Gene/Proteome Database (LMPD)
Proteins
| retinoic acid receptor RXR-beta-B | |
|---|---|
| Refseq ID | NP_571313 |
| Protein GI | 18859343 |
| UniProt ID | Q90417 |
| mRNA ID | NM_131238 |
| Length | 422 |
| RefSeq Status | PROVISIONAL |
| MNSLPPSTSAVSSPVSSVDSPLSAVSSSIGSPGVPGTPSIGYGPISNSQINSSMSVSRLHAVSSSDDVKPPFGLKSVSGSGPMLSQKRMCAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLSYTCRDNKECLVDKRQRNRCQYCRYQKCLAMGMKREAVQEERQKNKERDGDYECSSSANEEMPVEKILEAETAVEHRTDLHSDATGSPNDPVTNICQAADKQLFTLVEWAKRVPHFSDVPLDDQVILLRAGWNELLIAAFSHRSISVKDEILLATGLHVPKESTHNLGVEAFFDRESSHSAEVGALFDRVLTELVCKMRDMQMDKTELGCLRAIVLFNPDAKGLTSSSEVELLREKVYASLESYCKQKYPDQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGNTPIDTFLMEMLESPH | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005634 | IEA:UniProtKB-KW | C | nucleus |
| GO:0004886 | NAS:UniProtKB | F | 9-cis retinoic acid receptor activity |
| GO:0043565 | IEA:InterPro | F | sequence-specific DNA binding |
| GO:0003707 | IEA:InterPro | F | steroid hormone receptor activity |
| GO:0008270 | IEA:InterPro | F | zinc ion binding |
| GO:0045892 | IDA:UniProtKB | P | negative regulation of transcription, DNA-templated |
| GO:0006359 | IDA:GOC | P | regulation of transcription from RNA polymerase III promoter |
| GO:0048384 | NAS:GOC | P | retinoic acid receptor signaling pathway |
| GO:0006383 | IDA:GOC | P | transcription from RNA polymerase III promoter |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR021780 | Nuclear/hormone receptor activator site AF-1 |
| IPR008946 | Nuclear hormone receptor, ligand-binding |
| IPR000536 | Nuclear hormone receptor, ligand-binding, core |
| IPR000003 | Retinoid X receptor/HNF4 |
| IPR001723 | Steroid hormone receptor |
| IPR013088 | Zinc finger, NHR/GATA-type |
| IPR001628 | Zinc finger, nuclear hormone receptor-type |
UniProt Annotations
Entry Information
Gene Name
retinoid x receptor, beta b
Protein Entry
Q90417_DANRE
UniProt ID
Species
Zebrafish
Comments
| Comment Type | Description |
|---|---|
| Developmental Stage | Expressed both maternally and zygotically. |
| Domain | Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. |
| Function | Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for rxrs is 9-cis retinoic acid (By similarity). |
| Similarity | Belongs to the nuclear hormone receptor family. NR2 subfamily. |
| Similarity | Contains 1 nuclear receptor DNA-binding domain. |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}. |
| Subunit | Homodimer (By similarity). Heterodimer; with a rar molecule (By similarity). Binds DNA preferentially as a rar/rxr heterodimer (By similarity). Heterodimerizes with rarga. |
| Tissue Specificity | Shows uniform expression from the blastula to mid-gastrula stages. At 12 hours post-fertilization (hpf), expressed ubiquitously but more weakly. At 24 hpf, restricted to the ventral diencephalon, pharangeal endoderm and trunk and tail mesoderm; mesoderm expression is in medial cells of each somite along the dorsoventral axis, forming stripes. At 48 hpf, expressed in forebrain, eye, midbrain and anterior hindbrain. |
Identical and Related Proteins
Unique RefSeq proteins for LMP011477 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 18859343 | RefSeq | NP_571313 | 422 | retinoic acid receptor RXR-beta-B |
Identical Sequences to LMP011477 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:18859343 | GenBank | AAC59721.1 | 422 | retinoid X receptor delta [Danio rerio] |
| GI:18859343 | PRF | - | 422 | retinoid X receptor:ISOTYPE=delta [Danio rerio] |
| GI:18859343 | SwissProt | Q90417.1 | 422 | RecName: Full=Retinoic acid receptor RXR-beta-B; AltName: Full=Nuclear receptor subfamily 2 group B member 2-B; AltName: Full=Retinoic acid receptor RXR-delta; AltName: Full=Retinoid X receptor beta-B; AltName: Full=Retinoid X receptor delta [Danio rerio] |
Related Sequences to LMP011477 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:18859343 | GenBank | ABQ01987.1 | 430 | retinoid X receptor beta [Salmo salar] |
| GI:18859343 | GenBank | ABQ59675.1 | 430 | RXR [Salmo salar] |
| GI:18859343 | RefSeq | XP_005159468.1 | 463 | PREDICTED: retinoic acid receptor RXR-beta-A isoform X6 [Danio rerio] |
| GI:18859343 | RefSeq | XP_007241172.1 | 423 | PREDICTED: retinoic acid receptor RXR-beta-B-like [Astyanax mexicanus] |
| GI:18859343 | RefSeq | XP_007253125.1 | 463 | PREDICTED: retinoic acid receptor RXR-beta-A-like isoform X3 [Astyanax mexicanus] |
| GI:18859343 | RefSeq | XP_009292298.1 | 472 | PREDICTED: retinoic acid receptor RXR-beta-A isoform X3 [Danio rerio] |