Gene/Proteome Database (LMPD)

LMPD ID
LMP011498
Gene ID
63999
Species
Danio rerio (Zebrafish)
Gene Name
steroidogenic acute regulatory protein
Gene Symbol
star
Alternate Names
steroidogenic acute regulatory protein, mitochondrial; stARD1; START domain-containing protein 1
Chromosome
8

Proteins

steroidogenic acute regulatory protein, mitochondrial precursor
Refseq ID NP_571738
Protein GI 18859431
UniProt ID Q9DG10
mRNA ID NM_131663
Length 285
RefSeq Status PROVISIONAL
MLPATFKLCAGISYRHMRNMTGLRKNAMIAIHHELNKLSGPGASTWINHIRRRSSLLSSPIAEETYSEADQCYVQQGQEALQKSISILEDQDGWQTEIESINGEKVMSKVLPGIGKVFKLEVTLEQQTGDLYDELVDNMEQMGEWNPNVKQVKILQKIGQETMITHEISAETPGNVVGPRDFVNVRHAKRRGSTCFLAGMSTQHPGMPEQKGFVRAENGPTCIVMRPSADDPNKTKFTWLLSLDLKGWIPKTVINRVLSQTQVDFVNHLRDRMASGGGIDAAIAC

Gene Information

Entrez Gene ID
63999
Gene Name
steroidogenic acute regulatory protein
Gene Symbol
star
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IEA:UniProtKB-KW C mitochondrion
GO:0008289 IEA:UniProtKB-KW F lipid binding
GO:0008203 IEA:UniProtKB-UniPathway P cholesterol metabolic process
GO:0006869 IEA:UniProtKB-KW P lipid transport
GO:0006694 IEA:UniProtKB-KW P steroid biosynthetic process

REACTOME Pathway Links

REACTOME Pathway ID Description
6175604 Metabolism
6175643 Metabolism of lipids and lipoproteins
6176276 Metabolism of steroid hormones and vitamin D
6176278 Pregnenolone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR023393 START-like domain
IPR002913 START_lipid-bd_dom
IPR000799 Steroidogenic acute regulatory protein-like

UniProt Annotations

Entry Information

Gene Name
steroidogenic acute regulatory protein
Protein Entry
STAR_DANRE
UniProt ID
Q9DG10
Species
Zebrafish

Comments

Comment Type Description
Function Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity). {ECO:0000250}.
Pathway Steroid metabolism; cholesterol metabolism.
Similarity Contains 1 START domain. {ECO:0000255|PROSITE- ProRule:PRU00197}.
Subcellular Location Mitochondrion {ECO:0000250}.
Tissue Specificity Highly expressed in the testis and at lower levels in the ovary, kidney and head.

Identical and Related Proteins

Unique RefSeq proteins for LMP011498 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18859431 RefSeq NP_571738 285 steroidogenic acute regulatory protein, mitochondrial precursor

Identical Sequences to LMP011498 proteins

Reference Database Accession Length Protein Name
GI:18859431 GenBank AAG28593.1 285 steroidogenic acute regulatory protein [Danio rerio]
GI:18859431 GenBank AAH75967.1 285 Steroidogenic acute regulatory protein [Danio rerio]
GI:18859431 SwissProt Q9DG10.1 285 RecName: Full=Steroidogenic acute regulatory protein, mitochondrial; Short=StAR; AltName: Full=START domain-containing protein 1; Short=StARD1; Flags: Precursor [Danio rerio]

Related Sequences to LMP011498 proteins

Reference Database Accession Length Protein Name
GI:18859431 GenBank ACD37725.1 285 steroidogenic acute regulatory protein [Cyprinus carpio]
GI:18859431 GenBank ACT36705.1 285 mitochondrial sterol transfer protein [Clarias gariepinus]
GI:18859431 GenBank AEV91663.1 285 steroidogenic acute regulator protein [Gobiocypris rarus]
GI:18859431 GenBank AID69609.1 285 steroidogenic acute regulatory protein [Clarias batrachus]
GI:18859431 RefSeq NP_001187519.1 285 steroidogenic acute regulatory protein, mitochondrial [Ictalurus punctatus]
GI:18859431 RefSeq XP_007247165.1 285 PREDICTED: steroidogenic acute regulatory protein, mitochondrial [Astyanax mexicanus]