Gene/Proteome Database (LMPD)

LMPD ID
LMP011487
Gene ID
30705
Species
Danio rerio (Zebrafish)
Gene Name
fibroblast growth factor receptor 1a
Gene Symbol
fgfr1a
Synonyms
cb231; fgfr1; sb:cb231
Alternate Names
fibroblast growth factor receptor 1-A; FGFR-1-A; bFGF-R-1-A; fibroblast growth factor receptor 1; basic fibroblast growth factor receptor 1-A
Chromosome
8
EC Number
2.7.10.1

Proteins

fibroblast growth factor receptor 1-A precursor
Refseq ID NP_694494
Protein GI 23308617
UniProt ID Q90Z00
mRNA ID NM_152962
Length 806
RefSeq Status PROVISIONAL
MIMKTTLLLISVLLTQALQSQGRPAIQDEAPAEPTSYTLDSGEKLELSCKAKEDTQKVTWTKDLVPLVDGEHTRLRNDQMEIEKVEPADSGLYACFAQGLNSNHTEYFNISVTDEEDEVDSSSEEAKLSNDQNLPMAPVWAQPDKMEKKLHAVPASKTVKFRCQANGNPTPTLKWLKNGKEFKRDQRIGGFKVREHMWTIIMESVVPSDRGNYTCLVENRHGSINHTYQLDVVERSPHRPILQAGLPANRTAVVGSDVEFECKVFSDPQPHIQWLKHIEVNGSRYGPDGLPYVRALKTAGVNTTDKEMEVLQIRNVSLEDAGEYTCLAGNSIGHSHHSAWLTVYKAVPPTQLPNQTYLEVLIYCVGFFLICVMVGTAVLAKMHSSAKKSDFNSQLAVHKLAKSIPLRRQVTVSVDSSSSMHSGGMLVRPSRLSSSGSPMLSGVSEYELPQDPRWEVQRDRLVLGKPLGEGCFGQVMMAEAMGMDKEKPNRITKVAVKMLKSDATEKDLSDLISEMEMMKIIGKHKNIINLLGACTQDGPLYVIVEFAAKGNLREYLRVRRPPGMEYCYNPDQVPVENMSIKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDRPSTCTHELYMMMRDCWHAVPSQRPTFKQLVEDLDRTLSMTSNQEYLDLSVSLDQFSPNFPDTRSSTCSSGEDSVFSHDAGADEPCLPKFPPHPNRGVAFKKR

Gene Information

Entrez Gene ID
30705
Gene Name
fibroblast growth factor receptor 1a
Gene Symbol
fgfr1a
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0031410 IEA:UniProtKB-KW C cytoplasmic vesicle
GO:0005887 ISS:ZFIN C integral component of plasma membrane
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0005886 ISS:UniProtKB C plasma membrane
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0017134 ISS:UniProtKB F fibroblast growth factor binding
GO:0005007 IDA:ZFIN F fibroblast growth factor-activated receptor activity
GO:0008201 ISS:UniProtKB F heparin binding
GO:0060249 IMP:ZFIN P anatomical structure homeostasis
GO:0048738 IMP:ZFIN P cardiac muscle tissue development
GO:0009953 IMP:ZFIN P dorsal/ventral pattern formation
GO:0008543 IDA:ZFIN P fibroblast growth factor receptor signaling pathway
GO:0031101 IMP:ZFIN P fin regeneration
GO:0001889 IMP:ZFIN P liver development
GO:0042664 IGI:ZFIN P negative regulation of endodermal cell fate specification
GO:0018108 ISS:UniProtKB P peptidyl-tyrosine phosphorylation
GO:0043406 ISS:UniProtKB P positive regulation of MAP kinase activity
GO:0008284 IEA:InterPro P positive regulation of cell proliferation
GO:0010863 ISS:UniProtKB P positive regulation of phospholipase C activity
GO:0036342 IGI:ZFIN P post-anal tail morphogenesis
GO:0048916 IMP:ZFIN P posterior lateral line development
GO:0043589 IMP:ZFIN P skin morphogenesis

