Gene/Proteome Database (LMPD)
LMPD ID
LMP011476
Gene ID
Species
Danio rerio (Zebrafish)
Gene Name
retinoid x receptor, gamma a
Gene Symbol
Synonyms
RXR; rxra; rxrg; NR2B1
Alternate Names
retinoic acid receptor RXR-gamma-A; NR2B3; retinoid receptor-alpha; retinoid X receptor alpha; retinoid x receptor, alpha; retinoid X receptor gamma-A; retinoic acid receptor RXR-alpha; nuclear receptor subfamily 2 group B member 3-A
Chromosome
2
Proteins
| retinoic acid receptor RXR-gamma-A | |
|---|---|
| Refseq ID | NP_571292 |
| Protein GI | 41282088 |
| UniProt ID | Q90416 |
| mRNA ID | NM_131217 |
| Length | 441 |
| RefSeq Status | PROVISIONAL |
| MDNNDTYLHLSSSLQVAHGHLSSPPSQPPLSSMVSHHHPSIINGLGSPYSVITSSSLGSPSASMPTTSNMGYGALNSPQMNSLNSVSSSEDIKPPPGLAGLGSYPCGSPGSLSKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYTCRDNKDCQIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGRERSDNEVDSSSSFNEEMPVEKILDAELAVEPKTEAYMESSMSNSTNDPVTNICQAADKQLFTLVEWAKRIPHFSDLPLDDQVILLRAGWNELLIASFSHRSVTVKDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDAKGLSNPSEVEALREKVYASLEGYTKHNYPDQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQIT | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005634 | IEA:UniProtKB-KW | C | nucleus |
| GO:0004886 | IDA:UniProtKB | F | 9-cis retinoic acid receptor activity |
| GO:0043565 | IEA:InterPro | F | sequence-specific DNA binding |
| GO:0003700 | IDA:UniProtKB | F | sequence-specific DNA binding transcription factor activity |
| GO:0003707 | IEA:InterPro | F | steroid hormone receptor activity |
| GO:0008270 | IEA:InterPro | F | zinc ion binding |
| GO:0045893 | IDA:UniProtKB | P | positive regulation of transcription, DNA-templated |
| GO:0045944 | IDA:UniProtKB | P | positive regulation of transcription from RNA polymerase II promoter |
| GO:0048384 | IDA:GOC | P | retinoic acid receptor signaling pathway |
KEGG Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR021780 | Nuclear/hormone receptor activator site AF-1 |
| IPR008946 | Nuclear hormone receptor, ligand-binding |
| IPR000536 | Nuclear hormone receptor, ligand-binding, core |
| IPR000003 | Retinoid X receptor/HNF4 |
| IPR001723 | Steroid hormone receptor |
| IPR013088 | Zinc finger, NHR/GATA-type |
| IPR001628 | Zinc finger, nuclear hormone receptor-type |
UniProt Annotations
Entry Information
Gene Name
retinoid x receptor, gamma a
Protein Entry
RXRGA_DANRE
UniProt ID
Species
Zebrafish
Comments
| Comment Type | Description |
|---|---|
| Developmental Stage | Expressed both maternally and zygotically. {ECO:0000269|PubMed:16448862, ECO:0000269|PubMed:17195188, ECO:0000269|PubMed:7565671}. |
| Domain | Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. |
| Function | Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for rxrs is 9-cis retinoic acid (By similarity). {ECO:0000250}. |
| Similarity | Belongs to the nuclear hormone receptor family. NR2 subfamily. {ECO:0000305}. |
| Similarity | Contains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}. |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}. |
| Subunit | Homodimer (By similarity). Heterodimer; with a rar molecule (By similarity). Binds DNA preferentially as a rar/rxr heterodimer (By similarity). Heterodimerizes with rarga. {ECO:0000250}. |
| Tissue Specificity | Uniformly expressed from the blastula to mid- gastrula stages. In late gastrula stages, there is specific expression in the presumptive hindbrain and spinal cord. At 16 hours post-fertilization (hpf), expressed in the hindbrain from rhombomere 7/8 to the anterior spinal cord; this expression continues until 42 hpf. At 24 hpf, also expressed in the lateral plate mesoderm flanking rhombomere 6 and in the cranial neural crest, but not in the migrating crest. At 26 hpf, also expressed in retina. At 48 hpf, strong retinal expression. {ECO:0000269|PubMed:17195188, ECO:0000269|PubMed:7565671}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP011476 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 41282088 | RefSeq | NP_571292 | 441 | retinoic acid receptor RXR-gamma-A |
Identical Sequences to LMP011476 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:41282088 | GenBank | AAH59576.1 | 441 | Retinoid x receptor, gamma a [Danio rerio] |
| GI:41282088 | SwissProt | Q90416.2 | 441 | RecName: Full=Retinoic acid receptor RXR-gamma-A; AltName: Full=Nuclear receptor subfamily 2 group B member 3-A; AltName: Full=Retinoic acid receptor RXR-alpha; AltName: Full=Retinoid X receptor alpha; AltName: Full=Retinoid X receptor gamma-A [Danio rerio] |
Related Sequences to LMP011476 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:41282088 | GenBank | AAC59720.1 | 441 | retinoid X receptor alpha [Danio rerio] |
| GI:41282088 | PRF | - | 441 | retinoid X receptor:ISOTYPE=alpha [Danio rerio] |
| GI:41282088 | RefSeq | XP_004068390.1 | 455 | PREDICTED: retinoic acid receptor RXR-gamma-B [Oryzias latipes] |
| GI:41282088 | RefSeq | XP_007245492.1 | 460 | PREDICTED: retinoic acid receptor RXR-gamma-B-like isoform X1 [Astyanax mexicanus] |
| GI:41282088 | RefSeq | XP_007245493.1 | 454 | PREDICTED: retinoic acid receptor RXR-gamma-B-like isoform X2 [Astyanax mexicanus] |
| GI:41282088 | RefSeq | XP_007558779.1 | 453 | PREDICTED: retinoic acid receptor RXR-gamma-B isoform X2 [Poecilia formosa] |