Gene/Proteome Database (LMPD)
LMPD ID
LMP011482
Gene ID
Species
Danio rerio (Zebrafish)
Gene Name
thyroid hormone receptor beta
Gene Symbol
Synonyms
trb; NR1A2; TR[b]1; TR-beta; fj24f03; wu:fj24f03
Alternate Names
thyroid hormone receptor beta; TRbeta1; thyroid hormone receptor beta 1; thyroid hormone receptor beta 2; thyroid hormone receptor beta-1; nuclear receptor subfamily 1 group A member 2
Chromosome
19
Proteins
| thyroid hormone receptor beta | |
|---|---|
| Refseq ID | NP_571415 |
| Protein GI | 18859511 |
| UniProt ID | Q9PVE4 |
| mRNA ID | NM_131340 |
| Length | 386 |
| RefSeq Status | PROVISIONAL |
| MSEQADKCNSRWKDEAMQNGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLNPTYACKYEGKCVIDKVTRNQCQECRFKKCIAVGMATDLVLDDSKRLAKRKLIEENRERRRREELQKTVWDRPEPTQEEWEMIRVVTEAHMATNAQGNHWKQKRKFLPEDIGSAPIVNAPEGNKVDIEAFSQFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGVSLSSFNLDDSEVALLQAVILLSSDRPGLTSVERIERCQEEFLLAFEHYINYRKHKVAHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005634 | IEA:UniProtKB-KW | C | nucleus |
| GO:0043565 | IEA:InterPro | F | sequence-specific DNA binding |
| GO:0003707 | IEA:InterPro | F | steroid hormone receptor activity |
| GO:0070324 | ISS:UniProtKB | F | thyroid hormone binding |
| GO:0004887 | ISS:UniProtKB | F | thyroid hormone receptor activity |
| GO:0008270 | IEA:InterPro | F | zinc ion binding |
| GO:0030522 | ISS:GOC | P | intracellular receptor signaling pathway |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| dre04080 | Neuroactive ligand-receptor interaction |
REACTOME Pathway Links
Domain Information
InterPro Annotations
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9PVE4-1; Sequence=Displayed; Name=2; IsoId=Q9PVE4-2; Sequence=VSP_035801; |
| Caution | In contrast to PubMed:10687864 and PubMed:11963654, PubMed:17418841 found that triiodothyronine (T3) did not induce expression in the embryo. {ECO:0000305}. |
| Developmental Stage | Expressed both maternally and zygotically. Expressed at the 1 cell stage (0 hpf) but disappears by the 2 cell stage. Expressed again from the 16 cell stage onwards. Embryonic expression increases dramatically around the hatching period. High expression then continues until 6 dpf, before declining. {ECO:0000269|PubMed:10687864, ECO:0000269|PubMed:11963654, ECO:0000269|PubMed:17418841}. |
| Domain | Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. |
| Function | Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for the thyroid gland hormone triiodothyronine (T3). Transactivating activity is ligand-dependent, and is repressed in the absence of T3. {ECO:0000269|PubMed:10687864}. |
| Induction | By triiodothyronine (T3) and L-thyroxine (T4). {ECO:0000269|PubMed:10687864, ECO:0000269|PubMed:11963654}. |
| Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. {ECO:0000305}. |
| Similarity | Contains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}. |
| Subcellular Location | Nucleus. |
| Subunit | Interacts (via the ligand-binding domain) with ncoa2. {ECO:0000269|PubMed:18248177}. |
| Tissue Specificity | Widely expressed in a range of adult tissues including the brain, eye, fin, gill, intestine, liver, swim bladder and ovary. In the eye, expressed in the outer nuclear layer of the retina. {ECO:0000269|PubMed:10687864, ECO:0000269|PubMed:17997606}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP011482 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 18859511 | RefSeq | NP_571415 | 386 | thyroid hormone receptor beta |
Identical Sequences to LMP011482 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:18859511 | GenBank | AAF14239.1 | 386 | thyroid hormone receptor beta 1 [Danio rerio] |
| GI:18859511 | GenBank | AAI63114.1 | 386 | Thyroid hormone receptor beta [Danio rerio] |
| GI:18859511 | GenBank | AAI63106.1 | 386 | Thyroid hormone receptor beta [Danio rerio] |
Related Sequences to LMP011482 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:18859511 | RefSeq | XP_009292427.1 | 415 | PREDICTED: thyroid hormone receptor beta isoform X4 [Danio rerio] |
| GI:18859511 | RefSeq | XP_009292428.1 | 415 | PREDICTED: thyroid hormone receptor beta isoform X4 [Danio rerio] |
| GI:18859511 | RefSeq | XP_009292429.1 | 415 | PREDICTED: thyroid hormone receptor beta isoform X4 [Danio rerio] |
| GI:18859511 | RefSeq | XP_009292430.1 | 415 | PREDICTED: thyroid hormone receptor beta isoform X4 [Danio rerio] |
| GI:18859511 | RefSeq | XP_009292431.1 | 415 | PREDICTED: thyroid hormone receptor beta isoform X4 [Danio rerio] |
| GI:18859511 | SwissProt | Q9PVE4.2 | 395 | RecName: Full=Thyroid hormone receptor beta; Short=TR-beta; Short=TRb; AltName: Full=Nuclear receptor subfamily 1 group A member 2; AltName: Full=Thyroid hormone receptor beta-1; Short=TRbeta1 [Danio rerio] |