KEGG Pathway Links

KEGG Pathway ID Description
dre04520 Adherens junction
dre04010 MAPK signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR028174 Fibroblast growth factor receptor 1/4
IPR016248 Fibroblast growth factor receptor family
IPR013098 Immunoglobulin I-set
IPR003598 Immunoglobulin subtype 2
IPR007110 Immunoglobulin-like domain
IPR013783 Immunoglobulin-like fold
IPR000719 Protein kinase domain
IPR017441 Protein kinase, ATP binding site
IPR011009 Protein kinase-like domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR008266 Tyrosine-protein kinase, active site
IPR020635 Tyrosine-protein kinase, catalytic domain

UniProt Annotations

Entry Information

Gene Name
fibroblast growth factor receptor 1a
Protein Entry
FGR1A_DANRE
UniProt ID
Q90Z00
Species
Zebrafish

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q90Z00-1; Sequence=Displayed; Name=2; IsoId=Q90Z00-2; Sequence=VSP_037677; Name=3; IsoId=Q90Z00-3; Sequence=VSP_037675, VSP_037677; Name=4; IsoId=Q90Z00-4; Sequence=VSP_037674; Name=5; IsoId=Q90Z00-5; Sequence=VSP_037676, VSP_037677;
Catalytic Activity ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. {ECO:0000255|PROSITE- ProRule:PRU10028}.
Domain The second and third Ig-like domains directly interact with fibroblast growth factors (FGF) and heparan sulfate proteoglycans. Isoforms lacking the first Ig-like domain have higher affinity for fibroblast growth factors (FGF) and heparan sulfate proteoglycans than isoforms with all three Ig-like domains (By similarity). {ECO:0000250}.
Enzyme Regulation Present in an inactive conformation in the absence of bound ligand. Ligand binding leads to dimerization and activation by sequential autophosphorylation on tyrosine residues (By similarity). {ECO:0000250}.
Function Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol- 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by ubiquitination, internalization and degradation (By similarity). {ECO:0000250}.
Ptm Autophosphorylated. Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on tyrosine residues. Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer and proceeds in a highly ordered manner. Phosphotyrosine residues provide docking sites for interacting proteins and so are crucial for FGFR1 function and its regulation (By similarity). {ECO:0000250}.
Ptm N-glycosylated in the endoplasmic reticulum. The N-glycan chains undergo further maturation to an Endo H-resistant form in the Golgi apparatus (By similarity). {ECO:0000250}.
Ptm Ubiquitinated. FGFR1 is rapidly ubiquitinated after autophosphorylation, leading to internalization and degradation (By similarity). {ECO:0000250}.
Sequence Caution Sequence=AAI62342.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK64494.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAO45658.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAO45659.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAO45660.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily. {ECO:0000255|PROSITE-ProRule:PRU00159}.
Similarity Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
Similarity Contains 3 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.
Subcellular Location Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus (By similarity). {ECO:0000250}.
Subunit Monomer. Homodimer after ligand binding (By similarity). Interacts with cnpy1. {ECO:0000250, ECO:0000269|PubMed:16488878}.
Tissue Specificity Initially expressed in adaxial mesoderm with transcripts distinctly localized to the anterior portion of each half-somite. Hereupon, also strongly expressed in the otic vesicles, branchial arches and the brain, especially at the midbrain-hindbrain boundary (MHB). {ECO:0000269|PubMed:15221377}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011487 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
23308617 RefSeq NP_694494 806 fibroblast growth factor receptor 1-A precursor

Identical Sequences to LMP011487 proteins

Reference Database Accession Length Protein Name
GI:23308617 GenBank AAK64494.1 806 fibroblast growth factor receptor 1 isoform 1 [Danio rerio]

Related Sequences to LMP011487 proteins

Reference Database Accession Length Protein Name
GI:23308617 GenBank AAO45658.1 804 fibroblast growth factor receptor 1 isoform 2 [Danio rerio]
GI:23308617 GenBank AAO45659.1 756 fibroblast growth factor receptor 1 isoform 3 [Danio rerio]
GI:23308617 GenBank AAI62342.1 807 Fgfr1 protein [Danio rerio]
GI:23308617 GenBank ACJ66723.1 817 fibroblast growth factor receptor 1a1 [Cyprinus carpio]
GI:23308617 RefSeq XP_009302578.1 811 PREDICTED: fibroblast growth factor receptor 1-A isoform X1 [Danio rerio]
GI:23308617 RefSeq XP_009302581.1 808 PREDICTED: fibroblast growth factor receptor 1-A isoform X4 [Danio rerio]