brain, expression extends to include a major part of the diencephalon and a caudal portion of the telencephalon. Within the hindbrain, strongly expressed in the two most anterior rhombomeres, and a lower but uniform expression is seen to extend throughout rhombomere 7. In 28 hour embryos, higher and more uniform expression is seen in both rostral and hindbrain areas. Also expressed in the retina of the eye. {ECO:0000269|PubMed:17997606, ECO:0000269|PubMed:8467797, ECO:0000269|PubMed:8541212}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011474 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
20589472 RefSeq NP_571255 411 nuclear receptor subfamily 2 group F member 1-A

Identical Sequences to LMP011474 proteins

Reference Database Accession Length Protein Name
GI:20589472 EMBL CAA49780.1 411 svp 44 [Danio rerio]
GI:20589472 GenBank AAH66671.1 411 Nuclear receptor subfamily 2, group F, member 1a [Danio rerio]
GI:20589472 SwissProt Q06725.1 411 RecName: Full=Nuclear receptor subfamily 2 group F member 1-A; AltName: Full=COUP transcription factor 1-A; Short=COUP-TFalpha-A; Short=zCOUP-TFI; AltName: Full=Seven-up related 44; Short=Svp[44]; Short=zSvp[44]; AltName: Full=Steroid receptor homolog SVP 44 [Danio rerio]

Related Sequences to LMP011474 proteins

Reference Database Accession Length Protein Name
GI:20589472 GenBank AAH56574.1 410 Nuclear receptor subfamily 2, group F, member 1a [Danio rerio]
GI:20589472 RefSeq XP_005165564.1 410 PREDICTED: nuclear receptor subfamily 2 group F member 1-A isoform X1 [Danio rerio]
GI:20589472 RefSeq XP_005803556.1 411 PREDICTED: nuclear receptor subfamily 2 group F member 1-A-like isoform X2 [Xiphophorus maculatus]
GI:20589472 RefSeq XP_007562803.1 411 PREDICTED: COUP transcription factor 1 [Poecilia formosa]
GI:20589472 RefSeq XP_008286881.1 411 PREDICTED: COUP transcription factor 1 [Stegastes partitus]
GI:20589472 RefSeq XP_008417144.1 411 PREDICTED: COUP transcription factor 1 [Poecilia reticulata]