Gene/Proteome Database (LMPD)
LMPD ID
LMP011481
Gene ID
Species
Danio rerio (Zebrafish)
Gene Name
retinoic acid receptor gamma a
Gene Symbol
Synonyms
rarg; NR1B3; rarg2; wu:fb01e02; wu:fb01f03; wu:fc35a09; etID33387.23; etID309710.23
Alternate Names
retinoic acid receptor gamma-A; NR1B3-A; RAR gamma; RARgamma-A; zRAR gamma; RAR-gamma-2; RAR-gamma-A; zRAR-gamma-2; retinoic acid receptor gamma-2; nuclear receptor subfamily 1 group B member 3-A
Chromosome
23
Proteins
| retinoic acid receptor gamma-A | |
|---|---|
| Refseq ID | NP_571414 |
| Protein GI | 24308525 |
| UniProt ID | Q91392 |
| mRNA ID | NM_131339 |
| Length | 499 |
| RefSeq Status | PROVISIONAL |
| MFDCMEALGMGPRQLYDVTNRGACMLRKASPFYAGLDPFAWTGTASVRSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCQDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCQINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKDVKDEVIPPESYELSGELEELVNKVSKAHQETFPSLCQLGKYTTNSSSDHRIQLDLGLWDKFSELSTKCIIKIVEFAKRLPGFTTLTIADQITLLKSACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPERVDRLQEPLLEALKIYARRRRPNKPHMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEAFEDQSEATEKKPEPEPPAPPPPALLTMKKEQEDEDDSWATENGSEPSPEEEDDDDEDGEEERGTDSDGEAWGGQEPNADVSRKSHGGRAQ | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005634 | IEA:UniProtKB-KW | C | nucleus |
| GO:0003677 | IDA:UniProtKB | F | DNA binding |
| GO:0003708 | IEA:InterPro | F | retinoic acid receptor activity |
| GO:0043565 | IEA:InterPro | F | sequence-specific DNA binding |
| GO:0003707 | IEA:InterPro | F | steroid hormone receptor activity |
| GO:0008270 | IEA:InterPro | F | zinc ion binding |
| GO:0060037 | IDA:UniProtKB | P | pharyngeal system development |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 6176482 | Nuclear Receptor transcription pathway |
Domain Information
InterPro Annotations
UniProt Annotations
Entry Information
Gene Name
retinoic acid receptor gamma a
Protein Entry
RARGA_DANRE
UniProt ID
Species
Zebrafish
Comments
| Comment Type | Description |
|---|---|
| Developmental Stage | Expressed zygotically, with greatest expression at 24 hours post-fertilization (hpf). At 9 hpf, shows ubiquitous expression in the epiblast. At 10 hpf, expressed in anterior and posterior regions; not expressed in the presumptive hindbrain, and anterior expression is limited to mesoderm adjacent to the head. Between 11-15 hpf restricted expression in the cranial mesoderm and tailbud. At 12 hpf, expressed in anterior lateral mesenchyme, with strongest expression lateral to the future hindbrain, and in tailbud. At 24 hpf, also expressed in the hindbrain, neural crest cells and tail; not detected in spinal cord. At 48 hpf, hindbrain expression increases with an anterior border at rhombomere 3 and a posterior border at the spinal cord/hindbrain junction; expressed in stripes one rhombomere wide in dorsal hindbrain. At 48 hpf, also expressed in pharangeal arches 1-7, anterior neurocranium, cells separating the eyes and forebrain, pectoral fin buds and tailbud. Embryonic zygotic expression overlaps that of raraa and rarab, but there is stronger expression in the posterior hindbrain beginning in late somitogenesis, and in neural crest cells in the pharangeal arches. In the adult, strongly expressed in the ovary, brain and muscle, and weakly expressed in the liver and digestive tract. {ECO:0000269|PubMed:16455309, ECO:0000269|PubMed:17195188, ECO:0000269|PubMed:18929555, ECO:0000269|PubMed:7918098}. |
| Domain | Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. |
| Function | Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development and for the development of pharyngeal arches. {ECO:0000250, ECO:0000269|PubMed:18929555}. |
| Induction | By retinoic acid, in embryonic anterior brain and eye. {ECO:0000269|PubMed:18929555, ECO:0000269|PubMed:7918098}. |
| Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. {ECO:0000305}. |
| Similarity | Contains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}. |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}. |
| Subunit | Heterodimer; with an rxr molecule. Binds DNA preferentially as a rar/rxr heterodimer. {ECO:0000250}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP011481 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 24308525 | RefSeq | NP_571414 | 499 | retinoic acid receptor gamma-A |
Identical Sequences to LMP011481 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:24308525 | GenBank | AAB32277.1 | 499 | retinoic acid receptor gamma [Danio rerio] |
Related Sequences to LMP011481 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:24308525 | GenBank | AAH98519.1 | 499 | Retinoic acid receptor gamma a [Danio rerio] |
| GI:24308525 | GenBank | AEU04705.1 | 501 | retinoic acid receptor gamma [Lateolabrax japonicus] |
| GI:24308525 | RefSeq | XP_005813247.1 | 503 | PREDICTED: retinoic acid receptor gamma-A-like [Xiphophorus maculatus] |
| GI:24308525 | RefSeq | XP_007556622.1 | 501 | PREDICTED: retinoic acid receptor gamma isoform X2 [Poecilia formosa] |
| GI:24308525 | RefSeq | XP_008286515.1 | 500 | PREDICTED: retinoic acid receptor gamma isoform X2 [Stegastes partitus] |
| GI:24308525 | SwissProt | Q91392.2 | 499 | RecName: Full=Retinoic acid receptor gamma-A; Short=RAR-gamma-A; Short=zRAR gamma; AltName: Full=Nuclear receptor subfamily 1 group B member 3-A; AltName: Full=RAR-gamma-2 [Danio rerio] |